Murcko scaffold
Ring system with 3 rings and 21 atoms
130 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 21
- Chemicals
- 130
- With full pages
- 5
Scaffold SMILES
O=C(Nc1ccccc1)Nc1nnc(-c2ccccc2)s1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 130 chemicals
![1-(4-Chlorophenyl)-3-[5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]urea chemical structure, C15H10ClFN4OS, CAS 361476-10-0](/s/NUSWELGMOFUJOP-UHFFFAOYSA-N.svg)
1-(4-Chlorophenyl)-3-[5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]urea
CAS 361476-10-0C15H10ClFN4OS
![1-[5-(4-Fluorophenyl)-1,3,4-thiadiazol-2-yl]-3-phenylurea chemical structure, C15H11FN4OS, CAS 5667-30-1](/s/VLTQNTKCWXODKG-UHFFFAOYSA-N.svg)
1-[5-(4-Fluorophenyl)-1,3,4-thiadiazol-2-yl]-3-phenylurea
CAS 5667-30-1C15H11FN4OS
![1-(4-Methoxyphenyl)-3-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]urea chemical structure, C17H16N4O2S, CAS 5560-54-3](/s/GODXSBHEXNJVHX-UHFFFAOYSA-N.svg)
1-(4-Methoxyphenyl)-3-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]urea
CAS 5560-54-3C17H16N4O2S
![1-[5-(4-Fluorophenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)urea chemical structure, C16H13FN4OS, CAS 380595-44-8](/s/ZPPDIZKTDFIVBQ-UHFFFAOYSA-N.svg)
1-[5-(4-Fluorophenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)urea
CAS 380595-44-8C16H13FN4OS
![1-[5-(4-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea chemical structure, C15H10ClFN4OS, CAS 426242-65-1](/s/CSAVECPLRXBCOK-UHFFFAOYSA-N.svg)
1-[5-(4-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea
CAS 426242-65-1C15H10ClFN4OS
![1-[5-(2-Fluorophenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methoxyphenyl)urea chemical structure, C16H13FN4O2S, CAS 356780-25-1](/s/XOVAKUWEDWZNES-UHFFFAOYSA-N.svg)
1-[5-(2-Fluorophenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methoxyphenyl)urea
CAS 356780-25-1C16H13FN4O2S
![1-[5-(3-Fluorophenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)urea chemical structure, C16H13FN4OS, CAS 426245-23-0](/s/HZTFZKOIMVDCLG-UHFFFAOYSA-N.svg)
1-[5-(3-Fluorophenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)urea
CAS 426245-23-0C16H13FN4OS
![1-(2-Fluorophenyl)-3-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]urea chemical structure, C15H10F2N4OS, CAS 426247-55-4](/s/NZXHZLHVFJTBHF-UHFFFAOYSA-N.svg)
1-(2-Fluorophenyl)-3-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]urea
CAS 426247-55-4C15H10F2N4OS
![1-(4-Fluorophenyl)-3-[5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl]urea chemical structure, C16H13FN4OS, CAS 426247-85-0](/s/NAMYRLJWTLAVDO-UHFFFAOYSA-N.svg)
1-(4-Fluorophenyl)-3-[5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl]urea
CAS 426247-85-0C16H13FN4OS
1-(4-Fluorophenyl)-3-(5-phenyl-1,3,4-thiadiazol-2-yl)urea
CAS 426249-47-0C15H11FN4OS
![1-(4-Methylphenyl)-3-[5-(3-methylphenyl)-1,3,4-thiadiazol-2-yl]urea chemical structure, C17H16N4OS, CAS 426250-35-3](/s/IBXLGVSYBWHYGG-UHFFFAOYSA-N.svg)
1-(4-Methylphenyl)-3-[5-(3-methylphenyl)-1,3,4-thiadiazol-2-yl]urea
CAS 426250-35-3C17H16N4OS
1-(4-Ethoxyphenyl)-3-(5-phenyl-1,3,4-thiadiazol-2-yl)urea
CAS 426234-24-4C17H16N4O2S
![1-(4-Fluorophenyl)-3-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]urea chemical structure, C16H13FN4OS, CAS 426241-10-3](/s/VPJJWEIMUGKTIV-UHFFFAOYSA-N.svg)
