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Murcko scaffold

Ring system with 3 rings and 18 atoms

26 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
26
With full pages
3
Scaffold SMILES

c1ccc(-c2csc(Nc3cccnc3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2csc(Nc3cccnc3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

(4-(3,4-Dichlorophenyl)(2,5-thiazolyl))-3-pyridylamine chemical structure, C14H9Cl2N3S, CAS 497060-07-8
(4-(3,4-Dichlorophenyl)(2,5-thiazolyl))-3-pyridylamine
CAS 497060-07-8C14H9Cl2N3S
(4-(4-Bromophenyl)(2,5-thiazolyl))-3-pyridylamine chemical structure, C14H10BrN3S, CAS 256471-39-3
(4-(4-Bromophenyl)(2,5-thiazolyl))-3-pyridylamine
CAS 256471-39-3C14H10BrN3S
4-(4-Bromophenyl)-3-(2-methoxyethyl)-N-pyridin-3-yl-1,3-thiazol-2-imine chemical structure, C17H16BrN3OS, CAS 1049985-78-5
4-(4-Bromophenyl)-3-(2-methoxyethyl)-N-pyridin-3-yl-1,3-thiazol-2-imine
CAS 1049985-78-5C17H16BrN3OS
(4-(4-Chloro-3-methylphenyl)(2,5-thiazolyl))-3-pyridylamine chemical structure, C15H12ClN3S, CAS 1023483-44-4
(4-(4-Chloro-3-methylphenyl)(2,5-thiazolyl))-3-pyridylamine
CAS 1023483-44-4C15H12ClN3S
N-[4-[2-(Pyridin-3-ylamino)-1,3-thiazol-4-yl]phenyl]acetamide chemical structure, C16H14N4OS, CAS 1023536-90-4
N-[4-[2-(Pyridin-3-ylamino)-1,3-thiazol-4-yl]phenyl]acetamide
CAS 1023536-90-4C16H14N4OS
4-(4-Fluorophenyl)-5-methyl-N-(pyridin-3-yl)thiazol-2-amine chemical structure, C15H12FN3S, CAS 914663-94-8
4-(4-Fluorophenyl)-5-methyl-N-(pyridin-3-yl)thiazol-2-amine
CAS 914663-94-8C15H12FN3S
N-(4-(2-(Pyridin-3-ylamino)thiazol-4-yl)phenyl)pent-4-enamide chemical structure, C19H18N4OS, CAS 1797285-12-1
N-(4-(2-(Pyridin-3-ylamino)thiazol-4-yl)phenyl)pent-4-enamide
CAS 1797285-12-1C19H18N4OS
N-(4-(2-(Pyridin-3-ylamino)thiazol-4-yl)phenyl)pivalamide chemical structure, C19H20N4OS, CAS 1797557-86-8
N-(4-(2-(Pyridin-3-ylamino)thiazol-4-yl)phenyl)pivalamide
CAS 1797557-86-8C19H20N4OS
2-Ethoxy-N-(4-(2-(pyridin-3-ylamino)thiazol-4-yl)phenyl)acetamide chemical structure, C18H18N4O2S, CAS 1797891-11-2
2-Ethoxy-N-(4-(2-(pyridin-3-ylamino)thiazol-4-yl)phenyl)acetamide
CAS 1797891-11-2C18H18N4O2S
Ethyl 4-oxo-4-((4-(2-(pyridin-3-ylamino)thiazol-4-yl)phenyl)amino)butanoate chemical structure, C20H20N4O3S, CAS 1797727-52-6
Ethyl 4-oxo-4-((4-(2-(pyridin-3-ylamino)thiazol-4-yl)phenyl)amino)butanoate
CAS 1797727-52-6C20H20N4O3S
Ethyl (4-(2-(pyridin-3-ylamino)thiazol-4-yl)phenyl)carbamate chemical structure, C17H16N4O2S, CAS 1797558-01-0
Ethyl (4-(2-(pyridin-3-ylamino)thiazol-4-yl)phenyl)carbamate
CAS 1797558-01-0C17H16N4O2S
2-Methyl-1-oxo-1-((4-(2-(pyridin-3-ylamino)thiazol-4-yl)phenyl)amino)propan-2-yl acetate chemical structure, C20H20N4O3S, CAS 1797334-49-6
2-Methyl-1-oxo-1-((4-(2-(pyridin-3-ylamino)thiazol-4-yl)phenyl)amino)propan-2-yl acetate
