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Murcko scaffold

Ring system with 3 rings and 22 atoms

8 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
8
With full pages
5
Scaffold SMILES

O=C(ON=Cc1cnc(-c2ccccc2)s1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(ON=Cc1cnc(-c2ccccc2)s1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

4-Methyl-5-{[(3-methylbenzoyl)oxy]ethanimidoyl}-2-phenyl-1,3-thiazole chemical structure, C20H18N2O2S, CAS 860649-88-3
4-Methyl-5-{[(3-methylbenzoyl)oxy]ethanimidoyl}-2-phenyl-1,3-thiazole
CAS 860649-88-3C20H18N2O2S
4-Methyl-2-phenyl-5-({[3-(trifluoromethyl)benzoyl]oxy}ethanimidoyl)-1,3-thiazole chemical structure, C20H15F3N2O2S, CAS 477858-05-2
4-Methyl-2-phenyl-5-({[3-(trifluoromethyl)benzoyl]oxy}ethanimidoyl)-1,3-thiazole
CAS 477858-05-2C20H15F3N2O2S
5-{[(4-Fluorobenzoyl)oxy]ethanimidoyl}-4-methyl-2-phenyl-1,3-thiazole chemical structure, C19H15FN2O2S, CAS 477858-06-3
5-{[(4-Fluorobenzoyl)oxy]ethanimidoyl}-4-methyl-2-phenyl-1,3-thiazole
CAS 477858-06-3C19H15FN2O2S
(E)-[1-(4-Methyl-2-phenyl-1,3-thiazol-5-yl)ethylidene]amino 3,4-dichlorobenzoate chemical structure, C19H14Cl2N2O2S, CAS 477858-07-4
(E)-[1-(4-Methyl-2-phenyl-1,3-thiazol-5-yl)ethylidene]amino 3,4-dichlorobenzoate
CAS 477858-07-4C19H14Cl2N2O2S
5-{[(4-Chlorobenzoyl)oxy]ethanimidoyl}-4-methyl-2-phenyl-1,3-thiazole chemical structure, C19H15ClN2O2S, CAS 477858-08-5
5-{[(4-Chlorobenzoyl)oxy]ethanimidoyl}-4-methyl-2-phenyl-1,3-thiazole
CAS 477858-08-5C19H15ClN2O2S
2-(4-Chlorophenyl)-5-{[(4-fluorobenzoyl)oxy]ethanimidoyl}-4-methyl-1,3-thiazole chemical structure, C19H14ClFN2O2S, CAS 477872-46-1
2-(4-Chlorophenyl)-5-{[(4-fluorobenzoyl)oxy]ethanimidoyl}-4-methyl-1,3-thiazole
CAS 477872-46-1C19H14ClFN2O2S
5-{[(4-Chlorobenzoyl)oxy]ethanimidoyl}-2-(4-chlorophenyl)-4-methyl-1,3-thiazole chemical structure, C19H14Cl2N2O2S, CAS 860788-25-6
5-{[(4-Chlorobenzoyl)oxy]ethanimidoyl}-2-(4-chlorophenyl)-4-methyl-1,3-thiazole
CAS 860788-25-6C19H14Cl2N2O2S
2-(4-Chlorophenyl)-4-methyl-5-{[(4-methylbenzoyl)oxy]ethanimidoyl}-1,3-thiazole chemical structure, C20H17ClN2O2S, CAS 477872-47-2
2-(4-Chlorophenyl)-4-methyl-5-{[(4-methylbenzoyl)oxy]ethanimidoyl}-1,3-thiazole
CAS 477872-47-2C20H17ClN2O2S