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Murcko scaffold

4-Phenyl-2-(1H-pyrazol-1-yl)-1,3-thiazole scaffold

148 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
148
With full pages
16
Scaffold SMILES

c1ccc(-c2csc(-n3cccn3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Phenyl-2-(1H-pyrazol-1-yl)-1,3-thiazole page
Murcko scaffold c1ccc(-c2csc(-n3cccn3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 148 chemicals

4-(4-Bromophenyl)-2-[5-(trifluoromethyl)-1H-pyrazol-1-yl]-1,3-thiazole chemical structure, C13H7BrF3N3S, CAS 956624-44-5
4-(4-Bromophenyl)-2-[5-(trifluoromethyl)-1H-pyrazol-1-yl]-1,3-thiazole
CAS 956624-44-5C13H7BrF3N3S
Ethyl 1-[4-(4-chlorophenyl)-2-thiazolyl]-4-(trifluoromethyl)-1H-pyrazole-3-carboxylate chemical structure, C16H11ClF3N3O2S, CAS 959581-04-5
Ethyl 1-[4-(4-chlorophenyl)-2-thiazolyl]-4-(trifluoromethyl)-1H-pyrazole-3-carboxylate
CAS 959581-04-5C16H11ClF3N3O2S
2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4-(3-nitrophenyl)-1,3-thiazole chemical structure, C14H12N4O2S, CAS 956741-77-8
2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4-(3-nitrophenyl)-1,3-thiazole
CAS 956741-77-8C14H12N4O2S
1-(4-Phenyl-1,3-thiazol-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid chemical structure, C14H8F3N3O2S, CAS 159885-80-0
1-(4-Phenyl-1,3-thiazol-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
CAS 159885-80-0C14H8F3N3O2S
Pyrocatechol, 4-(2-(3,5-dimethyl-1-pyrazolyl)-4-thiazolyl)- chemical structure, C14H13N3O2S, CAS 75007-31-7
Pyrocatechol, 4-(2-(3,5-dimethyl-1-pyrazolyl)-4-thiazolyl)-
CAS 75007-31-7C14H13N3O2S
Pyrocatechol, 4-(2-(3-methyl-5-(1,1,2,2-tetrafluoroethyl)-1-pyrazolyl)-4-thiazolyl)- chemical structure, C15H11F4N3O2S, CAS 75013-45-5
Pyrocatechol, 4-(2-(3-methyl-5-(1,1,2,2-tetrafluoroethyl)-1-pyrazolyl)-4-thiazolyl)-
CAS 75013-45-5C15H11F4N3O2S
4-(3,4-Dichlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-1,3-thiazole chemical structure, C14H11Cl2N3S, CAS 477762-46-2
4-(3,4-Dichlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-1,3-thiazole
CAS 477762-46-2C14H11Cl2N3S
1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-N-prop-2-enyl-5-(trifluoromethyl)pyrazole-4-carboxamide chemical structure, C17H12ClF3N4OS, CAS 321998-56-5
1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-N-prop-2-enyl-5-(trifluoromethyl)pyrazole-4-carboxamide
CAS 321998-56-5C17H12ClF3N4OS
5-Bromo-2-(4-bromo-3,5-dimethyl-1H-pyrazol-1-yl)-4-(3,4-dichlorophenyl)-1,3-thiazole chemical structure, C14H9Br2Cl2N3S, CAS 477762-47-3
5-Bromo-2-(4-bromo-3,5-dimethyl-1H-pyrazol-1-yl)-4-(3,4-dichlorophenyl)-1,3-thiazole
CAS 477762-47-3C14H9Br2Cl2N3S
2-[3-Methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole chemical structure, C14H10F3N3S, CAS 141177-76-6
2-[3-Methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole
CAS 141177-76-6C14H10F3N3S
5-Chloro-2-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-4-(3,4-dichlorophenyl)-1,3-thiazole chemical structure, C14H9Cl4N3S, CAS 956357-06-5
5-Chloro-2-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-4-(3,4-dichlorophenyl)-1,3-thiazole
CAS 956357-06-5C14H9Cl4N3S
N-Allyl-1-(4-phenyl-1,3-thiazol-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide chemical structure, C17H13F3N4OS, CAS 321998-59-8
