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Murcko scaffold

Ring system with 3 rings and 25 atoms

29 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
29
With full pages
7
Scaffold SMILES

O=C(NCc1ccccc1)C1CCN(S(=O)(=O)c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCc1ccccc1)C1CCN(S(=O)(=O)c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

N-[(2,4-Dichlorophenyl)methyl]-1-(2,5-dimethoxyphenyl)sulfonylpiperidine-4-carboxamide chemical structure, C21H24Cl2N2O5S, CAS 701926-20-7
N-[(2,4-Dichlorophenyl)methyl]-1-(2,5-dimethoxyphenyl)sulfonylpiperidine-4-carboxamide
CAS 701926-20-7C21H24Cl2N2O5S
Antimalarial agent 17 chemical structure, C19H21ClN2O3S, CAS 508187-76-6
Antimalarial agent 17
CAS 508187-76-6C19H21ClN2O3S
N-[(2-Chlorophenyl)methyl]-1-(4-methylphenyl)sulfonyl-4-piperidinecarboxamide chemical structure, C20H23ClN2O3S, CAS 551931-43-2
N-[(2-Chlorophenyl)methyl]-1-(4-methylphenyl)sulfonyl-4-piperidinecarboxamide
CAS 551931-43-2C20H23ClN2O3S
N-[(4-Methoxyphenyl)methyl]-1-(4-methylphenyl)sulfonylpiperidine-4-carboxamide chemical structure, C21H26N2O4S, CAS 433705-07-8
N-[(4-Methoxyphenyl)methyl]-1-(4-methylphenyl)sulfonylpiperidine-4-carboxamide
CAS 433705-07-8C21H26N2O4S
N-Benzyl-1-(4-methylphenyl)sulfonylpiperidine-4-carboxamide chemical structure, C20H24N2O3S, CAS 433944-21-9
N-Benzyl-1-(4-methylphenyl)sulfonylpiperidine-4-carboxamide
CAS 433944-21-9C20H24N2O3S
1-(Benzenesulfonyl)-N-[(4-methylphenyl)methyl]piperidine-4-carboxamide chemical structure, C20H24N2O3S, CAS 591239-56-4
1-(Benzenesulfonyl)-N-[(4-methylphenyl)methyl]piperidine-4-carboxamide
CAS 591239-56-4C20H24N2O3S
N-(4-Chlorobenzyl)-1-[(4-chlorophenyl)sulfonyl]piperidine-4-carboxamide chemical structure, C19H20Cl2N2O3S, CAS 433964-97-7
N-(4-Chlorobenzyl)-1-[(4-chlorophenyl)sulfonyl]piperidine-4-carboxamide
CAS 433964-97-7C19H20Cl2N2O3S
1-(Benzenesulfonyl)-N-[(4-chlorophenyl)methyl]piperidine-4-carboxamide chemical structure, C19H21ClN2O3S, CAS 511239-17-1
1-(Benzenesulfonyl)-N-[(4-chlorophenyl)methyl]piperidine-4-carboxamide
CAS 511239-17-1C19H21ClN2O3S
N-(2-Chlorobenzyl)-1-((4-fluorophenyl)sulfonyl)piperidine-4-carboxamide chemical structure, C19H20ClFN2O3S, CAS 508187-98-2
N-(2-Chlorobenzyl)-1-((4-fluorophenyl)sulfonyl)piperidine-4-carboxamide
CAS 508187-98-2C19H20ClFN2O3S
N-Benzyl-1-(4-bromophenyl)sulfonyl-N-methylpiperidine-4-carboxamide chemical structure, C20H23BrN2O3S, CAS 433944-25-3
N-Benzyl-1-(4-bromophenyl)sulfonyl-N-methylpiperidine-4-carboxamide
CAS 433944-25-3C20H23BrN2O3S
N-(4-Methoxybenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide chemical structure, C23H30N2O4S, CAS 700855-96-5
N-(4-Methoxybenzyl)-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide
CAS 700855-96-5C23H30N2O4S
N-(2,4-Dichlorobenzyl)-1-[(4-methylphenyl)sulfonyl]piperidine-4-carboxamide chemical structure, C20H22Cl2N2O3S, CAS 593261-71-3
