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Murcko scaffold

Ring system with 3 rings and 24 atoms

44 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
44
With full pages
15
Scaffold SMILES

O=C(COc1ccccc1)N1CCN(C(=O)c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COc1ccccc1)N1CCN(C(=O)c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 44 of 44 chemicals

Piperazine, 1-(4-fluorobenzoyl)-4-(4-chlorophenoxyacetyl)- chemical structure, C19H18ClFN2O3, CAS 333756-76-6
Piperazine, 1-(4-fluorobenzoyl)-4-(4-chlorophenoxyacetyl)-
CAS 333756-76-6C19H18ClFN2O3
1-[4-(2-Methoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone chemical structure, C21H24N2O4, CAS 423742-76-1
1-[4-(2-Methoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone
CAS 423742-76-1C21H24N2O4
1-(4-Benzoylpiperazin-1-yl)-2-(3-methylphenoxy)ethanone chemical structure, C20H22N2O3, CAS 423738-99-2
1-(4-Benzoylpiperazin-1-yl)-2-(3-methylphenoxy)ethanone
CAS 423738-99-2C20H22N2O3
1-[4-(4-Fluorobenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone chemical structure, C20H21FN2O3, CAS 423754-17-0
1-[4-(4-Fluorobenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone
CAS 423754-17-0C20H21FN2O3
1-[4-(2,3-Dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone chemical structure, C22H26N2O5, CAS 423748-02-1
1-[4-(2,3-Dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone
CAS 423748-02-1C22H26N2O5
1-[4-(3-Methoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone chemical structure, C21H24N2O4, CAS 423751-84-2
1-[4-(3-Methoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone
CAS 423751-84-2C21H24N2O4
1-[4-(2-Fluorobenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone chemical structure, C20H21FN2O3, CAS 423750-33-8
1-[4-(2-Fluorobenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone
CAS 423750-33-8C20H21FN2O3
1-[4-(3-Fluorobenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone chemical structure, C20H21FN2O3, CAS 423738-34-5
1-[4-(3-Fluorobenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone
CAS 423738-34-5C20H21FN2O3
1-[4-(4-Methoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone chemical structure, C21H24N2O4, CAS 423737-53-5
1-[4-(4-Methoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone
CAS 423737-53-5C21H24N2O4
2-(3-Methylphenoxy)-1-[4-(4-nitrobenzoyl)piperazin-1-yl]ethanone chemical structure, C20H21N3O5, CAS 423732-51-8
2-(3-Methylphenoxy)-1-[4-(4-nitrobenzoyl)piperazin-1-yl]ethanone
CAS 423732-51-8C20H21N3O5
1-[4-(3,4-Dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone chemical structure, C22H26N2O5, CAS 423734-55-8
1-[4-(3,4-Dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone
CAS 423734-55-8C22H26N2O5
2-(4-Chlorophenoxy)-1-[4-(2,3-dimethoxybenzoyl)piperazin-1-yl]ethanone chemical structure, C21H23ClN2O5, CAS 510713-96-9
2-(4-Chlorophenoxy)-1-[4-(2,3-dimethoxybenzoyl)piperazin-1-yl]ethanone
CAS 510713-96-9C21H23ClN2O5
2-(4-Chlorophenoxy)-1-[4-(4-methoxybenzoyl)piperazin-1-yl]ethanone chemical structure, C20H21ClN2O4, CAS 522650-46-0
2-(4-Chlorophenoxy)-1-[4-(4-methoxybenzoyl)piperazin-1-yl]ethanone
CAS 522650-46-0C20H21ClN2O4
1-(2-Methoxybenzoyl)-4-(phenoxyacetyl)piperazine chemical structure, C20H22N2O4, CAS 488744-34-9
1-(2-Methoxybenzoyl)-4-(phenoxyacetyl)piperazine
CAS 488744-34-9C20H22N2O4
1-[4-(3,4-Dimethoxybenzoyl)piperazin-1-yl]-2-(4-methylphenoxy)ethanone chemical structure, C22H26N2O5, CAS 488088-62-6
1-[4-(3,4-Dimethoxybenzoyl)piperazin-1-yl]-2-(4-methylphenoxy)ethanone
CAS 488088-62-6C22H26N2O5
2-(4-Methylphenoxy)-1-[4-(4-nitrobenzoyl)piperazin-1-yl]ethanone chemical structure, C20H21N3O5, CAS 522650-54-0
2-(4-Methylphenoxy)-1-[4-(4-nitrobenzoyl)piperazin-1-yl]ethanone
CAS 522650-54-0C20H21N3O5
2-(4-Chlorophenoxy)-1-[4-(2-fluorobenzoyl)piperazin-1-yl]ethanone chemical structure, C19H18ClFN2O3, CAS 510718-38-4
2-(4-Chlorophenoxy)-1-[4-(2-fluorobenzoyl)piperazin-1-yl]ethanone
CAS 510718-38-4C19H18ClFN2O3
2-(4-Chloro-phenoxy)-1-[4-(3,4,5-trimethoxy-benzoyl)-piperazin-1-yl]-ethanone chemical structure, C22H25ClN2O6, CAS 333756-14-2
2-(4-Chloro-phenoxy)-1-[4-(3,4,5-trimethoxy-benzoyl)-piperazin-1-yl]-ethanone
CAS 333756-14-2C22H25ClN2O6
2-(4-Chloro-phenoxy)-1-[4-(2-methoxy-benzoyl)-piperazin-1-yl]-ethanone chemical structure, C20H21ClN2O4, CAS 333756-37-9
2-(4-Chloro-phenoxy)-1-[4-(2-methoxy-benzoyl)-piperazin-1-yl]-ethanone
CAS 333756-37-9C20H21ClN2O4
1-[(4-Chlorophenoxy)acetyl]-4-(3-fluorobenzoyl)piperazine chemical structure, C19H18ClFN2O3, CAS 441743-14-2
1-[(4-Chlorophenoxy)acetyl]-4-(3-fluorobenzoyl)piperazine
CAS 441743-14-2C19H18ClFN2O3
1-[(4-Chlorophenoxy)acetyl]-4-(3,5-dimethoxybenzoyl)piperazine chemical structure, C21H23ClN2O5, CAS 333757-14-5
1-[(4-Chlorophenoxy)acetyl]-4-(3,5-dimethoxybenzoyl)piperazine
CAS 333757-14-5C21H23ClN2O5
1-{4-[(4-Nitrophenyl)carbonyl]piperazin-1-yl}-2-phenoxyethanone chemical structure, C19H19N3O5, CAS 423738-16-3
1-{4-[(4-Nitrophenyl)carbonyl]piperazin-1-yl}-2-phenoxyethanone
CAS 423738-16-3C19H19N3O5
1-[4-(3-Chlorobenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone chemical structure, C20H21ClN2O3, CAS 423745-31-7
1-[4-(3-Chlorobenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone
CAS 423745-31-7C20H21ClN2O3
1-[4-(4-Fluorobenzoyl)piperazin-1-yl]-2-(4-methoxyphenoxy)ethanone chemical structure, C20H21FN2O4, CAS 423746-15-0
1-[4-(4-Fluorobenzoyl)piperazin-1-yl]-2-(4-methoxyphenoxy)ethanone
CAS 423746-15-0C20H21FN2O4