N-Allyl-1-(4-phenyl-1,3-thiazol-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide
CAS 321998-59-8C17H13F3N4OS
Methyl 5-amino-1-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazole-4-carboxylate chemical structure, C14H12N4O2S, CAS 956738-04-8
Methyl 5-amino-1-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazole-4-carboxylate
CAS 956738-04-8C14H12N4O2S
5-Chloro-2-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-4-(4-chlorophenyl)-1,3-thiazole chemical structure, C14H10Cl3N3S, CAS 956187-27-2
5-Chloro-2-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-4-(4-chlorophenyl)-1,3-thiazole
CAS 956187-27-2C14H10Cl3N3S
4-(tert-Butylsulfonyl)-1-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazol-5-ylamine chemical structure, C16H18N4O2S2, CAS 956796-04-6
4-(tert-Butylsulfonyl)-1-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazol-5-ylamine
CAS 956796-04-6C16H18N4O2S2
Ethyl 5-amino-1-[4-(4-methylphenyl)-1,3-thiazol-2-yl]pyrazole-4-carboxylate chemical structure, C16H16N4O2S, CAS 957045-17-9
Ethyl 5-amino-1-[4-(4-methylphenyl)-1,3-thiazol-2-yl]pyrazole-4-carboxylate
CAS 957045-17-9C16H16N4O2S
5-Chloro-2-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-4-(4-fluorophenyl)-1,3-thiazole chemical structure, C14H10Cl2FN3S, CAS 956705-89-8
5-Chloro-2-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-4-(4-fluorophenyl)-1,3-thiazole
CAS 956705-89-8C14H10Cl2FN3S
1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-N-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide chemical structure, C15H10ClF3N4OS, CAS 321574-51-0
1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-N-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide
CAS 321574-51-0C15H10ClF3N4OS
N-(3-Hydroxypropyl)-5-methyl-1-(4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)-1H-pyrazole-4-carboxamide chemical structure, C18H17F3N4O2S, CAS 162112-37-0
N-(3-Hydroxypropyl)-5-methyl-1-(4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)-1H-pyrazole-4-carboxamide
CAS 162112-37-0C18H17F3N4O2S
5-Methyl-1-[4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]pyrazole-4-carboxylic acid chemical structure, C15H10F3N3O2S, CAS 159885-85-5
5-Methyl-1-[4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]pyrazole-4-carboxylic acid
CAS 159885-85-5C15H10F3N3O2S
3-[2-(3,5-Dimethyl-1H-pyrazol-1-yl)-1,3-thiazol-4-yl]phenyl acetate chemical structure, C16H15N3O2S, CAS 1171379-26-2
3-[2-(3,5-Dimethyl-1H-pyrazol-1-yl)-1,3-thiazol-4-yl]phenyl acetate
CAS 1171379-26-2C16H15N3O2S
Methyl 1-[4-(4-methoxyphenyl)-2-thiazolyl]-5-methyl-1H-pyrazole-3-carboxylate chemical structure, C16H15N3O3S, CAS 1015856-20-8
Methyl 1-[4-(4-methoxyphenyl)-2-thiazolyl]-5-methyl-1H-pyrazole-3-carboxylate
CAS 1015856-20-8C16H15N3O3S
1-[4-(2,4-Dichlorophenyl)-1,3-thiazol-2-yl]-3-methyl-1H-pyrazole-5-carboxylic acid chemical structure, C14H9Cl2N3O2S, CAS 1172936-72-9
1-[4-(2,4-Dichlorophenyl)-1,3-thiazol-2-yl]-3-methyl-1H-pyrazole-5-carboxylic acid
CAS 1172936-72-9C14H9Cl2N3O2S
N-[3-Methyl-1-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazol-5-yl]acetamide chemical structure, C15H14N4OS, CAS 1020487-97-1
N-[3-Methyl-1-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazol-5-yl]acetamide
CAS 1020487-97-1C15H14N4OS