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Murcko scaffold

2-[4-(Benzenesulfonyl)piperazin-1-yl]-N-phenylacetamide scaffold

63 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
63
With full pages
8
Scaffold SMILES

O=C(CN1CCN(S(=O)(=O)c2ccccc2)CC1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-[4-(Benzenesulfonyl)piperazin-1-yl]-N-phenylacetamide page
Murcko scaffold O=C(CN1CCN(S(=O)(=O)c2ccccc2)CC1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 63 chemicals

2-{4-[(4-Chlorophenyl)sulfonyl]-1-piperazinyl}-N-(4-methoxyphenyl)acetamide chemical structure, C19H22ClN3O4S, CAS 708240-90-8
2-{4-[(4-Chlorophenyl)sulfonyl]-1-piperazinyl}-N-(4-methoxyphenyl)acetamide
CAS 708240-90-8C19H22ClN3O4S
2-[4-(Benzenesulfonyl)piperazin-1-yl]-N-(4-methoxyphenyl)acetamide chemical structure, C19H23N3O4S, CAS 700858-57-7
2-[4-(Benzenesulfonyl)piperazin-1-yl]-N-(4-methoxyphenyl)acetamide
CAS 700858-57-7C19H23N3O4S
2-[4-(4-Fluorobenzenesulfonyl)piperazin-1-yl]-N-(4-methoxyphenyl)acetamide chemical structure, C19H22FN3O4S, CAS 712345-11-4
2-[4-(4-Fluorobenzenesulfonyl)piperazin-1-yl]-N-(4-methoxyphenyl)acetamide
CAS 712345-11-4C19H22FN3O4S
2-{4-[(2,4-Dimethylphenyl)sulfonyl]piperazinyl}-N-(4-bromophenyl)acetamide chemical structure, C20H24BrN3O3S, CAS 691398-60-4
2-{4-[(2,4-Dimethylphenyl)sulfonyl]piperazinyl}-N-(4-bromophenyl)acetamide
CAS 691398-60-4C20H24BrN3O3S
2-[4-(Benzenesulfonyl)piperazin-1-yl]-N-(4-bromophenyl)acetamide chemical structure, C18H20BrN3O3S, CAS 691398-68-2
2-[4-(Benzenesulfonyl)piperazin-1-yl]-N-(4-bromophenyl)acetamide
CAS 691398-68-2C18H20BrN3O3S
2-[4-(Benzenesulfonyl)piperazin-1-yl]-N-(2,5-dichlorophenyl)acetamide chemical structure, C18H19Cl2N3O3S, CAS 700855-87-4
2-[4-(Benzenesulfonyl)piperazin-1-yl]-N-(2,5-dichlorophenyl)acetamide
CAS 700855-87-4C18H19Cl2N3O3S
N-(2,5-Dichlorophenyl)-2-{4-[(2,4-dimethylphenyl)sulfonyl]piperazinyl}acetamid e chemical structure, C20H23Cl2N3O3S, CAS 700853-55-0
N-(2,5-Dichlorophenyl)-2-{4-[(2,4-dimethylphenyl)sulfonyl]piperazinyl}acetamid e
CAS 700853-55-0C20H23Cl2N3O3S
2-{4-[(4-Chlorophenyl)sulfonyl]piperazinyl}-N-(4-fluorophenyl)acetamide chemical structure, C18H19ClFN3O3S, CAS 701276-83-7
2-{4-[(4-Chlorophenyl)sulfonyl]piperazinyl}-N-(4-fluorophenyl)acetamide
CAS 701276-83-7C18H19ClFN3O3S
N-(2,5-Dichlorophenyl)-2-[4-(2,4,6-trimethylbenzenesulfonyl)piperazin-1-yl]acetamide chemical structure, C21H25Cl2N3O3S, CAS 706768-49-2
N-(2,5-Dichlorophenyl)-2-[4-(2,4,6-trimethylbenzenesulfonyl)piperazin-1-yl]acetamide
CAS 706768-49-2C21H25Cl2N3O3S
2-[4-(2,4-Dimethylphenyl)sulfonylpiperazin-1-yl]-N-(4-fluorophenyl)acetamide chemical structure, C20H24FN3O3S, CAS 706774-63-2
2-[4-(2,4-Dimethylphenyl)sulfonylpiperazin-1-yl]-N-(4-fluorophenyl)acetamide
CAS 706774-63-2C20H24FN3O3S
N-(4-Fluorophenyl)-2-[4-(4-fluorophenyl)sulfonylpiperazin-1-yl]acetamide chemical structure, C18H19F2N3O3S, CAS 712345-09-0
N-(4-Fluorophenyl)-2-[4-(4-fluorophenyl)sulfonylpiperazin-1-yl]acetamide
