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Murcko scaffold

Ring system with 3 rings and 18 atoms

179 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
179
With full pages
36
Scaffold SMILES

c1ccc(Cn2ccc(-c3ccccc3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Cn2ccc(-c3ccccc3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 97 to 144 of 179 chemicals

1-(4-Methoxybenzyl)-3-phenyl-1H-pyrazole-4-carbaldehyde chemical structure, C18H16N2O2, CAS 187344-11-2
1-(4-Methoxybenzyl)-3-phenyl-1H-pyrazole-4-carbaldehyde
CAS 187344-11-2C18H16N2O2
3-(2-Chlorophenyl)-1-[(2-methylphenyl)methyl]-1H-pyrazol-5-amine chemical structure, C17H16ClN3, CAS 1486433-09-3
3-(2-Chlorophenyl)-1-[(2-methylphenyl)methyl]-1H-pyrazol-5-amine
CAS 1486433-09-3C17H16ClN3
Methyl 1-(4-methoxybenzyl)-3-phenyl-1H-pyrazole-5-carboxylate chemical structure, C19H18N2O3, CAS 187344-21-4
Methyl 1-(4-methoxybenzyl)-3-phenyl-1H-pyrazole-5-carboxylate
CAS 187344-21-4C19H18N2O3
2-Benzyl-5-(2,4-dimethylphenyl)pyrazole-3-carboxylic acid chemical structure, C19H18N2O2, CAS 1354408-22-2
2-Benzyl-5-(2,4-dimethylphenyl)pyrazole-3-carboxylic acid
CAS 1354408-22-2C19H18N2O2
4-Bromo-1-{[4-(methyloxy)phenyl]methyl}-3-(4-nitrophenyl)-1H-pyrazole chemical structure, C17H14BrN3O3, CAS 942920-24-3
4-Bromo-1-{[4-(methyloxy)phenyl]methyl}-3-(4-nitrophenyl)-1H-pyrazole
CAS 942920-24-3C17H14BrN3O3
(S)-Ethyl 4-(1-(3-(3,5-dichlorophenyl)-5-(trifluoromethylsulfonyloxy)-1H-pyrazol-1-yl)ethyl)benzoate chemical structure, C21H17Cl2F3N2O5S, CAS 870823-09-9
(S)-Ethyl 4-(1-(3-(3,5-dichlorophenyl)-5-(trifluoromethylsulfonyloxy)-1H-pyrazol-1-yl)ethyl)benzoate
CAS 870823-09-9C21H17Cl2F3N2O5S
Nrf2-IN-1 chemical structure, C21H22ClN3O2, CAS 1610022-76-8
Nrf2-IN-1
CAS 1610022-76-8C21H22ClN3O2
Methyl 1-benzyl-3-phenyl-1H-pyrazole-5-carboxylate chemical structure, C18H16N2O2, CAS 1202029-59-1
Methyl 1-benzyl-3-phenyl-1H-pyrazole-5-carboxylate
CAS 1202029-59-1C18H16N2O2
1-Benzyl-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid chemical structure, C17H13FN2O2, CAS 1020239-54-6
1-Benzyl-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid
CAS 1020239-54-6C17H13FN2O2
Ethyl 1-benzyl-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylate chemical structure, C19H17FN2O2, CAS 1020239-47-7
Ethyl 1-benzyl-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylate
CAS 1020239-47-7C19H17FN2O2
1-Benzyl-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid chemical structure, C17H13ClN2O2, CAS 1020239-10-4
1-Benzyl-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid
CAS 1020239-10-4C17H13ClN2O2
Methyl 1-benzyl-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylate chemical structure, C18H15ClN2O2, CAS 1202030-53-2
Methyl 1-benzyl-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylate
CAS 1202030-53-2C18H15ClN2O2
1-[(2,4-Dichlorophenyl)methyl]-3-phenyl-1H-pyrazole-5-carboxylic acid chemical structure, C17H12Cl2N2O2, CAS 1020238-84-9
1-[(2,4-Dichlorophenyl)methyl]-3-phenyl-1H-pyrazole-5-carboxylic acid
CAS 1020238-84-9C17H12Cl2N2O2
1-(2,5-Dichlorobenzyl)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide chemical structure, C17H13Cl3N4O, CAS 1020239-22-8
1-(2,5-Dichlorobenzyl)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide
CAS 1020239-22-8C17H13Cl3N4O
1-(2,5-Dichlorobenzyl)-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid chemical structure, C17H11Cl3N2O2, CAS 1020239-15-9
1-(2,5-Dichlorobenzyl)-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid
CAS 1020239-15-9C17H11Cl3N2O2
1-(2,5-Dichlorobenzyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid chemical structure, C17H11Cl2FN2O2, CAS 1020239-60-4
1-(2,5-Dichlorobenzyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid
CAS 1020239-60-4C17H11Cl2FN2O2
1-(2,5-Dichlorobenzyl)-3-phenyl-1H-pyrazole-5-carbohydrazide chemical structure, C17H14Cl2N4O, CAS 1020238-91-8
1-(2,5-Dichlorobenzyl)-3-phenyl-1H-pyrazole-5-carbohydrazide
CAS 1020238-91-8C17H14Cl2N4O
1-(2,5-Dichlorobenzyl)-3-phenyl-1H-pyrazole-5-carboxylic acid chemical structure, C17H12Cl2N2O2, CAS 1020238-85-0
1-(2,5-Dichlorobenzyl)-3-phenyl-1H-pyrazole-5-carboxylic acid
CAS 1020238-85-0C17H12Cl2N2O2
1-(2,5-Dichlorobenzyl)-3-p-tolyl-1H-pyrazole-5-carboxylic acid chemical structure, C18H14Cl2N2O2, CAS 1020239-04-6
1-(2,5-Dichlorobenzyl)-3-p-tolyl-1H-pyrazole-5-carboxylic acid
CAS 1020239-04-6C18H14Cl2N2O2
1-(4-Chlorobenzyl)-3-(4-bromophenyl)-1H-pyrazole-5-carbohydrazide chemical structure, C17H14BrClN4O, CAS 1020239-41-1
1-(4-Chlorobenzyl)-3-(4-bromophenyl)-1H-pyrazole-5-carbohydrazide
CAS 1020239-41-1C17H14BrClN4O
1-(4-Chlorobenzyl)-3-(4-bromophenyl)-1H-pyrazole-5-carboxylic acid chemical structure, C17H12BrClN2O2, CAS 1020239-33-1
1-(4-Chlorobenzyl)-3-(4-bromophenyl)-1H-pyrazole-5-carboxylic acid
CAS 1020239-33-1C17H12BrClN2O2
1-(4-Chlorobenzyl)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide chemical structure, C17H14Cl2N4O, CAS 1020239-18-2
1-(4-Chlorobenzyl)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide
CAS 1020239-18-2C17H14Cl2N4O
1-(4-Chlorobenzyl)-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid chemical structure, C17H12Cl2N2O2, CAS 1020239-12-6
1-(4-Chlorobenzyl)-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid
CAS 1020239-12-6C17H12Cl2N2O2
1-(4-Chlorobenzyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid chemical structure, C17H12ClFN2O2, CAS 1020239-56-8
1-(4-Chlorobenzyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxylic acid
CAS 1020239-56-8C17H12ClFN2O2