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Murcko scaffold

Ring system with 3 rings and 25 atoms

24 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
24
With full pages
6
Scaffold SMILES

O=C(c1ccccc1)N1CCN(S(=O)(=O)C=Cc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)N1CCN(S(=O)(=O)C=Cc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

1-(2-Bromo-5-methoxybenzoyl)-4-(2-phenylethenesulfonyl)piperazine chemical structure, C20H21BrN2O4S, CAS 792958-26-0
1-(2-Bromo-5-methoxybenzoyl)-4-(2-phenylethenesulfonyl)piperazine
CAS 792958-26-0C20H21BrN2O4S
1-[4-(Difluoromethoxy)-3-methoxybenzoyl]-4-(2-phenylethenesulfonyl)piperazine chemical structure, C21H22F2N2O5S, CAS 875302-40-2
1-[4-(Difluoromethoxy)-3-methoxybenzoyl]-4-(2-phenylethenesulfonyl)piperazine
CAS 875302-40-2C21H22F2N2O5S
(4-Nitrophenyl)-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]methanone chemical structure, C19H19N3O5S, CAS 931000-43-0
(4-Nitrophenyl)-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]methanone
CAS 931000-43-0C19H19N3O5S
4-[4-(2-Phenylethenesulfonyl)piperazine-1-carbonyl]benzonitrile chemical structure, C20H19N3O3S, CAS 930902-53-7
4-[4-(2-Phenylethenesulfonyl)piperazine-1-carbonyl]benzonitrile
CAS 930902-53-7C20H19N3O3S
1-(3-Fluorobenzoyl)-4-(2-phenylethenesulfonyl)piperazine chemical structure, C19H19FN2O3S, CAS 931026-25-4
1-(3-Fluorobenzoyl)-4-(2-phenylethenesulfonyl)piperazine
CAS 931026-25-4C19H19FN2O3S
1-(3-Methyl-4-nitrobenzoyl)-4-(2-phenylethenesulfonyl)piperazine chemical structure, C20H21N3O5S, CAS 931656-86-9
1-(3-Methyl-4-nitrobenzoyl)-4-(2-phenylethenesulfonyl)piperazine
CAS 931656-86-9C20H21N3O5S
1-[2-Methoxy-4-(methylsulfanyl)benzoyl]-4-(2-phenylethenesulfonyl)piperazine chemical structure, C21H24N2O4S2, CAS 852214-20-1
1-[2-Methoxy-4-(methylsulfanyl)benzoyl]-4-(2-phenylethenesulfonyl)piperazine
CAS 852214-20-1C21H24N2O4S2
1-(4,5-Dimethoxy-2-nitrobenzoyl)-4-(2-phenylethenesulfonyl)piperazine chemical structure, C21H23N3O7S, CAS 852840-95-0
1-(4,5-Dimethoxy-2-nitrobenzoyl)-4-(2-phenylethenesulfonyl)piperazine
CAS 852840-95-0C21H23N3O7S
1-[2-(Difluoromethoxy)benzoyl]-4-(2-phenylethenesulfonyl)piperazine chemical structure, C20H20F2N2O4S, CAS 849014-39-7
1-[2-(Difluoromethoxy)benzoyl]-4-(2-phenylethenesulfonyl)piperazine
CAS 849014-39-7C20H20F2N2O4S
2-({2-[4-(2-Phenylethenesulfonyl)piperazine-1-carbonyl]phenyl}sulfanyl)-N-(propan-2-yl)acetamide chemical structure, C24H29N3O4S2, CAS 865279-30-7
2-({2-[4-(2-Phenylethenesulfonyl)piperazine-1-carbonyl]phenyl}sulfanyl)-N-(propan-2-yl)acetamide
CAS 865279-30-7C24H29N3O4S2
(4-Methoxyphenyl)-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]methanone chemical structure, C20H22N2O4S, CAS 1002227-56-6
(4-Methoxyphenyl)-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]methanone
