Murcko scaffold
Ring system with 3 rings and 20 atoms
105 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 20
- Chemicals
- 105
- With full pages
- 14
Scaffold SMILES
O=c1c(C=Nc2ccccc2)c[nH]n1-c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=c1c(C=Nc2ccccc2)c[nH]n1-c1ccccc1](/scaffold/IROPGVCRCRGUQS-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 105 chemicals
4-(p-Acetamidoanilinomethylene)-3-methyl-1-phenyl-2-pyrazolin-5-one
CAS 24664-51-5C19H18N4O2
p-((3-Methyl-5-oxo-1-phenyl-2-pyrazolin-4-ylidene)methylamino)benzoic acid ethyl ester
CAS 24664-52-6C20H19N3O3
![3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-4-[(phenylamino)methylene]- chemical structure, C17H15N3O, CAS 4173-73-3](/s/XIOAQEDPIRQHPA-UHFFFAOYSA-N.svg)
3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-4-[(phenylamino)methylene]-
CAS 4173-73-3C17H15N3O
4-((p-Hydroxyanilino)methylene)-3-methyl-1-phenyl-2-pyrazolin-5-one
CAS 23711-41-3C17H15N3O2
3-Methyl-4-(p-phenetidinomethylene)-1-phenyl-2-pyrazolin-5-one
CAS 23711-48-0C19H19N3O2
4-(p-Anisidinomethylene)-3-methyl-1-phenyl-2-pyrazolin-5-one
CAS 24664-49-1C18H17N3O2
![5-Methyl-4-[(4-nitroanilino)methylene]-2-phenyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C17H14N4O3, CAS 68538-00-1](/s/IVKWMUZROLZERW-UHFFFAOYSA-N.svg)
5-Methyl-4-[(4-nitroanilino)methylene]-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
CAS 68538-00-1C17H14N4O3
(E)-4-(((2,5-Dimethoxyphenyl)amino)methylene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one
CAS 684238-66-2C19H19N3O3
![(4Z)-4-{[(2-Methoxyphenyl)amino]methylidene}-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one chemical structure, C18H17N3O2, CAS 184708-15-4](/s/JFKYBROJTAYMKB-UHFFFAOYSA-N.svg)
(4Z)-4-{[(2-Methoxyphenyl)amino]methylidene}-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one
CAS 184708-15-4C18H17N3O2
![Methyl 2-[(4E)-4-[(4-methylanilino)methylidene]-5-oxo-1-phenylpyrazol-3-yl]acetate chemical structure, C20H19N3O3, CAS 523992-04-3](/s/XHZKAQJSHLOVAV-UHFFFAOYSA-N.svg)
Methyl 2-[(4E)-4-[(4-methylanilino)methylidene]-5-oxo-1-phenylpyrazol-3-yl]acetate
CAS 523992-04-3C20H19N3O3
![(4E)-5-Methyl-4-[(3-nitroanilino)methylidene]-2-phenylpyrazol-3-one chemical structure, C17H14N4O3, CAS 331818-11-2](/s/BWDODWDFWWOTKE-UHFFFAOYSA-N.svg)
(4E)-5-Methyl-4-[(3-nitroanilino)methylidene]-2-phenylpyrazol-3-one
CAS 331818-11-2C17H14N4O3
![(4E)-4-[(4-Fluoroanilino)methylidene]-5-methyl-2-phenylpyrazol-3-one chemical structure, C17H14FN3O, CAS 353248-83-6](/s/IMACFOVUOJRTKU-UHFFFAOYSA-N.svg)
(4E)-4-[(4-Fluoroanilino)methylidene]-5-methyl-2-phenylpyrazol-3-one
CAS 353248-83-6C17H14FN3O
![4-[(2-Chloroanilino)methylene]-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C17H14ClN3O, CAS 330567-90-3](/s/CANGBDFGXRWCOG-UHFFFAOYSA-N.svg)
4-[(2-Chloroanilino)methylene]-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
CAS 330567-90-3C17H14ClN3O
![2-(4-Fluorophenyl)-4-[(4-hydroxyanilino)methylene]-5-methyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C17H14FN3O2, CAS 352702-56-8](/s/LUJUCLZJKCGYDH-UHFFFAOYSA-N.svg)
2-(4-Fluorophenyl)-4-[(4-hydroxyanilino)methylene]-5-methyl-2,4-dihydro-3H-pyrazol-3-one
CAS 352702-56-8C17H14FN3O2
