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Murcko scaffold

Ring system with 3 rings and 23 atoms

72 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
72
With full pages
13
Scaffold SMILES

O=C(CN1CCN(Cc2ccccc2)CC1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN1CCN(Cc2ccccc2)CC1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 72 chemicals

2-(4-Benzylpiperazin-1-yl)-N-(4-chlorophenyl)acetamide chemical structure, C19H22ClN3O, CAS 54257-88-4
2-(4-Benzylpiperazin-1-yl)-N-(4-chlorophenyl)acetamide
CAS 54257-88-4C19H22ClN3O
2-(4-Benzylpiperazin-1-yl)-N-(5-fluoro-2-methylphenyl)acetamide chemical structure, C20H24FN3O, CAS 303091-33-0
2-(4-Benzylpiperazin-1-yl)-N-(5-fluoro-2-methylphenyl)acetamide
CAS 303091-33-0C20H24FN3O
2-(4-Benzylpiperazin-1-yl)-N-(2-cyanophenyl)acetamide chemical structure, C20H22N4O, CAS 303091-39-6
2-(4-Benzylpiperazin-1-yl)-N-(2-cyanophenyl)acetamide
CAS 303091-39-6C20H22N4O
2-(4-Benzylpiperazin-1-yl)-N-(4-bromophenyl)acetamide chemical structure, C19H22BrN3O, CAS 303091-48-7
2-(4-Benzylpiperazin-1-yl)-N-(4-bromophenyl)acetamide
CAS 303091-48-7C19H22BrN3O
2-(4-Benzylpiperazin-1-yl)-N-[4-(trifluoromethoxy)phenyl]acetamide chemical structure, C20H22F3N3O2, CAS 442672-22-2
2-(4-Benzylpiperazin-1-yl)-N-[4-(trifluoromethoxy)phenyl]acetamide
CAS 442672-22-2C20H22F3N3O2
2-(4-Benzylpiperazin-1-yl)-N-(3,4-dichlorophenyl)acetamide chemical structure, C19H21Cl2N3O, CAS 54257-87-3
2-(4-Benzylpiperazin-1-yl)-N-(3,4-dichlorophenyl)acetamide
CAS 54257-87-3C19H21Cl2N3O
2-(4-Benzyl-1-piperazinyl)-N-(3-chloro-4-methylphenyl)acetamide chemical structure, C20H24ClN3O, CAS 332908-98-2
2-(4-Benzyl-1-piperazinyl)-N-(3-chloro-4-methylphenyl)acetamide
CAS 332908-98-2C20H24ClN3O
Methyl 2-{2-[4-benzylpiperazinyl]acetylamino}benzoate chemical structure, C21H25N3O3, CAS 304861-75-4
Methyl 2-{2-[4-benzylpiperazinyl]acetylamino}benzoate
CAS 304861-75-4C21H25N3O3
2-(4-Benzylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide chemical structure, C19H24N4O3S, CAS 694466-00-7
2-(4-Benzylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide
CAS 694466-00-7C19H24N4O3S
2-(4-Benzylpiperazin-1-yl)-N-(3-cyanophenyl)acetamide chemical structure, C20H22N4O, CAS 731829-18-8
2-(4-Benzylpiperazin-1-yl)-N-(3-cyanophenyl)acetamide
CAS 731829-18-8C20H22N4O
2-(4-Benzylpiperazin-1-yl)-N-(2,4-difluorophenyl)acetamide chemical structure, C19H21F2N3O, CAS 889602-88-4
2-(4-Benzylpiperazin-1-yl)-N-(2,4-difluorophenyl)acetamide
CAS 889602-88-4C19H21F2N3O
2-(4-Benzylpiperazin-1-yl)-N-(4-methoxyphenyl)acetamide chemical structure, C20H25N3O2, CAS 406929-45-1