CAS 1797334-49-6C20H20N4O3S
3-Methyl-N-(4-(2-(pyridin-3-ylamino)thiazol-4-yl)phenyl)but-2-enamide chemical structure, C19H18N4OS, CAS 1797094-58-6
3-Methyl-N-(4-(2-(pyridin-3-ylamino)thiazol-4-yl)phenyl)but-2-enamide
CAS 1797094-58-6C19H18N4OS
3,3,3-Trifluoro-N-(4-(2-(pyridin-3-ylamino)thiazol-4-yl)phenyl)propanamide chemical structure, C17H13F3N4OS, CAS 1797641-36-1
3,3,3-Trifluoro-N-(4-(2-(pyridin-3-ylamino)thiazol-4-yl)phenyl)propanamide
CAS 1797641-36-1C17H13F3N4OS
4,4,4-Trifluoro-N-(4-(2-(pyridin-3-ylamino)thiazol-4-yl)phenyl)butanamide chemical structure, C18H15F3N4OS, CAS 1797903-56-0
4,4,4-Trifluoro-N-(4-(2-(pyridin-3-ylamino)thiazol-4-yl)phenyl)butanamide
CAS 1797903-56-0C18H15F3N4OS
N-(4-(2-(Pyridin-3-ylamino)thiazol-4-yl)phenyl)ethanesulfonamide chemical structure, C16H16N4O2S2, CAS 1797558-20-3
N-(4-(2-(Pyridin-3-ylamino)thiazol-4-yl)phenyl)ethanesulfonamide
CAS 1797558-20-3C16H16N4O2S2
N-(4-(2-(Pyridin-3-ylamino)thiazol-4-yl)phenyl)propane-1-sulfonamide chemical structure, C17H18N4O2S2, CAS 1797891-19-0
N-(4-(2-(Pyridin-3-ylamino)thiazol-4-yl)phenyl)propane-1-sulfonamide
CAS 1797891-19-0C17H18N4O2S2
N-(4-(2-(Pyridin-3-ylamino)thiazol-4-yl)phenyl)butane-1-sulfonamide chemical structure, C18H20N4O2S2, CAS 1796947-12-0
N-(4-(2-(Pyridin-3-ylamino)thiazol-4-yl)phenyl)butane-1-sulfonamide
CAS 1796947-12-0C18H20N4O2S2
4-(4-Aminophenyl)-N-(pyridin-3-yl)thiazol-2-amine chemical structure, C14H12N4S, CAS 572889-21-5
4-(4-Aminophenyl)-N-(pyridin-3-yl)thiazol-2-amine
CAS 572889-21-5C14H12N4S
N-(4-(2-((6-Fluoropyridin-3-yl)amino)-1,3-thiazol-4-yl)phenyl)methanesulfonamide chemical structure, C15H13FN4O2S2, CAS 2490398-56-4
N-(4-(2-((6-Fluoropyridin-3-yl)amino)-1,3-thiazol-4-yl)phenyl)methanesulfonamide
CAS 2490398-56-4C15H13FN4O2S2
N-(4-{2-[(6-Chloropyridin-3-yl)amino]-1,3-thiazol-4-yl}phenyl)methanesulfonamide hydrochloride chemical structure, C15H14Cl2N4O2S2, CAS 2613383-17-6
N-(4-{2-[(6-Chloropyridin-3-yl)amino]-1,3-thiazol-4-yl}phenyl)methanesulfonamide hydrochloride
CAS 2613383-17-6C15H14Cl2N4O2S2
6-Chloro-N-[4-(4-ethenylphenyl)-1,3-thiazol-2-yl]pyridin-3-amine hydrochloride chemical structure, C16H13Cl2N3S, CAS 2680536-02-9
6-Chloro-N-[4-(4-ethenylphenyl)-1,3-thiazol-2-yl]pyridin-3-amine hydrochloride
CAS 2680536-02-9C16H13Cl2N3S
6-Chloro-N-[4-(3,4,5-trifluorophenyl)-1,3-thiazol-2-yl]pyridin-3-amine hydrochloride chemical structure, C14H8Cl2F3N3S, CAS 2680527-98-2
6-Chloro-N-[4-(3,4,5-trifluorophenyl)-1,3-thiazol-2-yl]pyridin-3-amine hydrochloride
CAS 2680527-98-2C14H8Cl2F3N3S
N-[4-(4-Bromo-2,5-dimethylphenyl)-1,3-thiazol-2-yl]-6-chloropyridin-3-amine hydrochloride chemical structure, C16H14BrCl2N3S, CAS 2680543-32-0
N-[4-(4-Bromo-2,5-dimethylphenyl)-1,3-thiazol-2-yl]-6-chloropyridin-3-amine hydrochloride
CAS 2680543-32-0C16H14BrCl2N3S