![4-[(2-Hydroxyanilino)methylene]-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C17H15N3O2, CAS 5499-76-3](/s/NKOOKZHTMNFLCJ-UHFFFAOYSA-N.svg)
4-[(2-Hydroxyanilino)methylene]-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
CAS 5499-76-3C17H15N3O2
![(4Z)-4-{[(2,4-Dichlorophenyl)amino]methylidene}-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one chemical structure, C17H13Cl2N3O, CAS 320424-76-8](/s/HLAPMZXEEJQWNW-UHFFFAOYSA-N.svg)
(4Z)-4-{[(2,4-Dichlorophenyl)amino]methylidene}-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one
CAS 320424-76-8C17H13Cl2N3O
![(4Z)-4-{[(4-Chlorophenyl)amino]methylidene}-2-(3,4-dimethylphenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C19H18ClN3O, CAS 5631-52-7](/s/BQQMYWBHXZQZHL-UHFFFAOYSA-N.svg)
(4Z)-4-{[(4-Chlorophenyl)amino]methylidene}-2-(3,4-dimethylphenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one
CAS 5631-52-7C19H18ClN3O
(Z)-4-(((2-Fluorophenyl)amino)methylene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one
CAS 1351583-30-6C17H14FN3O
![(4Z)-4-{[(2,4-Dimethoxyphenyl)amino]methylidene}-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one chemical structure, C19H19N3O3, CAS 320425-02-3](/s/PNGIBWTYDZFNBB-UHFFFAOYSA-N.svg)
(4Z)-4-{[(2,4-Dimethoxyphenyl)amino]methylidene}-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one
CAS 320425-02-3C19H19N3O3
![(4E)-4-{[(3,5-Dichlorophenyl)amino]methylidene}-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C17H13Cl2N3O, CAS 320424-77-9](/s/URGNZMDUWPHLLC-UHFFFAOYSA-N.svg)
(4E)-4-{[(3,5-Dichlorophenyl)amino]methylidene}-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
CAS 320424-77-9C17H13Cl2N3O
![(4Z)-4-{[(2,4-Dichlorophenyl)amino]methylidene}-2-(4-fluorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C17H12Cl2FN3O, CAS 352702-39-7](/s/ILUVQABYCCRKQH-UHFFFAOYSA-N.svg)
(4Z)-4-{[(2,4-Dichlorophenyl)amino]methylidene}-2-(4-fluorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one
CAS 352702-39-7C17H12Cl2FN3O
4-({5-Nitro-2-methoxyanilino}methylene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
CAS 331818-13-4C18H16N4O4
![4-({(E)-[1-(4-Bromophenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]methyl}amino)benzenesulfonamide chemical structure, C17H15BrN4O3S, CAS 4993-18-4](/s/YKSFLCWQAOXUNR-UHFFFAOYSA-N.svg)
4-({(E)-[1-(4-Bromophenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]methyl}amino)benzenesulfonamide
CAS 4993-18-4C17H15BrN4O3S
![(4E)-4-[(3-Bromoanilino)methylidene]-5-methyl-2-phenylpyrazol-3-one chemical structure, C17H14BrN3O, CAS 310455-80-2](/s/PGBXLGWEBYVHAH-UHFFFAOYSA-N.svg)
(4E)-4-[(3-Bromoanilino)methylidene]-5-methyl-2-phenylpyrazol-3-one
CAS 310455-80-2C17H14BrN3O
- Methyl 2-chloro-5-[[(Z)-[3-methyl-1-(4-methylphenyl)-5-oxopyrazol-4-ylidene]methyl]amino]benzoate354994-87-9C20H18ClN3O3
- Methyl 4-[[(Z)-[1-(2,4-dimethylphenyl)-3-methyl-5-oxopyrazol-4-ylidene]methyl]amino]benzoate352681-65-3C21H21N3O3
- Methyl 2-chloro-5-[[(Z)-[1-(2,4-dimethylphenyl)-3-methyl-5-oxopyrazol-4-ylidene]methyl]amino]benzoate352683-90-0C21H20ClN3O3
- 2-(4-Chlorophenyl)-4-[(2,3-dichloroanilino)methylene]-5-methyl-2,4-dihydro-3H-pyrazol-3-one353476-41-2C17H12Cl3N3O
- (4Z)-4-[(3-Bromoanilino)methylidene]-2-(4-fluorophenyl)-5-methylpyrazol-3-one352700-22-2C17H13BrFN3O