2-(4-Benzylpiperazin-1-yl)-N-(4-methoxyphenyl)acetamide
CAS 406929-45-1C20H25N3O2
2-(4-Benzylpiperazin-1-yl)-N-(4-butylphenyl)acetamide chemical structure, C23H31N3O, CAS 303091-32-9
2-(4-Benzylpiperazin-1-yl)-N-(4-butylphenyl)acetamide
CAS 303091-32-9C23H31N3O
2-(4-Benzylpiperazin-1-yl)-N-(4-chloro-2,5-dimethoxyphenyl)acetamide chemical structure, C21H26ClN3O3, CAS 868256-34-2
2-(4-Benzylpiperazin-1-yl)-N-(4-chloro-2,5-dimethoxyphenyl)acetamide
CAS 868256-34-2C21H26ClN3O3
2-(4-Benzylpiperazin-1-yl)-N-(2-ethoxyphenyl)acetamide chemical structure, C21H27N3O2, CAS 647031-45-6
2-(4-Benzylpiperazin-1-yl)-N-(2-ethoxyphenyl)acetamide
CAS 647031-45-6C21H27N3O2
2-{[2-(4-Benzylpiperazino)acetyl]amino}benzenecarboxamide chemical structure, C20H24N4O2, CAS 774137-08-5
2-{[2-(4-Benzylpiperazino)acetyl]amino}benzenecarboxamide
CAS 774137-08-5C20H24N4O2
2-(4-Benzylpiperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide chemical structure, C21H27N3O, CAS 55340-20-0
2-(4-Benzylpiperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide
CAS 55340-20-0C21H27N3O
N-(2-Fluorophenyl)-2-[4-[(3-fluorophenyl)methyl]piperazin-1-yl]acetamide chemical structure, C19H21F2N3O, CAS 697769-09-8
N-(2-Fluorophenyl)-2-[4-[(3-fluorophenyl)methyl]piperazin-1-yl]acetamide
CAS 697769-09-8C19H21F2N3O
2-{4-[(2,6-Difluorophenyl)methyl]piperazin-1-YL}-N-(2-fluorophenyl)acetamide chemical structure, C19H20F3N3O, CAS 899713-87-2
2-{4-[(2,6-Difluorophenyl)methyl]piperazin-1-YL}-N-(2-fluorophenyl)acetamide
CAS 899713-87-2C19H20F3N3O
2-(4-Benzylpiperazin-1-yl)-N-(4-chloro-2-methylphenyl)acetamide chemical structure, C20H24ClN3O, CAS 879859-16-2
2-(4-Benzylpiperazin-1-yl)-N-(4-chloro-2-methylphenyl)acetamide
CAS 879859-16-2C20H24ClN3O
2-[[2-[4-[(3-Methoxyphenyl)methyl]piperazin-1-yl]acetyl]amino]benzamide chemical structure, C21H26N4O3, CAS 890578-66-2
2-[[2-[4-[(3-Methoxyphenyl)methyl]piperazin-1-yl]acetyl]amino]benzamide
CAS 890578-66-2C21H26N4O3
2-[4-[(3-Chlorophenyl)methyl]piperazin-1-yl]-N-(2,4-difluorophenyl)acetamide chemical structure, C19H20ClF2N3O, CAS 891741-76-7
2-[4-[(3-Chlorophenyl)methyl]piperazin-1-yl]-N-(2,4-difluorophenyl)acetamide
CAS 891741-76-7C19H20ClF2N3O
N-(2,5-Dimethylphenyl)-2-[4-[(3-methoxyphenyl)methyl]piperazin-1-yl]acetamide chemical structure, C22H29N3O2, CAS 894317-33-0
N-(2,5-Dimethylphenyl)-2-[4-[(3-methoxyphenyl)methyl]piperazin-1-yl]acetamide
CAS 894317-33-0C22H29N3O2
N-(2,5-Dimethoxyphenyl)-2-[4-[(4-methylphenyl)methyl]piperazin-1-yl]acetamide chemical structure, C22H29N3O3, CAS 904468-74-2
N-(2,5-Dimethoxyphenyl)-2-[4-[(4-methylphenyl)methyl]piperazin-1-yl]acetamide
CAS 904468-74-2C22H29N3O3