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Murcko scaffold

Ring system with 3 rings and 21 atoms

16 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
16
With full pages
6
Scaffold SMILES

O=C1CC(Sc2nccc(=O)[nH]2)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(Sc2nccc(=O)[nH]2)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

3-[(4,6-Dihydroxy-5-propylpyrimidin-2-yl)sulfanyl]-1-(2,5-dimethoxyphenyl)pyrrolidine-2,5-dione chemical structure, C19H21N3O6S, CAS 878972-39-5
3-[(4,6-Dihydroxy-5-propylpyrimidin-2-yl)sulfanyl]-1-(2,5-dimethoxyphenyl)pyrrolidine-2,5-dione
CAS 878972-39-5C19H21N3O6S
Ethyl 4-{3-[(5-butyl-4,6-dihydroxypyrimidin-2-yl)sulfanyl]-2,5-dioxopyrrolidin-1-yl}benzoate chemical structure, C21H23N3O6S, CAS 674816-52-5
Ethyl 4-{3-[(5-butyl-4,6-dihydroxypyrimidin-2-yl)sulfanyl]-2,5-dioxopyrrolidin-1-yl}benzoate
CAS 674816-52-5C21H23N3O6S
1-(4-Ethoxyphenyl)-3-[(5-ethyl-4,6-dihydroxy-2-pyrimidinyl)thio]-2,5-pyrrolidinedione chemical structure, C18H19N3O5S, CAS 674294-41-8
1-(4-Ethoxyphenyl)-3-[(5-ethyl-4,6-dihydroxy-2-pyrimidinyl)thio]-2,5-pyrrolidinedione
CAS 674294-41-8C18H19N3O5S
1-(3-Chloro-4-methylphenyl)-3-[(4,6-dihydroxy-5-propyl-2-pyrimidinyl)thio]-2,5-pyrrolidinedione chemical structure, C18H18ClN3O4S, CAS 672331-44-1
1-(3-Chloro-4-methylphenyl)-3-[(4,6-dihydroxy-5-propyl-2-pyrimidinyl)thio]-2,5-pyrrolidinedione
CAS 672331-44-1C18H18ClN3O4S
1-(3-Chloro-4-fluorophenyl)-3-[(5-ethyl-4,6-dihydroxypyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione chemical structure, C16H13ClFN3O4S, CAS 674296-60-7
1-(3-Chloro-4-fluorophenyl)-3-[(5-ethyl-4,6-dihydroxypyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione
CAS 674296-60-7C16H13ClFN3O4S
3-[(4,6-Dihydroxy-5-methylpyrimidin-2-yl)sulfanyl]-1-phenylpyrrolidine-2,5-dione chemical structure, C15H13N3O4S, CAS 669746-90-1
3-[(4,6-Dihydroxy-5-methylpyrimidin-2-yl)sulfanyl]-1-phenylpyrrolidine-2,5-dione
CAS 669746-90-1C15H13N3O4S
3-[(5-Butyl-4,6-dihydroxypyrimidin-2-yl)sulfanyl]-1-(3-chloro-4-fluorophenyl)pyrrolidine-2,5-dione chemical structure, C18H17ClFN3O4S, CAS 833439-22-8
3-[(5-Butyl-4,6-dihydroxypyrimidin-2-yl)sulfanyl]-1-(3-chloro-4-fluorophenyl)pyrrolidine-2,5-dione
CAS 833439-22-8C18H17ClFN3O4S
1-(2-Ethoxyphenyl)-3-[(5-ethyl-4,6-dihydroxypyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione chemical structure, C18H19N3O5S, CAS 835891-56-0
1-(2-Ethoxyphenyl)-3-[(5-ethyl-4,6-dihydroxypyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione
CAS 835891-56-0C18H19N3O5S
1-(2,4-Dichlorophenyl)-3-[(5-ethyl-4,6-dihydroxypyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione chemical structure, C16H13Cl2N3O4S, CAS 838811-72-6
1-(2,4-Dichlorophenyl)-3-[(5-ethyl-4,6-dihydroxypyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione
CAS 838811-72-6C16H13Cl2N3O4S
3-[(4,6-Dihydroxy-5-methylpyrimidin-2-yl)sulfanyl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione chemical structure, C16H15N3O5S, CAS 838844-94-3
3-[(4,6-Dihydroxy-5-methylpyrimidin-2-yl)sulfanyl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione
CAS 838844-94-3C16H15N3O5S
1-(2,4-Dichlorophenyl)-3-[(4-hydroxy-5-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione chemical structure, C15H11Cl2N3O4S, CAS 674361-91-2
1-(2,4-Dichlorophenyl)-3-[(4-hydroxy-5-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]pyrrolidine-2,5-dione
CAS 674361-91-2C15H11Cl2N3O4S
1-(3,5-Dichlorophenyl)-3-[(4,6-dihydroxy-5-methyl-2-pyrimidinyl)thio]-2,5-pyrrolidinedione chemical structure, C15H11Cl2N3O4S, CAS 673443-87-3
1-(3,5-Dichlorophenyl)-3-[(4,6-dihydroxy-5-methyl-2-pyrimidinyl)thio]-2,5-pyrrolidinedione
CAS 673443-87-3C15H11Cl2N3O4S
3-[(4,6-Dihydroxy-5-methylpyrimidin-2-yl)sulfanyl]-1-(3,5-dimethylphenyl)pyrrolidine-2,5-dione chemical structure, C17H17N3O4S, CAS 878972-34-0
3-[(4,6-Dihydroxy-5-methylpyrimidin-2-yl)sulfanyl]-1-(3,5-dimethylphenyl)pyrrolidine-2,5-dione
CAS 878972-34-0C17H17N3O4S
3-[(5-Butyl-4,6-dihydroxypyrimidin-2-yl)sulfanyl]-1-(5-chloro-2-methylphenyl)pyrrolidine-2,5-dione chemical structure, C19H20ClN3O4S, CAS 878972-53-3
3-[(5-Butyl-4,6-dihydroxypyrimidin-2-yl)sulfanyl]-1-(5-chloro-2-methylphenyl)pyrrolidine-2,5-dione
CAS 878972-53-3C19H20ClN3O4S
3-[(4,6-Dihydroxy-5-propylpyrimidin-2-yl)sulfanyl]-1-(4-fluorophenyl)pyrrolidine-2,5-dione chemical structure, C17H16FN3O4S, CAS 878972-48-6
3-[(4,6-Dihydroxy-5-propylpyrimidin-2-yl)sulfanyl]-1-(4-fluorophenyl)pyrrolidine-2,5-dione
CAS 878972-48-6C17H16FN3O4S
3-[(4,6-Dihydroxy-5-propylpyrimidin-2-yl)sulfanyl]-1-(4-methylphenyl)pyrrolidine-2,5-dione chemical structure, C18H19N3O4S, CAS 878972-44-2
3-[(4,6-Dihydroxy-5-propylpyrimidin-2-yl)sulfanyl]-1-(4-methylphenyl)pyrrolidine-2,5-dione
CAS 878972-44-2C18H19N3O4S