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Murcko scaffold

Ring system with 3 rings and 18 atoms

38 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
38
With full pages
8
Scaffold SMILES

c1ccc(Cc2noc(-c3ccccc3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Cc2noc(-c3ccccc3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 38 of 38 chemicals

3-(3,4-Dimethoxybenzyl)-5-(3,4-dimethoxyphenyl)-1,2,4-oxadiazole chemical structure, C19H20N2O5, CAS 168165-64-8
3-(3,4-Dimethoxybenzyl)-5-(3,4-dimethoxyphenyl)-1,2,4-oxadiazole
CAS 168165-64-8C19H20N2O5
3-Benzyl-5-(4-chlorophenyl)-1,2,4-oxadiazole chemical structure, C15H11ClN2O, CAS 313666-34-1
3-Benzyl-5-(4-chlorophenyl)-1,2,4-oxadiazole
CAS 313666-34-1C15H11ClN2O
3-Benzyl-5-(4-nitrophenyl)-1,2,4-oxadiazole chemical structure, C15H11N3O3, CAS 261735-33-5
3-Benzyl-5-(4-nitrophenyl)-1,2,4-oxadiazole
CAS 261735-33-5C15H11N3O3
3-(4-Chlorobenzyl)-5-(3-methoxyphenyl)-1,2,4-oxadiazole chemical structure, C16H13ClN2O2, CAS 331989-57-2
3-(4-Chlorobenzyl)-5-(3-methoxyphenyl)-1,2,4-oxadiazole
CAS 331989-57-2C16H13ClN2O2
3-(2-Methoxybenzyl)-5-(3-nitrophenyl)-1,2,4-oxadiazole chemical structure, C16H13N3O4, CAS 378217-57-3
3-(2-Methoxybenzyl)-5-(3-nitrophenyl)-1,2,4-oxadiazole
CAS 378217-57-3C16H13N3O4
3-(4-Chlorobenzyl)-5-(3,5-dimethoxyphenyl)-1,2,4-oxadiazole chemical structure, C17H15ClN2O3, CAS 767322-60-1
3-(4-Chlorobenzyl)-5-(3,5-dimethoxyphenyl)-1,2,4-oxadiazole
CAS 767322-60-1C17H15ClN2O3
3-[(3,4-Dimethoxyphenyl)methyl]-5-(4-nitrophenyl)-1,2,4-oxadiazole chemical structure, C17H15N3O5, CAS 381708-18-5
3-[(3,4-Dimethoxyphenyl)methyl]-5-(4-nitrophenyl)-1,2,4-oxadiazole
CAS 381708-18-5C17H15N3O5
5-(4-Bromophenyl)-3-(2-methoxybenzyl)-1,2,4-oxadiazole chemical structure, C16H13BrN2O2, CAS 425373-49-5
5-(4-Bromophenyl)-3-(2-methoxybenzyl)-1,2,4-oxadiazole
CAS 425373-49-5C16H13BrN2O2
3-(2-Chloro-6-fluorobenzyl)-5-phenyl-1,2,4-oxadiazole chemical structure, C15H10ClFN2O, CAS 6180-87-6
3-(2-Chloro-6-fluorobenzyl)-5-phenyl-1,2,4-oxadiazole
CAS 6180-87-6C15H10ClFN2O
3-(2-Chlorobenzyl)-5-(4-nitrophenyl)-1,2,4-oxadiazole chemical structure, C15H10ClN3O3, CAS 364749-62-2
3-(2-Chlorobenzyl)-5-(4-nitrophenyl)-1,2,4-oxadiazole
CAS 364749-62-2C15H10ClN3O3
3-(2-Chloro-6-fluorobenzyl)-5-(4-propylphenyl)-1,2,4-oxadiazole chemical structure, C18H16ClFN2O, CAS 6136-52-3
3-(2-Chloro-6-fluorobenzyl)-5-(4-propylphenyl)-1,2,4-oxadiazole
CAS 6136-52-3C18H16ClFN2O
5-(4-Bromophenyl)-3-(4-methoxybenzyl)-1,2,4-oxadiazole chemical structure, C16H13BrN2O2, CAS 425375-03-7