1-(4-Fluorophenyl)-3-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]urea
CAS 426241-10-3C16H13FN4OS
![1-(2-Fluorophenyl)-3-[5-(2-methoxyphenyl)-1,3,4-thiadiazol-2-yl]urea chemical structure, C16H13FN4O2S, CAS 426242-86-6](/s/KUSQIUJEIFWPTH-UHFFFAOYSA-N.svg)
1-(2-Fluorophenyl)-3-[5-(2-methoxyphenyl)-1,3,4-thiadiazol-2-yl]urea
CAS 426242-86-6C16H13FN4O2S
![1-[5-(3,4-Dimethylphenyl)-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea chemical structure, C17H15FN4OS, CAS 426243-09-6](/s/RKXMCRDTQOLMIZ-UHFFFAOYSA-N.svg)
1-[5-(3,4-Dimethylphenyl)-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea
CAS 426243-09-6C17H15FN4OS
![1-(4-Fluorophenyl)-3-[5-(3-methylphenyl)-1,3,4-thiadiazol-2-yl]urea chemical structure, C16H13FN4OS, CAS 426246-55-1](/s/IBMKBWWKJRYSHK-UHFFFAOYSA-N.svg)
1-(4-Fluorophenyl)-3-[5-(3-methylphenyl)-1,3,4-thiadiazol-2-yl]urea
CAS 426246-55-1C16H13FN4OS
![1-[5-(4-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)urea chemical structure, C16H13ClN4OS, CAS 426252-20-2](/s/IXHYGIGHTKVHLH-UHFFFAOYSA-N.svg)
1-[5-(4-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)urea
CAS 426252-20-2C16H13ClN4OS
![1-[5-(2-Methoxyphenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)urea chemical structure, C17H16N4O2S, CAS 426235-17-8](/s/RPUITAHGYMCKGL-UHFFFAOYSA-N.svg)
1-[5-(2-Methoxyphenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)urea
CAS 426235-17-8C17H16N4O2S
![1-[5-(3-Fluorophenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methoxyphenyl)urea chemical structure, C16H13FN4O2S, CAS 426236-26-2](/s/ZAZSWOGSJIHEBY-UHFFFAOYSA-N.svg)
1-[5-(3-Fluorophenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methoxyphenyl)urea
CAS 426236-26-2C16H13FN4O2S
![1-[5-(2-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea chemical structure, C15H10ClFN4OS, CAS 426241-59-0](/s/HDPCHJLYLDBYIU-UHFFFAOYSA-N.svg)
1-[5-(2-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea
CAS 426241-59-0C15H10ClFN4OS
![1-[5-(3-Methoxyphenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)urea chemical structure, C17H16N4O2S, CAS 426245-13-8](/s/ZSCVLLUIYNXIPR-UHFFFAOYSA-N.svg)
1-[5-(3-Methoxyphenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)urea
CAS 426245-13-8C17H16N4O2S
![1-(4-Fluorophenyl)-3-[5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl]urea chemical structure, C15H10F2N4OS, CAS 426245-72-9](/s/DBXAJSVAVQSLID-UHFFFAOYSA-N.svg)
1-(4-Fluorophenyl)-3-[5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl]urea
CAS 426245-72-9C15H10F2N4OS
![1-(4-Methoxyphenyl)-3-[5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl]urea chemical structure, C17H16N4O2S, CAS 426247-01-0](/s/WSTRJKNJHFIJPP-UHFFFAOYSA-N.svg)
1-(4-Methoxyphenyl)-3-[5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl]urea
CAS 426247-01-0C17H16N4O2S
![1-(4-Fluorophenyl)-3-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]urea chemical structure, C15H10F2N4OS, CAS 426250-91-1](/s/JNPIHKJJIDGCPJ-UHFFFAOYSA-N.svg)
1-(4-Fluorophenyl)-3-[5-(4-fluorophenyl)-1,3,4-thiadiazol-2-yl]urea
CAS 426250-91-1C15H10F2N4OS
- 1-(4-Methylphenyl)-3-[5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl]urea426252-03-1C17H16N4OS
