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Murcko scaffold

Ring system with 3 rings and 19 atoms

23 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
23
With full pages
4
Scaffold SMILES

O=C1N=C(c2ccccc2)SC1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1N=C(c2ccccc2)SC1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

5-(3-Chloro-4-hydroxy-5-methoxybenzylidene)-2-phenyl-1,3-thiazol-4(5H)-one chemical structure, C17H12ClNO3S, CAS 352690-86-9
5-(3-Chloro-4-hydroxy-5-methoxybenzylidene)-2-phenyl-1,3-thiazol-4(5H)-one
CAS 352690-86-9C17H12ClNO3S
5-(4-Ethoxy-3-methylbenzylidene)-2-phenyl-1,3-thiazol-4(5H)-one chemical structure, C19H17NO2S, CAS 353786-88-6
5-(4-Ethoxy-3-methylbenzylidene)-2-phenyl-1,3-thiazol-4(5H)-one
CAS 353786-88-6C19H17NO2S
(5z)-5-Benzylidene-2-phenyl-1,3-thiazol-4(5H)-one chemical structure, C16H11NOS, CAS 5258-08-2
(5z)-5-Benzylidene-2-phenyl-1,3-thiazol-4(5H)-one
CAS 5258-08-2C16H11NOS
5-[(4-Methoxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one chemical structure, C18H15NO2S
5-[(4-Methoxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one
C18H15NO2S
5-(3,4-Dimethylbenzylidene)-2-phenyl-1,3-thiazol-4(5H)-one chemical structure, C18H15NOS, CAS 355002-60-7
5-(3,4-Dimethylbenzylidene)-2-phenyl-1,3-thiazol-4(5H)-one
CAS 355002-60-7C18H15NOS
(5Z)-5-[(3-Bromo-5-ethoxy-4-hydroxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one chemical structure, C19H16BrNO3S, CAS 328272-00-0
(5Z)-5-[(3-Bromo-5-ethoxy-4-hydroxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one
CAS 328272-00-0C19H16BrNO3S
(5Z)-5-[(3-Bromo-4,5-diethoxyphenyl)methylidene]-2-phenyl-1,3-thiazol-4-one chemical structure, C20H18BrNO3S, CAS 355003-28-0
(5Z)-5-[(3-Bromo-4,5-diethoxyphenyl)methylidene]-2-phenyl-1,3-thiazol-4-one
CAS 355003-28-0C20H18BrNO3S
(5Z)-5-[(3-Chloro-5-ethoxy-4-hydroxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one chemical structure, C19H16ClNO3S, CAS 353478-49-6
(5Z)-5-[(3-Chloro-5-ethoxy-4-hydroxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one
CAS 353478-49-6C19H16ClNO3S
5-(3-Bromo-4-hydroxy-5-methoxybenzylidene)-2-phenyl-1,3-thiazol-4(5H)-one chemical structure, C17H12BrNO3S, CAS 5624-90-8
5-(3-Bromo-4-hydroxy-5-methoxybenzylidene)-2-phenyl-1,3-thiazol-4(5H)-one
CAS 5624-90-8C17H12BrNO3S
(5Z)-5-[(5-Chloro-2-hydroxy-3-methoxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one chemical structure, C18H14ClNO3S, CAS 353476-80-9
(5Z)-5-[(5-Chloro-2-hydroxy-3-methoxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one
CAS 353476-80-9C18H14ClNO3S
(5Z)-5-[(3-Chloro-4-hydroxy-5-methoxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one chemical structure, C18H14ClNO3S, CAS 353478-85-0
(5Z)-5-[(3-Chloro-4-hydroxy-5-methoxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one
CAS 353478-85-0C18H14ClNO3S
5-(3-Bromo-2-hydroxy-5-methoxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one chemical structure, C18H14BrNO3S, CAS 353790-56-4
5-(3-Bromo-2-hydroxy-5-methoxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one
CAS 353790-56-4C18H14BrNO3S
(5Z)-5-[(2-Bromo-5-ethoxy-4-methoxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one chemical structure, C20H18BrNO3S, CAS 355001-82-0
(5Z)-5-[(2-Bromo-5-ethoxy-4-methoxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one
CAS 355001-82-0C20H18BrNO3S
2-(4-Methylphenyl)-5-(2,3,4-trimethoxybenzylidene)-1,3-thiazol-4(5H)-one chemical structure, C20H19NO4S, CAS 354544-85-7
2-(4-Methylphenyl)-5-(2,3,4-trimethoxybenzylidene)-1,3-thiazol-4(5H)-one
CAS 354544-85-7C20H19NO4S
5-(2,3-Dibromo-6-hydroxy-5-methoxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one chemical structure, C18H13Br2NO3S, CAS 444938-08-3
5-(2,3-Dibromo-6-hydroxy-5-methoxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one
CAS 444938-08-3C18H13Br2NO3S
(5Z)-5-[(5-Bromo-2-hydroxy-3-methoxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one chemical structure, C18H14BrNO3S, CAS 352686-23-8
(5Z)-5-[(5-Bromo-2-hydroxy-3-methoxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one
CAS 352686-23-8C18H14BrNO3S
(Z)-Methyl 4-((4-oxo-2-(p-tolyl)thiazol-5(4H)-ylidene)methyl)benzoate chemical structure, C19H15NO3S, CAS 1637449-08-1
(Z)-Methyl 4-((4-oxo-2-(p-tolyl)thiazol-5(4H)-ylidene)methyl)benzoate
CAS 1637449-08-1C19H15NO3S
5-(4-Hydroxy-3-methoxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one chemical structure, C18H15NO3S, CAS 5622-85-5
5-(4-Hydroxy-3-methoxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one
CAS 5622-85-5C18H15NO3S
(5Z)-5-[(4-Hydroxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one chemical structure, C17H13NO2S, CAS 1637449-06-9
(5Z)-5-[(4-Hydroxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one
CAS 1637449-06-9C17H13NO2S
(z)-5-(4-Methoxybenzylidene)-2-(p-tolyl)thiazol-4(5H)-one chemical structure, C18H15NO2S, CAS 1125863-43-5
(z)-5-(4-Methoxybenzylidene)-2-(p-tolyl)thiazol-4(5H)-one
CAS 1125863-43-5C18H15NO2S
(5E)-5-[(4-Methoxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one chemical structure, C18H15NO2S
(5E)-5-[(4-Methoxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one
C18H15NO2S
(5Z)-5-(4-Methoxybenzylidene)-2-phenyl-1,3-thiazol-4(5H)-one chemical structure, C17H13NO2S, CAS 1272519-91-1
(5Z)-5-(4-Methoxybenzylidene)-2-phenyl-1,3-thiazol-4(5H)-one
CAS 1272519-91-1C17H13NO2S
(Z)-2-(4-Chlorophenyl)-5-(4-methoxybenzylidene)-5H-thiazol-4-one chemical structure, C17H12ClNO2S, CAS 1272519-89-7
(Z)-2-(4-Chlorophenyl)-5-(4-methoxybenzylidene)-5H-thiazol-4-one
CAS 1272519-89-7C17H12ClNO2S