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Murcko scaffold

Ring system with 3 rings and 22 atoms

376 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
376
With full pages
5
Scaffold SMILES

O=C(Nc1ccccc1)C1=CNC(=S)NC1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)C1=CNC(=S)NC1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 193 to 240 of 376 chemicals

N-(2,4-Dimethoxyphenyl)-4-(4-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C20H20FN3O3S, CAS 431074-63-4
N-(2,4-Dimethoxyphenyl)-4-(4-fluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 431074-63-4C20H20FN3O3S
N-(2,4-Dimethylphenyl)-4-(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20FN3OS, CAS 380352-83-0
N-(2,4-Dimethylphenyl)-4-(2-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 380352-83-0C20H20FN3OS
4-(2-Chlorophenyl)-N-(3,4-difluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H14ClF2N3OS, CAS 380491-24-7
4-(2-Chlorophenyl)-N-(3,4-difluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 380491-24-7C18H14ClF2N3OS
N-(2,4-Dimethylphenyl)-6-methyl-2-thioxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C23H27N3O4S, CAS 431075-82-0
N-(2,4-Dimethylphenyl)-6-methyl-2-thioxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 431075-82-0C23H27N3O4S
4-(2,4-Dichlorophenyl)-N-(3,4-difluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C18H13Cl2F2N3OS, CAS 380352-39-6
4-(2,4-Dichlorophenyl)-N-(3,4-difluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 380352-39-6C18H13Cl2F2N3OS
4-(4-Bromophenyl)-N-(2,4-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20BrN3OS, CAS 379253-08-4
4-(4-Bromophenyl)-N-(2,4-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 379253-08-4C20H20BrN3OS
N-(2,4-Dimethoxyphenyl)-6-methyl-2-thioxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C23H27N3O6S, CAS 431883-31-7
N-(2,4-Dimethoxyphenyl)-6-methyl-2-thioxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 431883-31-7C23H27N3O6S
4-(3-Chlorophenyl)-N-(2,4-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20ClN3OS, CAS 379252-38-7
4-(3-Chlorophenyl)-N-(2,4-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 379252-38-7C20H20ClN3OS
N-(2,4-Dimethylphenyl)-4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C22H25N3O3S, CAS 431884-55-8
N-(2,4-Dimethylphenyl)-4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 431884-55-8C22H25N3O3S
4-(2-Bromophenyl)-N-(2,4-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20BrN3OS, CAS 431884-61-6
4-(2-Bromophenyl)-N-(2,4-dimethylphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 431884-61-6C20H20BrN3OS
N-(3,4-Difluorophenyl)-6-methyl-4-(3-nitrophenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C18H14F2N4O3S, CAS 379253-14-2
N-(3,4-Difluorophenyl)-6-methyl-4-(3-nitrophenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 379253-14-2C18H14F2N4O3S
N-(3,4-Difluorophenyl)-4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C20H19F2N3O3S, CAS 431886-01-0
N-(3,4-Difluorophenyl)-4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 431886-01-0C20H19F2N3O3S
N-(2,4-Dimethylphenyl)-4-(3-methoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C21H23N3O2S, CAS 431886-55-4
N-(2,4-Dimethylphenyl)-4-(3-methoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 431886-55-4C21H23N3O2S
4-(2,4-Dichlorophenyl)-N-(2,4-dimethoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C20H19Cl2N3O3S, CAS 431886-59-8
4-(2,4-Dichlorophenyl)-N-(2,4-dimethoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 431886-59-8C20H19Cl2N3O3S
N-(2,4-Dimethoxyphenyl)-6-methyl-4-(4-methylphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C21H23N3O3S, CAS 431891-10-0
N-(2,4-Dimethoxyphenyl)-6-methyl-4-(4-methylphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 431891-10-0C21H23N3O3S
4-(3-Bromophenyl)-N-(3,4-difluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C18H14BrF2N3OS, CAS 431891-33-7
4-(3-Bromophenyl)-N-(3,4-difluorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 431891-33-7C18H14BrF2N3OS
N-(2,5-Dimethoxyphenyl)-4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide chemical structure, C22H25N3O5S, CAS 379252-64-9
N-(2,5-Dimethoxyphenyl)-4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide
CAS 379252-64-9C22H25N3O5S
N,4-bis(2,4-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C22H25N3O5S, CAS 431892-98-7
N,4-bis(2,4-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 431892-98-7C22H25N3O5S
N-(2,4-Dimethylphenyl)-6-methyl-4-(3-nitrophenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C20H20N4O3S, CAS 431893-65-1
N-(2,4-Dimethylphenyl)-6-methyl-4-(3-nitrophenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 431893-65-1C20H20N4O3S
N-(2,5-Dimethoxyphenyl)-4-(4-(dimethylamino)phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C22H26N4O3S, CAS 380434-38-8
N-(2,5-Dimethoxyphenyl)-4-(4-(dimethylamino)phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 380434-38-8C22H26N4O3S
N-(2,4-Dimethoxyphenyl)-6-[4-(dimethylamino)phenyl]-4-methyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxamide chemical structure, C22H26N4O3S, CAS 431895-83-9
N-(2,4-Dimethoxyphenyl)-6-[4-(dimethylamino)phenyl]-4-methyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxamide
CAS 431895-83-9C22H26N4O3S
N-(2,4-Dimethoxyphenyl)-4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C22H25N3O5S, CAS 431916-16-4
N-(2,4-Dimethoxyphenyl)-4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 431916-16-4C22H25N3O5S
N-(2,4-Dimethoxyphenyl)-4-(3,4-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C22H25N3O5S, CAS 440091-29-2
N-(2,4-Dimethoxyphenyl)-4-(3,4-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 440091-29-2C22H25N3O5S
4-(2-Bromophenyl)-N-(3,4-difluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H14BrF2N3OS, CAS 431917-36-1
4-(2-Bromophenyl)-N-(3,4-difluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 431917-36-1C18H14BrF2N3OS