5-(4-Bromophenyl)-3-(4-methoxybenzyl)-1,2,4-oxadiazole
CAS 425375-03-7C16H13BrN2O2
1,2,4-Oxadiazole, 5-(4-chlorophenyl)-3-[(4-methoxyphenyl)methyl]- chemical structure, C16H13ClN2O2, CAS 61886-14-4
1,2,4-Oxadiazole, 5-(4-chlorophenyl)-3-[(4-methoxyphenyl)methyl]-
CAS 61886-14-4C16H13ClN2O2
5-(2-Chlorophenyl)-3-(4-methoxybenzyl)-1,2,4-oxadiazole chemical structure, C16H13ClN2O2, CAS 425411-10-5
5-(2-Chlorophenyl)-3-(4-methoxybenzyl)-1,2,4-oxadiazole
CAS 425411-10-5C16H13ClN2O2
3-(2-Chlorobenzyl)-5-(4-fluorophenyl)-1,2,4-oxadiazole chemical structure, C15H10ClFN2O, CAS 425412-00-6
3-(2-Chlorobenzyl)-5-(4-fluorophenyl)-1,2,4-oxadiazole
CAS 425412-00-6C15H10ClFN2O
3-(4-Chlorobenzyl)-5-(3,4-dimethoxyphenyl)-1,2,4-oxadiazole chemical structure, C17H15ClN2O3, CAS 864717-20-4
3-(4-Chlorobenzyl)-5-(3,4-dimethoxyphenyl)-1,2,4-oxadiazole
CAS 864717-20-4C17H15ClN2O3
3-[(4-Chlorophenyl)methyl]-5-(3-nitrophenyl)-1,2,4-oxadiazole chemical structure, C15H10ClN3O3, CAS 864717-28-2
3-[(4-Chlorophenyl)methyl]-5-(3-nitrophenyl)-1,2,4-oxadiazole
CAS 864717-28-2C15H10ClN3O3
3-(2,4-Dichlorobenzyl)-5-(4-fluorophenyl)-1,2,4-oxadiazole chemical structure, C15H9Cl2FN2O, CAS 701950-88-1
3-(2,4-Dichlorobenzyl)-5-(4-fluorophenyl)-1,2,4-oxadiazole
CAS 701950-88-1C15H9Cl2FN2O
3-[(2-Chloro-6-fluorophenyl)methyl]-5-(4-ethoxyphenyl)-1,2,4-oxadiazole chemical structure, C17H14ClFN2O2, CAS 6132-92-9
3-[(2-Chloro-6-fluorophenyl)methyl]-5-(4-ethoxyphenyl)-1,2,4-oxadiazole
CAS 6132-92-9C17H14ClFN2O2
5-(4-Bromophenyl)-3-(2-chloro-6-fluorobenzyl)-1,2,4-oxadiazole chemical structure, C15H9BrClFN2O, CAS 425374-34-1
5-(4-Bromophenyl)-3-(2-chloro-6-fluorobenzyl)-1,2,4-oxadiazole
CAS 425374-34-1C15H9BrClFN2O
5-(2-Bromophenyl)-3-[(3,4-dimethoxyphenyl)methyl]-1,2,4-oxadiazole chemical structure, C17H15BrN2O3, CAS 6153-94-2
5-(2-Bromophenyl)-3-[(3,4-dimethoxyphenyl)methyl]-1,2,4-oxadiazole
CAS 6153-94-2C17H15BrN2O3
3-[(2,4-Dichlorophenyl)methyl]-5-(3,4,5-triethoxyphenyl)-1,2,4-oxadiazole chemical structure, C21H22Cl2N2O4, CAS 690983-66-5
3-[(2,4-Dichlorophenyl)methyl]-5-(3,4,5-triethoxyphenyl)-1,2,4-oxadiazole
CAS 690983-66-5C21H22Cl2N2O4
3-(2-Methoxybenzyl)-5-(4-nitrophenyl)-1,2,4-oxadiazole chemical structure, C16H13N3O4, CAS 425401-61-2
3-(2-Methoxybenzyl)-5-(4-nitrophenyl)-1,2,4-oxadiazole
CAS 425401-61-2C16H13N3O4
3-(2,4-Dichlorobenzyl)-5-(4-iodophenyl)-1,2,4-oxadiazole chemical structure, C15H9Cl2IN2O, CAS 578733-23-0
3-(2,4-Dichlorobenzyl)-5-(4-iodophenyl)-1,2,4-oxadiazole
CAS 578733-23-0C15H9Cl2IN2O