CAS 712345-09-0C18H19F2N3O3S
N-(4-Bromophenyl)-2-{4-[(4-fluorophenyl)sulfonyl]piperazinyl}acetamide chemical structure, C18H19BrFN3O3S, CAS 712345-10-3
N-(4-Bromophenyl)-2-{4-[(4-fluorophenyl)sulfonyl]piperazinyl}acetamide
CAS 712345-10-3C18H19BrFN3O3S
N-(2,5-Dichlorophenyl)-2-[4-(4-fluorobenzenesulfonyl)piperazin-1-yl]acetamide chemical structure, C18H18Cl2FN3O3S, CAS 712345-12-5
N-(2,5-Dichlorophenyl)-2-[4-(4-fluorobenzenesulfonyl)piperazin-1-yl]acetamide
CAS 712345-12-5C18H18Cl2FN3O3S
N-(4-Methoxyphenyl)-2-[4-(2,4,6-trimethylphenyl)sulfonylpiperazin-1-yl]acetamide chemical structure, C22H29N3O4S, CAS 708238-12-4
N-(4-Methoxyphenyl)-2-[4-(2,4,6-trimethylphenyl)sulfonylpiperazin-1-yl]acetamide
CAS 708238-12-4C22H29N3O4S
N-(4-Bromophenyl)-2-[4-(2,4,6-trimethylbenzenesulfonyl)piperazin-1-yl]acetamide chemical structure, C21H26BrN3O3S, CAS 701971-95-1
N-(4-Bromophenyl)-2-[4-(2,4,6-trimethylbenzenesulfonyl)piperazin-1-yl]acetamide
CAS 701971-95-1C21H26BrN3O3S
N-(5-Chloro-2-methylphenyl)-2-(4-tosylpiperazin-1-yl)acetamide chemical structure, C20H24ClN3O3S, CAS 832728-37-7
N-(5-Chloro-2-methylphenyl)-2-(4-tosylpiperazin-1-yl)acetamide
CAS 832728-37-7C20H24ClN3O3S
2-[4-(Benzenesulfonyl)piperazin-1-yl]-N-(2,6-dichlorophenyl)acetamide chemical structure, C18H19Cl2N3O3S, CAS 832729-11-0
2-[4-(Benzenesulfonyl)piperazin-1-yl]-N-(2,6-dichlorophenyl)acetamide
CAS 832729-11-0C18H19Cl2N3O3S
2-[4-(Benzenesulfonyl)piperazin-1-yl]-N-(5-chloro-2-methylphenyl)acetamide chemical structure, C19H22ClN3O3S, CAS 832147-46-3
2-[4-(Benzenesulfonyl)piperazin-1-yl]-N-(5-chloro-2-methylphenyl)acetamide
CAS 832147-46-3C19H22ClN3O3S
N-(4-Fluorophenyl)-2-[4-(4-methylphenyl)sulfonylpiperazin-1-yl]acetamide chemical structure, C19H22FN3O3S, CAS 701926-99-0
N-(4-Fluorophenyl)-2-[4-(4-methylphenyl)sulfonylpiperazin-1-yl]acetamide
CAS 701926-99-0C19H22FN3O3S
N-(4-Bromophenyl)-2-{4-[(4-chlorophenyl)sulfonyl]piperazinyl}acetamide chemical structure, C18H19BrClN3O3S, CAS 89474-66-8
N-(4-Bromophenyl)-2-{4-[(4-chlorophenyl)sulfonyl]piperazinyl}acetamide
CAS 89474-66-8C18H19BrClN3O3S
2-[4-(4-Chlorophenyl)sulfonylpiperazin-1-yl]-N-(2-fluorophenyl)acetamide chemical structure, C18H19ClFN3O3S, CAS 890275-91-9
2-[4-(4-Chlorophenyl)sulfonylpiperazin-1-yl]-N-(2-fluorophenyl)acetamide
CAS 890275-91-9C18H19ClFN3O3S
2-[4-(4-Chlorophenyl)sulfonylpiperazin-1-yl]-N-(2-methoxyphenyl)acetamide chemical structure, C19H22ClN3O4S, CAS 851469-17-5
2-[4-(4-Chlorophenyl)sulfonylpiperazin-1-yl]-N-(2-methoxyphenyl)acetamide
CAS 851469-17-5C19H22ClN3O4S
N-(4-Bromophenyl)-2-{4-[(4-methylphenyl)sulfonyl]piperazinyl}acetamide chemical structure, C19H22BrN3O3S, CAS 89474-67-9
N-(4-Bromophenyl)-2-{4-[(4-methylphenyl)sulfonyl]piperazinyl}acetamide
CAS 89474-67-9C19H22BrN3O3S
2-[4-(Benzenesulfonyl)piperazin-1-yl]-N-(2-chlorophenyl)acetamide chemical structure, C18H20ClN3O3S, CAS 890268-84-5
2-[4-(Benzenesulfonyl)piperazin-1-yl]-N-(2-chlorophenyl)acetamide
CAS 890268-84-5C18H20ClN3O3S