N-(2,4-Dichlorobenzyl)-1-[(4-methylphenyl)sulfonyl]piperidine-4-carboxamide
CAS 593261-71-3C20H22Cl2N2O3S
N-(2,4-Dichlorobenzyl)-1-(mesitylsulfonyl)-4-piperidinecarboxamide chemical structure, C22H26Cl2N2O3S, CAS 639500-61-1
N-(2,4-Dichlorobenzyl)-1-(mesitylsulfonyl)-4-piperidinecarboxamide
CAS 639500-61-1C22H26Cl2N2O3S
N-Benzyl-1-(4-fluorophenyl)sulfonyl-N-methylpiperidine-4-carboxamide chemical structure, C20H23FN2O3S, CAS 591227-02-0
N-Benzyl-1-(4-fluorophenyl)sulfonyl-N-methylpiperidine-4-carboxamide
CAS 591227-02-0C20H23FN2O3S
1-[(4-Fluorophenyl)sulfonyl]-N-(4-methylbenzyl)piperidine-4-carboxamide chemical structure, C20H23FN2O3S, CAS 508187-48-2
1-[(4-Fluorophenyl)sulfonyl]-N-(4-methylbenzyl)piperidine-4-carboxamide
CAS 508187-48-2C20H23FN2O3S
N-[(4-Chlorophenyl)methyl]-1-(4-fluorophenyl)sulfonylpiperidine-4-carboxamide chemical structure, C19H20ClFN2O3S, CAS 591239-54-2
N-[(4-Chlorophenyl)methyl]-1-(4-fluorophenyl)sulfonylpiperidine-4-carboxamide
CAS 591239-54-2C19H20ClFN2O3S
1-(4-Fluorophenyl)sulfonyl-N-[(4-methoxyphenyl)methyl]piperidine-4-carboxamide chemical structure, C20H23FN2O4S, CAS 591238-85-6
1-(4-Fluorophenyl)sulfonyl-N-[(4-methoxyphenyl)methyl]piperidine-4-carboxamide
CAS 591238-85-6C20H23FN2O4S
N-[(2-Chlorophenyl)methyl]-1-(4-chlorophenyl)sulfonylpiperidine-4-carboxamide chemical structure, C19H20Cl2N2O3S, CAS 510766-58-2
N-[(2-Chlorophenyl)methyl]-1-(4-chlorophenyl)sulfonylpiperidine-4-carboxamide
CAS 510766-58-2C19H20Cl2N2O3S
1-(4-Bromophenyl)sulfonyl-N-(1-phenylethyl)piperidine-4-carboxamide chemical structure, C20H23BrN2O3S, CAS 433706-86-6
1-(4-Bromophenyl)sulfonyl-N-(1-phenylethyl)piperidine-4-carboxamide
CAS 433706-86-6C20H23BrN2O3S
1-(4-Methylphenyl)sulfonyl-N-(1-phenylethyl)piperidine-4-carboxamide chemical structure, C21H26N2O3S, CAS 433707-54-1
1-(4-Methylphenyl)sulfonyl-N-(1-phenylethyl)piperidine-4-carboxamide
CAS 433707-54-1C21H26N2O3S
1-(3,4-Dimethoxyphenyl)sulfonyl-N-(1-phenylethyl)piperidine-4-carboxamide chemical structure, C22H28N2O5S, CAS 591238-23-2
1-(3,4-Dimethoxyphenyl)sulfonyl-N-(1-phenylethyl)piperidine-4-carboxamide
CAS 591238-23-2C22H28N2O5S
N-[(2,4-Dichlorophenyl)methyl]-1-(4-fluorophenyl)sulfonylpiperidine-4-carboxamide chemical structure, C19H19Cl2FN2O3S, CAS 593261-74-6
N-[(2,4-Dichlorophenyl)methyl]-1-(4-fluorophenyl)sulfonylpiperidine-4-carboxamide
CAS 593261-74-6C19H19Cl2FN2O3S
N-Benzyl-1-[(5-fluoro-2-methoxyphenyl)sulfonyl]piperidine-4-carboxamide chemical structure, C20H23FN2O4S, CAS 942890-45-1
N-Benzyl-1-[(5-fluoro-2-methoxyphenyl)sulfonyl]piperidine-4-carboxamide
CAS 942890-45-1C20H23FN2O4S
N-[(2-Methoxyphenyl)methyl]-1-[[4-(methylamino)-3-nitrophenyl]sulfonyl]-4-piperidinecarboxamide chemical structure, C21H26N4O6S, CAS 941117-69-7
N-[(2-Methoxyphenyl)methyl]-1-[[4-(methylamino)-3-nitrophenyl]sulfonyl]-4-piperidinecarboxamide
CAS 941117-69-7C21H26N4O6S