- (4E)-4-[(5-Bromo-2-hydroxyanilino)methylidene]-5-methyl-2-phenylpyrazol-3-one312946-11-5C17H14BrN3O2
- 4-[[4-(2-Hydroxyethylsulfonyl)phenyl]iminomethyl]-5-methyl-2-phenyl-1H-pyrazol-3-one5620-51-9C19H19N3O4S
- 4-{[(5-Chloro-2-hydroxyphenyl)amino]methylidene}-2-(3,4-dimethylphenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one310456-09-8C19H18ClN3O2
- (4E)-4-[1-(4-Chloroanilino)ethylidene]-5-methyl-2-(4-nitrophenyl)pyrazol-3-one428826-06-6C18H15ClN4O3
- (4E)-4-[1-(2,5-Dichloroanilino)ethylidene]-5-methyl-2-(4-nitrophenyl)pyrazol-3-one404855-55-6C18H14Cl2N4O3
- Methyl 4-{[(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-yliden)methyl]amino}benzenecarboxylate320424-78-0C19H17N3O3
- (4Z)-5-Methyl-2-phenyl-4-({[2-(trifluoromethyl)phenyl]amino}methylidene)-2,4-dihydro-3H-pyrazol-3-one320424-81-5C18H14F3N3O
- 3-Methyl-1-phenyl-4-(((3-(trifluoromethyl)phenyl)amino)methylene)-2-pyrazolin-5-one320424-82-6C18H14F3N3O
- 2-{[(3-Methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-yliden)methyl]amino}benzenecarbonitrile320424-94-0C18H14N4O
- 4-[(5-Chloro-2-hydroxyanilino)methylene]-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one320425-01-2C17H14ClN3O2
- 4-[(4-Chloroanilino)methylene]-5-ethoxy-2-phenyl-2,4-dihydro-3H-pyrazol-3-one338750-93-9C18H16ClN3O2
- Methyl 4-{[(3-ethoxy-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-yliden)methyl]amino}benzenecarboxylate338750-94-0C20H19N3O4
- 4-[(2,4-Difluoroanilino)methylene]-5-ethoxy-2-phenyl-2,4-dihydro-3H-pyrazol-3-one338750-95-1C18H15F2N3O2
- 4-[(3,5-Dichloroanilino)methylene]-5-ethoxy-2-phenyl-2,4-dihydro-3H-pyrazol-3-one338750-96-2C18H15Cl2N3O2
- 4-(Anilinomethylene)-5-ethoxy-2-phenyl-2,4-dihydro-3H-pyrazol-3-one338750-97-3C18H17N3O2
- 5-Ethoxy-2-phenyl-4-(4-toluidinomethylene)-2,4-dihydro-3H-pyrazol-3-one338750-98-4C19H19N3O2
- 5-Ethoxy-4-[(4-methoxyanilino)methylene]-2-phenyl-2,4-dihydro-3H-pyrazol-3-one338750-99-5C19H19N3O3
- 2-(4-Chlorophenyl)-4-((3,4-dimethylanilino)methylene)-5-ethoxy-2,4-dihydro-3H-pyrazol-3-one338751-05-6C20H20ClN3O2
- 4-[(4-Chloroanilino)methylene]-2-(4-chlorophenyl)-5-ethoxy-2,4-dihydro-3H-pyrazol-3-one338751-06-7C18H15Cl2N3O2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold c1ccc(CSc2nnc(-c3ccccc3)[nH]2)cc1](/scaffold/CBPCFMMAXNCEHC-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2nnc(-c3ccccc3)[nH]2)cc169 chemicals
O=C(Nc1ccccc1)c1ccc(-c2ccccc2)o166 chemicals
O=C1C(N=Nc2ccccc2)C=NN1c1ccccc163 chemicals
O=C(Nc1ccccc1)C1CC(=O)N(c2ccccc2)C149 chemicals
c1ccc(N=Nc2cnn(-c3ccccc3)c2)cc140 chemicals![Scaffold c1ccc(CSc2nnc(-c3ccccn3)[nH]2)cc1](/scaffold/DBVANQGRXKUFCH-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2nnc(-c3ccccn3)[nH]2)cc139 chemicals![Scaffold c1ccc(CSc2nnc(-c3ccncc3)[nH]2)cc1](/scaffold/JTTNDRXETJGQKP-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2nnc(-c3ccncc3)[nH]2)cc135 chemicals
O=C(Nc1nc(-c2ccccc2)cs1)c1ccccc131 chemicals![Scaffold O=c1c(NS(=O)(=O)c2ccccc2)c[nH]n1-c1ccccc1](/scaffold/XHWZVQUKSBVLDH-UHFFFAOYSA-N/structure.svg)
O=c1c(NS(=O)(=O)c2ccccc2)c[nH]n1-c1ccccc130 chemicals![Scaffold O=c1c(N=Cc2ccccc2)c[nH]n1-c1ccccc1](/scaffold/ARHCMYOKQKXAGO-UHFFFAOYSA-N/structure.svg)
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