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Murcko scaffold

1,4-Dioxa-7-azaspiro(4.5)decane scaffold

26 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
26
With full pages
3
Scaffold SMILES

C1CNCC2(C1)OCCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,4-Dioxa-7-azaspiro(4.5)decane page
Murcko scaffold C1CNCC2(C1)OCCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

Methyl 10-((hydroxyamino)carbonyl)-1,4-dioxa-7-azaspiro(4.5)decane-7-carboxylate chemical structure, C10H16N2O6, CAS 65202-61-1
Methyl 10-((hydroxyamino)carbonyl)-1,4-dioxa-7-azaspiro(4.5)decane-7-carboxylate
CAS 65202-61-1C10H16N2O6
10-Ethyl 7-methyl 1,4-dioxa-7-azaspiro(4.5)decane-7,10-dicarboxylate chemical structure, C12H19NO6, CAS 65202-60-0
10-Ethyl 7-methyl 1,4-dioxa-7-azaspiro(4.5)decane-7,10-dicarboxylate
CAS 65202-60-0C12H19NO6
1,4-Dioxa-7-azaspiro(4.5)decane chemical structure, C7H13NO2, CAS 40369-91-3
1,4-Dioxa-7-azaspiro(4.5)decane
CAS 40369-91-3C7H13NO2
Ethyl 10-[(hydroxyamino)carbonyl]-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate chemical structure, C11H18N2O6, CAS 85118-31-6
Ethyl 10-[(hydroxyamino)carbonyl]-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate
CAS 85118-31-6C11H18N2O6
Diethyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate chemical structure, C13H21NO6, CAS 85118-35-0
Diethyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate
CAS 85118-35-0C13H21NO6
(8S)-1,4-Dioxa-9-azaspiro[4.5]decane-8-carboxylic acid chemical structure, C8H13NO4, CAS 1234692-61-5
(8S)-1,4-Dioxa-9-azaspiro[4.5]decane-8-carboxylic acid
CAS 1234692-61-5C8H13NO4
N-Allyl-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxamide chemical structure, C11H18N2O3, CAS 1424076-76-5
N-Allyl-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxamide
CAS 1424076-76-5C11H18N2O3
1,4-Dioxa-9-azaspiro[4.5]decane-8-carboxylic acid chemical structure, C8H13NO4, CAS 1822537-35-8
1,4-Dioxa-9-azaspiro[4.5]decane-8-carboxylic acid
CAS 1822537-35-8C8H13NO4
tert-Butyl 1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate chemical structure, C12H21NO4, CAS 1499963-20-0
tert-Butyl 1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate
CAS 1499963-20-0C12H21NO4
2-Hydroxyethyl 1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate chemical structure, C10H17NO5, CAS 1537549-37-3
2-Hydroxyethyl 1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate
CAS 1537549-37-3C10H17NO5
Ethyl 1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate chemical structure, C10H17NO4, CAS 1538357-22-0
Ethyl 1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate
CAS 1538357-22-0C10H17NO4
7-(But-3-yn-1-yl)-1,4-dioxa-7-azaspiro[4.5]decane chemical structure, C11H17NO2, CAS 1518654-15-3
7-(But-3-yn-1-yl)-1,4-dioxa-7-azaspiro[4.5]decane
CAS 1518654-15-3C11H17NO2
Propan-2-yl 1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate chemical structure, C11H19NO4, CAS 1511235-77-0
Propan-2-yl 1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate
CAS 1511235-77-0C11H19NO4
2-Methylpropyl 1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate chemical structure, C12H21NO4, CAS 1540644-02-7
2-Methylpropyl 1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate
CAS 1540644-02-7C12H21NO4
2-Chloro-1-{1,4-dioxa-7-azaspiro[4.5]decan-7-yl}propan-1-one chemical structure, C10H16ClNO3, CAS 1517020-09-5
2-Chloro-1-{1,4-dioxa-7-azaspiro[4.5]decan-7-yl}propan-1-one
CAS 1517020-09-5C10H16ClNO3
1-{1,4-Dioxa-7-azaspiro[4.5]decan-7-yl}-3-fluoropropan-2-ol chemical structure, C10H18FNO3, CAS 1859154-95-2
1-{1,4-Dioxa-7-azaspiro[4.5]decan-7-yl}-3-fluoropropan-2-ol
CAS 1859154-95-2C10H18FNO3
tert-Butyl 2-(chloromethyl)-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate chemical structure, C13H22ClNO4, CAS 2171975-79-2
tert-Butyl 2-(chloromethyl)-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate
CAS 2171975-79-2C13H22ClNO4
tert-Butyl 2-(bromomethyl)-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate chemical structure, C13H22BrNO4, CAS 2172249-07-7
tert-Butyl 2-(bromomethyl)-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate
CAS 2172249-07-7C13H22BrNO4
1,4-Dioxa-7-azaspiro[4.5]decane-7-carbonyl chloride chemical structure, C8H12ClNO3, CAS 2172565-47-6
1,4-Dioxa-7-azaspiro[4.5]decane-7-carbonyl chloride
CAS 2172565-47-6C8H12ClNO3
tert-Butyl 2-(hydroxymethyl)-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate chemical structure, C13H23NO5, CAS 2172158-12-0
tert-Butyl 2-(hydroxymethyl)-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate
CAS 2172158-12-0C13H23NO5
tert-Butyl 2-(aminomethyl)-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate chemical structure, C13H24N2O4, CAS 2171910-86-2
tert-Butyl 2-(aminomethyl)-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate
CAS 2171910-86-2C13H24N2O4
3-{1,4-Dioxa-7-azaspiro[4.5]decan-7-yl}-2,2-difluoropropanoic acid chemical structure, C10H15F2NO4, CAS 2138164-91-5
3-{1,4-Dioxa-7-azaspiro[4.5]decan-7-yl}-2,2-difluoropropanoic acid
CAS 2138164-91-5C10H15F2NO4
1,4-Dioxa-7-azaspiro[4.5]decane-7-sulfonyl chloride chemical structure, C7H12ClNO4S, CAS 2172477-09-5
1,4-Dioxa-7-azaspiro[4.5]decane-7-sulfonyl chloride
CAS 2172477-09-5C7H12ClNO4S
Propyl 1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate chemical structure, C11H19NO4, CAS 1869929-57-6
Propyl 1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate
CAS 1869929-57-6C11H19NO4