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Murcko scaffold

Ring system with 3 rings and 24 atoms

33 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
33
With full pages
4
Scaffold SMILES

O=C(COC(=O)C1CC(=O)N(c2ccccc2)C1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COC(=O)C1CC(=O)N(c2ccccc2)C1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 33 of 33 chemicals

2-(3-Methoxyphenyl)-2-oxoethyl 1-(4-methoxyphenyl)-5-oxo-3-pyrrolidinecarboxylate chemical structure, C21H21NO6, CAS 726139-83-9
2-(3-Methoxyphenyl)-2-oxoethyl 1-(4-methoxyphenyl)-5-oxo-3-pyrrolidinecarboxylate
CAS 726139-83-9C21H21NO6
2-(4-Bromophenyl)-2-oxoethyl 1-(2-methylphenyl)-5-oxopyrrolidine-3-carboxylate chemical structure, C20H18BrNO4, CAS 352454-18-3
2-(4-Bromophenyl)-2-oxoethyl 1-(2-methylphenyl)-5-oxopyrrolidine-3-carboxylate
CAS 352454-18-3C20H18BrNO4
2-Oxo-2-phenylethyl 1-(4-chlorophenyl)-5-oxopyrrolidine-3-carboxylate chemical structure, C19H16ClNO4, CAS 339322-43-9
2-Oxo-2-phenylethyl 1-(4-chlorophenyl)-5-oxopyrrolidine-3-carboxylate
CAS 339322-43-9C19H16ClNO4
2-(4-Chlorophenyl)-2-oxoethyl 1-(4-bromophenyl)-5-oxopyrrolidine-3-carboxylate chemical structure, C19H15BrClNO4, CAS 331759-15-0
2-(4-Chlorophenyl)-2-oxoethyl 1-(4-bromophenyl)-5-oxopyrrolidine-3-carboxylate
CAS 331759-15-0C19H15BrClNO4
2-(4-Bromophenyl)-2-oxoethyl 1-(4-methoxyphenyl)-5-oxo-3-pyrrolidinecarboxylate chemical structure, C20H18BrNO5, CAS 298216-92-9
2-(4-Bromophenyl)-2-oxoethyl 1-(4-methoxyphenyl)-5-oxo-3-pyrrolidinecarboxylate
CAS 298216-92-9C20H18BrNO5
2-(4-Chlorophenyl)-2-oxoethyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate chemical structure, C19H15ClFNO4, CAS 331759-16-1
2-(4-Chlorophenyl)-2-oxoethyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate
CAS 331759-16-1C19H15ClFNO4
2-(4-Bromophenyl)-2-oxoethyl 1-(4-methylphenyl)-5-oxo-3-pyrrolidinecarboxylate chemical structure, C20H18BrNO4, CAS 331982-74-2
2-(4-Bromophenyl)-2-oxoethyl 1-(4-methylphenyl)-5-oxo-3-pyrrolidinecarboxylate
CAS 331982-74-2C20H18BrNO4
2-(4-Chlorophenyl)-2-oxoethyl 1-(4-ethoxyphenyl)-5-oxopyrrolidine-3-carboxylate chemical structure, C21H20ClNO5, CAS 345367-44-4
2-(4-Chlorophenyl)-2-oxoethyl 1-(4-ethoxyphenyl)-5-oxopyrrolidine-3-carboxylate
CAS 345367-44-4C21H20ClNO5
2-(4-Bromophenyl)-2-oxoethyl 1-(3-chloro-4-methylphenyl)-5-oxopyrrolidine-3-carboxylate chemical structure, C20H17BrClNO4, CAS 345367-43-3
2-(4-Bromophenyl)-2-oxoethyl 1-(3-chloro-4-methylphenyl)-5-oxopyrrolidine-3-carboxylate
CAS 345367-43-3C20H17BrClNO4
2-(4-Fluorophenyl)-2-oxoethyl 1-(3-methylphenyl)-5-oxo-3-pyrrolidinecarboxylate chemical structure, C20H18FNO4, CAS 433252-21-2
2-(4-Fluorophenyl)-2-oxoethyl 1-(3-methylphenyl)-5-oxo-3-pyrrolidinecarboxylate
CAS 433252-21-2C20H18FNO4
2-(4-Chlorophenyl)-2-oxoethyl 1-(4-ethylphenyl)-5-oxopyrrolidine-3-carboxylate chemical structure, C21H20ClNO4, CAS 433259-61-1
2-(4-Chlorophenyl)-2-oxoethyl 1-(4-ethylphenyl)-5-oxopyrrolidine-3-carboxylate
CAS 433259-61-1C21H20ClNO4
