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Murcko scaffold

Ring system with 3 rings and 22 atoms

42 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
42
With full pages
5
Scaffold SMILES

O=C(C=Cc1ccccc1)c1ccc(-c2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)c1ccc(-c2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 42 of 42 chemicals

2-Propen-1-one, 1-[1,1'-biphenyl]-4-yl-3-(3,4-dimethoxyphenyl)- chemical structure, C23H20O3, CAS 36635-79-7
2-Propen-1-one, 1-[1,1'-biphenyl]-4-yl-3-(3,4-dimethoxyphenyl)-
CAS 36635-79-7C23H20O3
3-(3-Bromophenyl)-1-(4-phenylphenyl)prop-2-en-1-one chemical structure, C21H15BrO, CAS 77153-28-7
3-(3-Bromophenyl)-1-(4-phenylphenyl)prop-2-en-1-one
CAS 77153-28-7C21H15BrO
4-[3-Oxo-3-(4-phenylphenyl)prop-1-enyl]benzonitrile chemical structure, C22H15NO, CAS 62584-62-7
4-[3-Oxo-3-(4-phenylphenyl)prop-1-enyl]benzonitrile
CAS 62584-62-7C22H15NO
3-(2-Chlorophenyl)-1-(4-phenylphenyl)prop-2-en-1-one chemical structure, C21H15ClO, CAS 13650-77-6
3-(2-Chlorophenyl)-1-(4-phenylphenyl)prop-2-en-1-one
CAS 13650-77-6C21H15ClO
(2E)-3-(2-Methoxyphenyl)-1-(4-phenylphenyl)prop-2-en-1-one chemical structure, C22H18O2, CAS 1539275-18-7
(2E)-3-(2-Methoxyphenyl)-1-(4-phenylphenyl)prop-2-en-1-one
CAS 1539275-18-7C22H18O2
(E)-3-(4-Nitrophenyl)-1-(4-phenylphenyl)prop-2-en-1-one chemical structure, C21H15NO3, CAS 132434-49-2
(E)-3-(4-Nitrophenyl)-1-(4-phenylphenyl)prop-2-en-1-one
CAS 132434-49-2C21H15NO3
1-(1,1'-Biphenyl)-4-YL-3-phenyl-2-propen-1-one chemical structure, C21H16O, CAS 81878-54-8
1-(1,1'-Biphenyl)-4-YL-3-phenyl-2-propen-1-one
CAS 81878-54-8C21H16O
(2E)-3-(3-Nitrophenyl)-1-(4-phenylphenyl)prop-2-en-1-one chemical structure, C21H15NO3, CAS 1042167-64-5
(2E)-3-(3-Nitrophenyl)-1-(4-phenylphenyl)prop-2-en-1-one
CAS 1042167-64-5C21H15NO3
(E)-3-(3,4-Dimethoxyphenyl)-1-(4-phenylphenyl)prop-2-en-1-one chemical structure, C23H20O3, CAS 1629233-18-6
(E)-3-(3,4-Dimethoxyphenyl)-1-(4-phenylphenyl)prop-2-en-1-one
CAS 1629233-18-6C23H20O3
Chalcone, 3-chloro-4'-phenyl- chemical structure, C21H15ClO, CAS 13662-61-8
Chalcone, 3-chloro-4'-phenyl-
CAS 13662-61-8C21H15ClO
(2E)-1-(1,1'-Biphenyl)-4-yl-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one chemical structure, C24H22O4, CAS 1404477-11-7
(2E)-1-(1,1'-Biphenyl)-4-yl-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one
CAS 1404477-11-7C24H22O4
1-(4-Biphenylyl)-3-(4-ethoxyphenyl)-2-propen-1-one chemical structure, C23H20O2, CAS 1164475-39-1
1-(4-Biphenylyl)-3-(4-ethoxyphenyl)-2-propen-1-one
CAS 1164475-39-1C23H20O2
4-Chloro-4'-phenylchalcone chemical structure, C21H15ClO, CAS 13662-60-7
4-Chloro-4'-phenylchalcone
CAS 13662-60-7C21H15ClO
(E)-3-(2-Methylphenyl)-1-(4-phenylphenyl)prop-2-en-1-one chemical structure, C22H18O, CAS 1637208-52-6
(E)-3-(2-Methylphenyl)-1-(4-phenylphenyl)prop-2-en-1-one
CAS 1637208-52-6C22H18O
(E)-2-Methyl-3-phenyl-1-(4-phenylphenyl)prop-2-en-1-one chemical structure, C22H18O, CAS 14436-08-9
(E)-2-Methyl-3-phenyl-1-(4-phenylphenyl)prop-2-en-1-one
CAS 14436-08-9C22H18O
(2E)-3-(3-Fluorophenyl)-1-(4-phenylphenyl)prop-2-en-1-one chemical structure, C21H15FO, CAS 109790-55-8
(2E)-3-(3-Fluorophenyl)-1-(4-phenylphenyl)prop-2-en-1-one
CAS 109790-55-8C21H15FO
1-(4'-(Hydroxy(oxido)amino)(1,1'-biphenyl)-4-yl)-3-phenyl-2-propen-1-one chemical structure, C21H15NO3, CAS 7402-87-1
1-(4'-(Hydroxy(oxido)amino)(1,1'-biphenyl)-4-yl)-3-phenyl-2-propen-1-one
CAS 7402-87-1C21H15NO3
Biphenyl-4-yl(m-methylstyryl) ketone chemical structure, C22H18O, CAS 13662-57-2
Biphenyl-4-yl(m-methylstyryl) ketone
CAS 13662-57-2C22H18O
(2E)-3-(2,4-Dichlorophenyl)-1-(4-phenylphenyl)prop-2-en-1-one chemical structure, C21H14Cl2O, CAS 343600-24-8
(2E)-3-(2,4-Dichlorophenyl)-1-(4-phenylphenyl)prop-2-en-1-one
CAS 343600-24-8C21H14Cl2O
Biphenyl-4-yl(p-methoxystyryl) ketone chemical structure, C22H18O2, CAS 102692-38-6
Biphenyl-4-yl(p-methoxystyryl) ketone
CAS 102692-38-6C22H18O2
(E)-3-(3-Bromophenyl)-1-(4-phenylphenyl)prop-2-en-1-one chemical structure, C21H15BrO, CAS 1046051-15-3
(E)-3-(3-Bromophenyl)-1-(4-phenylphenyl)prop-2-en-1-one
CAS 1046051-15-3C21H15BrO
3,4-Dichloro-4'-phenylchalcone chemical structure, C21H14Cl2O, CAS 156426-63-0
3,4-Dichloro-4'-phenylchalcone
CAS 156426-63-0C21H14Cl2O
(2E)-1-(Biphenyl-4-yl)-3-(2-hydroxyphenyl)prop-2-en-1-one chemical structure, C21H16O2, CAS 132971-90-5
(2E)-1-(Biphenyl-4-yl)-3-(2-hydroxyphenyl)prop-2-en-1-one
CAS 132971-90-5C21H16O2
(2E)-3-(4-Fluorophenyl)-1-(4-phenylphenyl)prop-2-en-1-one chemical structure, C21H15FO, CAS 1620136-75-5
(2E)-3-(4-Fluorophenyl)-1-(4-phenylphenyl)prop-2-en-1-one
CAS 1620136-75-5C21H15FO