- 1-(4-Fluorophenyl)-3-[5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]urea428480-26-6C15H10F2N4OS
- 1-(4-Fluorophenyl)-3-[5-(2-methoxyphenyl)-1,3,4-thiadiazol-2-yl]urea428480-30-2C16H13FN4O2S
- 1-[5-(3,4-Dimethylphenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)urea428481-57-6C18H18N4OS
- 1-(3,4-Dimethylphenyl)-3-[5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl]urea429624-61-3C17H15FN4OS
- 1-(3,4-Dimethylphenyl)-3-[5-(3-methylphenyl)-1,3,4-thiadiazol-2-yl]urea429627-19-0C18H18N4OS
- 1-(3,4-Dimethylphenyl)-3-[5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]urea429629-57-2C17H15FN4OS
- 1-(3,4-Dimethylphenyl)-3-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]urea429628-52-4C18H18N4OS
- 1-(3,4-Dimethylphenyl)-3-[5-(2-methylphenyl)-1,3,4-thiadiazol-2-yl]urea429628-79-5C18H18N4OS
- 1-(4-Fluorophenyl)-3-[5-(3-methoxyphenyl)-1,3,4-thiadiazol-2-yl]urea426235-76-9C16H13FN4O2S
- 1-[5-(2-Fluorophenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)urea356780-03-5C16H13FN4OS
- 1-[5-(3,4-Dimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea426246-76-6C17H15FN4O3S
- 1-(4-Methoxyphenyl)-3-[5-(2-methoxyphenyl)-1,3,4-thiadiazol-2-yl]urea426246-88-0C17H16N4O3S
- 1-[5-(4-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-1-ethyl-3-(4-methoxyphenyl)urea489422-87-9C18H17ClN4O2S
- 3-(4-Chlorophenyl)-1-ethyl-1-(5-phenyl-1,3,4-thiadiazol-2-yl)urea448914-61-2C17H15ClN4OS
- 1-(4-Methoxyphenyl)-3-[5-(3-methoxyphenyl)-1,3,4-thiadiazol-2-yl]urea426251-90-3C17H16N4O3S
- 1-[5-(4-Ethoxyphenyl)-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea426234-87-9C17H15FN4O2S
- 1-[5-(3-Ethoxyphenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methoxyphenyl)urea426236-16-0C18H18N4O3S
- 1-(4-Ethoxyphenyl)-3-[5-(3-methylphenyl)-1,3,4-thiadiazol-2-yl]urea426236-40-0C18H18N4O2S
- 1-(2,4-Dichlorophenyl)-3-[5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl]urea6372-24-3C15H9Cl2N5O3S
- 1-[5-(4-Chlorophenyl)-1,3,4-thiadiazol-2-yl]-3-(4-ethoxyphenyl)urea426239-16-9C17H15ClN4O2S
- 1-[5-(2-Iodophenyl)-1,3,4-thiadiazol-2-yl]-3-(3-methoxyphenyl)urea6372-47-0C16H13IN4O2S
- 1-[5-(3-Ethoxyphenyl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)urea426240-46-2C18H18N4O2S
- 1-[5-(3,4-Dichlorophenyl)-1,3,4-thiadiazol-2-yl]-3-(2-fluorophenyl)urea6372-79-8C15H9Cl2FN4OS
Related scaffolds
Same ring framework with different atoms or bond orders
O=C1CC(NCCc2ccccc2)C(=O)N1c1ccccc130 chemicals
O=C(CSc1nnc(-c2ccccc2)o1)N1CCCCC127 chemicals
O=C(C=Cc1ccc(-c2ccccc2)o1)c1ccccc117 chemicals
O=C(Cc1ccccc1)Nc1nc(-c2ccccc2)cs115 chemicals
O=C(CSc1nnc(-c2ccccc2)o1)N1CCOCC113 chemicals
O=S(=O)(NCc1cc(-c2ccccc2)no1)c1ccccc113 chemicals
C(=NNc1nc(-c2ccccc2)cs1)c1ccccc112 chemicals
O=S(=O)(NCc1nc(-c2ccccc2)no1)c1ccccc111 chemicals![Scaffold O=C(Nc1ccccc1)Nc1c[nH]n(-c2ccccc2)c1=O](/scaffold/QSSZUVFMHJMXDP-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)Nc1c[nH]n(-c2ccccc2)c1=O11 chemicals
O=C(Cc1ccccc1)Nc1nnc(-c2ccccc2)o111 chemicals![Scaffold O=C(CSc1nnc(-c2ccccc2)[nH]1)c1ccccc1](/scaffold/DLNCASBDPGAELF-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(-c2ccccc2)[nH]1)c1ccccc110 chemicals
O=c1n(-c2ccccc2)cnn1CCOc1ccccc110 chemicals