2-(4-Bromophenyl)-2-oxoethyl 1-(4-butylphenyl)-5-oxopyrrolidine-3-carboxylate chemical structure, C23H24BrNO4, CAS 433310-83-9
2-(4-Bromophenyl)-2-oxoethyl 1-(4-butylphenyl)-5-oxopyrrolidine-3-carboxylate
CAS 433310-83-9C23H24BrNO4
2-Oxo-2-phenylethyl 1-(4-methoxyphenyl)-5-oxo-3-pyrrolidinecarboxylate chemical structure, C20H19NO5, CAS 433311-18-3
2-Oxo-2-phenylethyl 1-(4-methoxyphenyl)-5-oxo-3-pyrrolidinecarboxylate
CAS 433311-18-3C20H19NO5
2-(4-Fluorophenyl)-2-oxoethyl 1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxylate chemical structure, C20H18FNO5, CAS 433312-32-4
2-(4-Fluorophenyl)-2-oxoethyl 1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxylate
CAS 433312-32-4C20H18FNO5
2-(4-Bromophenyl)-2-oxoethyl 1-(3,4-dimethylphenyl)-5-oxopyrrolidine-3-carboxylate chemical structure, C21H20BrNO4, CAS 433315-87-8
2-(4-Bromophenyl)-2-oxoethyl 1-(3,4-dimethylphenyl)-5-oxopyrrolidine-3-carboxylate
CAS 433315-87-8C21H20BrNO4
2-Oxo-2-phenylethyl 1-(3-methylphenyl)-5-oxo-3-pyrrolidinecarboxylate chemical structure, C20H19NO4, CAS 433319-34-7
2-Oxo-2-phenylethyl 1-(3-methylphenyl)-5-oxo-3-pyrrolidinecarboxylate
CAS 433319-34-7C20H19NO4
[2-(4-Bromophenyl)-2-oxoethyl] 5-oxo-1-(4-propan-2-ylphenyl)pyrrolidine-3-carboxylate chemical structure, C22H22BrNO4, CAS 433325-60-1
[2-(4-Bromophenyl)-2-oxoethyl] 5-oxo-1-(4-propan-2-ylphenyl)pyrrolidine-3-carboxylate
CAS 433325-60-1C22H22BrNO4
2-(4-Bromophenyl)-2-oxoethyl 5-oxo-1-(4-propoxyphenyl)pyrrolidine-3-carboxylate chemical structure, C22H22BrNO5, CAS 592477-48-0
2-(4-Bromophenyl)-2-oxoethyl 5-oxo-1-(4-propoxyphenyl)pyrrolidine-3-carboxylate
CAS 592477-48-0C22H22BrNO5
2-(4-Bromophenyl)-2-oxoethyl 1-(2,5-dimethylphenyl)-5-oxopyrrolidine-3-carboxylate chemical structure, C21H20BrNO4, CAS 340320-10-7
2-(4-Bromophenyl)-2-oxoethyl 1-(2,5-dimethylphenyl)-5-oxopyrrolidine-3-carboxylate
CAS 340320-10-7C21H20BrNO4
2-(4-Fluorophenyl)-2-oxoethyl 1-(4-methylphenyl)-5-oxo-3-pyrrolidinecarboxylate chemical structure, C20H18FNO4, CAS 510714-79-1
2-(4-Fluorophenyl)-2-oxoethyl 1-(4-methylphenyl)-5-oxo-3-pyrrolidinecarboxylate
CAS 510714-79-1C20H18FNO4
2-(4-Methoxyphenyl)-2-oxoethyl 1-(4-ethoxyphenyl)-5-oxo-3-pyrrolidinecarboxylate chemical structure, C22H23NO6, CAS 876714-78-2
2-(4-Methoxyphenyl)-2-oxoethyl 1-(4-ethoxyphenyl)-5-oxo-3-pyrrolidinecarboxylate
CAS 876714-78-2C22H23NO6
2-(4-Methylphenyl)-2-oxoethyl 1-(4-bromophenyl)-5-oxo-3-pyrrolidinecarboxylate chemical structure, C20H18BrNO4, CAS 847478-76-6
2-(4-Methylphenyl)-2-oxoethyl 1-(4-bromophenyl)-5-oxo-3-pyrrolidinecarboxylate
CAS 847478-76-6C20H18BrNO4
2-(4-Chlorophenyl)-2-oxoethyl 1-(3-methoxyphenyl)-5-oxo-3-pyrrolidinecarboxylate chemical structure, C20H18ClNO5, CAS 690227-95-3
2-(4-Chlorophenyl)-2-oxoethyl 1-(3-methoxyphenyl)-5-oxo-3-pyrrolidinecarboxylate
CAS 690227-95-3C20H18ClNO5
2-(3-Methoxyphenyl)-2-oxoethyl 1-(4-bromophenyl)-5-oxo-3-pyrrolidinecarboxylate chemical structure, C20H18BrNO5, CAS 847478-80-2
2-(3-Methoxyphenyl)-2-oxoethyl 1-(4-bromophenyl)-5-oxo-3-pyrrolidinecarboxylate
CAS 847478-80-2C20H18BrNO5