CAS 1002227-56-6C20H22N2O4S
1-(3,4-Dimethoxybenzoyl)-4-(2-phenylethenesulfonyl)piperazine chemical structure, C21H24N2O5S, CAS 949295-58-3
1-(3,4-Dimethoxybenzoyl)-4-(2-phenylethenesulfonyl)piperazine
CAS 949295-58-3C21H24N2O5S
3-[4-(2-Phenylethenesulfonyl)piperazine-1-carbonyl]benzonitrile chemical structure, C20H19N3O3S, CAS 949792-89-6
3-[4-(2-Phenylethenesulfonyl)piperazine-1-carbonyl]benzonitrile
CAS 949792-89-6C20H19N3O3S
(3-Nitrophenyl)-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]methanone chemical structure, C19H19N3O5S, CAS 879142-25-3
(3-Nitrophenyl)-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]methanone
CAS 879142-25-3C19H19N3O5S
1-(2-Phenylethenesulfonyl)-4-[4-(propan-2-yl)benzoyl]piperazine chemical structure, C22H26N2O3S, CAS 1095406-07-7
1-(2-Phenylethenesulfonyl)-4-[4-(propan-2-yl)benzoyl]piperazine
CAS 1095406-07-7C22H26N2O3S
1-(4-Chlorobenzoyl)-4-(2-phenylethenesulfonyl)piperazine chemical structure, C19H19ClN2O3S, CAS 869775-61-1
1-(4-Chlorobenzoyl)-4-(2-phenylethenesulfonyl)piperazine
CAS 869775-61-1C19H19ClN2O3S
1-(2-Phenylethenesulfonyl)-4-[2-(trifluoromethyl)benzoyl]piperazine chemical structure, C20H19F3N2O3S, CAS 930704-56-6
1-(2-Phenylethenesulfonyl)-4-[2-(trifluoromethyl)benzoyl]piperazine
CAS 930704-56-6C20H19F3N2O3S
4-Methyl-2-[4-(2-phenylethenesulfonyl)piperazine-1-carbonyl]phenol chemical structure, C20H22N2O4S, CAS 931031-43-5
4-Methyl-2-[4-(2-phenylethenesulfonyl)piperazine-1-carbonyl]phenol
CAS 931031-43-5C20H22N2O4S
1-(4-Ethylbenzoyl)-4-(2-phenylethenesulfonyl)piperazine chemical structure, C21H24N2O3S, CAS 941079-77-2
1-(4-Ethylbenzoyl)-4-(2-phenylethenesulfonyl)piperazine
CAS 941079-77-2C21H24N2O3S
2-Nitro-4-[4-(2-phenylethenesulfonyl)piperazine-1-carbonyl]aniline chemical structure, C19H20N4O5S, CAS 1088184-54-6
2-Nitro-4-[4-(2-phenylethenesulfonyl)piperazine-1-carbonyl]aniline
CAS 1088184-54-6C19H20N4O5S
1-[4-(Difluoromethoxy)benzoyl]-4-(2-phenylethenesulfonyl)piperazine chemical structure, C20H20F2N2O4S, CAS 1095360-28-3
1-[4-(Difluoromethoxy)benzoyl]-4-(2-phenylethenesulfonyl)piperazine
CAS 1095360-28-3C20H20F2N2O4S
1-(2-Bromo-4-fluorobenzoyl)-4-(2-phenylethenesulfonyl)piperazine chemical structure, C19H18BrFN2O3S, CAS 1147388-99-5
1-(2-Bromo-4-fluorobenzoyl)-4-(2-phenylethenesulfonyl)piperazine
CAS 1147388-99-5C19H18BrFN2O3S
1-[2-Chloro-5-(methylsulfanyl)benzoyl]-4-(2-phenylethenesulfonyl)piperazine chemical structure, C20H21ClN2O3S2, CAS 1181472-87-6
1-[2-Chloro-5-(methylsulfanyl)benzoyl]-4-(2-phenylethenesulfonyl)piperazine
CAS 1181472-87-6C20H21ClN2O3S2
5-Methoxy-2-[4-(2-phenylethenesulfonyl)piperazine-1-carbonyl]phenol chemical structure, C20H22N2O5S, CAS 1097535-49-3
5-Methoxy-2-[4-(2-phenylethenesulfonyl)piperazine-1-carbonyl]phenol
CAS 1097535-49-3C20H22N2O5S