Murcko scaffold
Benzyl 2-oxo-2-(pyrrolidin-1-yl)ethylcarbamate scaffold
75 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 19
- Chemicals
- 75
- With full pages
- 5
Scaffold SMILES
O=C(NCC(=O)N1CCCC1)OCc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 75 chemicals
Carbobenzoxyglycyl-L-proline
CAS 68047-33-6C15H18N2O5
N-Benzyloxycarbonylvalylprolinal
CAS 91650-00-9C18H24N2O4
((4-Methoxyphenyl)carbonyl)-valyl-N-(3-(1,1,1-trifluoro-2-hydroxy-4-methylpentyl))prolinamide
CAS 105080-60-2C24H32F3N3O5
N-Benzyloxycarbonylalanylprolinal
CAS 108708-27-6C16H20N2O4
![Methyl 1-[2-(phenylmethoxycarbonylamino)butanoyl]pyrrolidine-2-carboxylate chemical structure, C18H24N2O5, CAS 78657-92-8](/s/NMRWAZHKEPQYKR-UHFFFAOYSA-N.svg)
Methyl 1-[2-(phenylmethoxycarbonylamino)butanoyl]pyrrolidine-2-carboxylate
CAS 78657-92-8C18H24N2O5
![Methyl N-[(benzyloxy)carbonyl]glycylprolinate chemical structure, C16H20N2O5, CAS 66449-90-9](/s/LYMTYKMJFYZNBN-UHFFFAOYSA-N.svg)
Methyl N-[(benzyloxy)carbonyl]glycylprolinate
CAS 66449-90-9C16H20N2O5
![1-[2-(Phenylmethoxycarbonylamino)propanoyl]pyrrolidine-2-carboxylic acid chemical structure, C16H20N2O5, CAS 1682648-28-7](/s/RSSOZTMMMIWOJB-UHFFFAOYSA-N.svg)
1-[2-(Phenylmethoxycarbonylamino)propanoyl]pyrrolidine-2-carboxylic acid
CAS 1682648-28-7C16H20N2O5
(Benzyloxycarbonyl)glycyl-L-proline
CAS 1160-54-9C15H18N2O5
Carbamic acid, (2-(2-formyl-1-pyrrolidinyl)-2-oxoethyl)-, phenylmethyl ester, (S)-
CAS 99952-43-9C15H18N2O4
Carbamic acid, (1-((2-formyl-1-pyrrolidinyl)carbonyl)-3-methylbutyl)-, phenylmethyl ester, (S-(R*,R*))-
CAS 99952-44-0C19H26N2O4
![1-(2-{[(Benzyloxy)carbonyl]amino}propanoyl)-4-hydroxypyrrolidine-2-carboxylic acid chemical structure, C16H20N2O6, CAS 22049-33-8](/s/SKAZUZUAPBSAJR-UHFFFAOYSA-N.svg)
1-(2-{[(Benzyloxy)carbonyl]amino}propanoyl)-4-hydroxypyrrolidine-2-carboxylic acid
CAS 22049-33-8C16H20N2O6
t-Butyl-N-carbobenzyloxy-L-aspartyl-L-proline
C21H28N2O7
Z-Ala prolinal
CAS 21027-01-0C16H20N2O5
Cbz-L-alanyl-D-proline
CAS 116939-94-7C16H20N2O5
(R)-1-(2-(((Benzyloxy)carbonyl)amino)acetyl)pyrrolidine-2-carboxylic acid
CAS 114501-87-0C15H18N2O5
Z-Gly-pro-ala-OH
CAS 5891-41-8C18H23N3O6
![Methyl (S)-1-[(R)-2-(Cbz-amino)propanoyl]pyrrolidine-2-carboxylate chemical structure, C17H22N2O5, CAS 22209-85-4](/s/FILANUFALHCKNQ-OCCSQVGLSA-N.svg)
Methyl (S)-1-[(R)-2-(Cbz-amino)propanoyl]pyrrolidine-2-carboxylate
CAS 22209-85-4C17H22N2O5
Z-Val-pro-OH
CAS 53331-43-4C18H24N2O5
![L-Proline, N-[(phenylmethoxy)carbonyl]-L-isoleucyl- chemical structure, C19H26N2O5, CAS 13211-37-5](/s/ABVHKUUPJNVPLM-BPUTZDHNSA-N.svg)
L-Proline, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-
CAS 13211-37-5C19H26N2O5
Z-Ala-pro-gly-OH
CAS 23458-25-5C18H23N3O6
Benzyl 2-oxo-2-(pyrrolidin-1-yl)ethylcarbamate
CAS 56414-65-4C14H18N2O3
![L-Proline, 1-[N5-[imino(nitroamino)methyl]-N2-[(phenylmethoxy)carbonyl]-L-ornithyl]-, methyl ester chemical structure, C20H28N6O7, CAS 3268-81-3](/s/XJNNICYYTPWOMR-HOTGVXAUSA-N.svg)
L-Proline, 1-[N5-[imino(nitroamino)methyl]-N2-[(phenylmethoxy)carbonyl]-L-ornithyl]-, methyl ester
CAS 3268-81-3C20H28N6O7
![L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-alanyl-N-propyl- chemical structure, C19H27N3O4, CAS 84899-62-7](/s/SQDQBJRBHVMWLN-HOCLYGCPSA-N.svg)
L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-alanyl-N-propyl-
CAS 84899-62-7C19H27N3O4
![L-Proline, 1-[N-[[(4-methoxyphenyl)methoxy]carbonyl]-L-alanyl]- chemical structure, C17H22N2O6, CAS 65001-87-8](/s/LITKCHHONKQEQM-FZMZJTMJSA-N.svg)
L-Proline, 1-[N-[[(4-methoxyphenyl)methoxy]carbonyl]-L-alanyl]-
CAS 65001-87-8C17H22N2O6
- Benzyl N-[(2S)-1-[(2S)-2-(2-methylpropylcarbamoyl)pyrrolidin-1-yl]-1-oxopropan-2-yl]carbamate116287-67-3C20H29N3O4
- Z-Ala-pro-leu-OH108074-19-7C22H31N3O6
- (S)-Methyl 1-((S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoyl)pyrrolidine-2-carboxylate51827-14-6C19H26N2O5
- 2-[[1-[2-(Phenylmethoxycarbonylamino)acetyl]pyrrolidine-2-carbonyl]amino]propanoic acidC18H23N3O6
- Z-Leu-Pro-OH . CHA116939-86-7C19H26N2O5
- Benzyl DL-N-[1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]carbamate56487-30-0C15H20N2O3
- Carbamic acid, [3-methyl-1-(1-pyrrolidinylcarbonyl)butyl]-, phenylmethyl ester, (S)-56414-66-5C18H26N2O3
- Z-Gly-Pro-Leu-Gly2646-64-2C23H32N4O7
- N-[(Phenylmethoxy)carbonyl]-D-valyl-L-prolyl-N-methylglycine 1,1-dimethylethyl ester27483-27-8C25H37N3O6
- Methyl (2R)-1-(2-{[(benzyloxy)carbonyl]amino}acetyl)pyrrolidine-2-carboxylate2365390-46-9C16H20N2O5
- 2-[[1-[2-(Phenylmethoxycarbonylamino)propanoyl]pyrrolidine-2-carbonyl]amino]acetic acidC18H23N3O6
- Carbamic acid, [1-[(2-formyl-1-pyrrolidinyl)carbonyl]-2-methylpropyl]-, phenylmethyl ester108708-24-3C18H24N2O4
- N-Benzyloxycarbonyl-L-lysinyl-L-proline42001-60-5C19H27N3O5
- Cbz-Asp(OtBu)(OtBu)-D-Pro-OHC21H28N2O7
- (2S)-1-[(2S)-4-[(2-Methylpropan-2-yl)oxy]-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]pyrrolidine-2-carboxylic acid4583-13-5C21H28N2O7
- N-[(Phenylmethoxy)carbonyl]-L-alanyl-L-proline 1,1-dimethylethyl ester27544-35-0C20H28N2O5
- N-Cbz-Ala-Pro-Leu dicyclohexylammonium salt108321-20-6C34H54N4O6
- L-Leucine, N-(1-(N-((phenylmethoxy)carbonyl)glycyl)-L-prolyl)-2646-63-1C21H29N3O6
- (2S,4R)-1-(2-{[(Benzyloxy)carbonyl]amino}acetyl)-4-hydroxypyrrolidine-2-carboxylic acid22029-01-2C15H18N2O6
- L-Proline, N-[(phenylmethoxy)carbonyl]glycyl-2-methyl-869001-86-5C16H20N2O5
- L-Proline, N-[(phenylmethoxy)carbonyl]glycyl-2-methyl-, methyl ester847952-40-3C17H22N2O5
- tert-Butyl [(S)-2-(Cbz-amino)-3,3-dimethylbutanoyl]-L-prolinate374773-66-7C23H34N2O5
- Cbz-Gly-aMePro-Glu-OH2603450-03-7C21H27N3O8
- 1-[6-Amino-2-(phenylmethoxycarbonylamino)hexanoyl]pyrrolidine-2-carboxylic acidC19H27N3O5
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(NCNC(=S)Nc1ccccc1)c1ccco120 chemicals![Scaffold O=C(CCc1cn[nH]c1)NN=Cc1ccccc1](/scaffold/CJESFXAZXMEJBY-UHFFFAOYSA-N/structure.svg)
O=C(CCc1cn[nH]c1)NN=Cc1ccccc114 chemicals
O=C(CNCCCc1ccccc1)N1CCCC114 chemicals
O=C(COc1ccccc1)NN=Cc1ccco110 chemicals
S=C(NCCCn1ccnc1)Nc1ccccc110 chemicals
O=C(COC(=O)c1cccs1)NCc1ccccc19 chemicals
O=C(CCC(=O)Nc1nncs1)Nc1ccccc18 chemicals
O=C(COC(=O)CC1CCCC1)Nc1ccccc18 chemicals
O=C(CCNC(=O)c1ccco1)Nc1ccccc18 chemicals
O=C(NNC(=S)NCc1ccccc1)c1ccsc17 chemicals
O=C(CCc1ccccc1)NCC(=O)N1CCCC17 chemicals
O=C1CCCN1CCCNC(=S)Nc1ccccc17 chemicals