Free for buyers, contact details stay privateFree for buyers. Your contact details stay private until you accept a quote.

Sign in Join free

Murcko scaffold

4(5H)-Thiazolone, 5-(phenylmethylene)-2-(1-piperidinyl)- scaffold

48 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 19
Chemicals: 48
With full pages: 8

Scaffold SMILES

O=C1N=C(N2CCCCC2)SC1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 4(5H)-Thiazolone, 5-(phenylmethylene)-2-(1-piperidinyl)- page

Murcko scaffold O=C1N=C(N2CCCCC2)SC1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 48 chemicals

5-(4-Chlorobenzylidene)-2-(1-piperidinyl)-1,3-thiazol-4(5H)-one chemical structure, C15H15ClN2OS, CAS 83539-34-8

5-(4-Chlorobenzylidene)-2-(1-piperidinyl)-1,3-thiazol-4(5H)-one

CAS 83539-34-8C₁₅H₁₅ClN₂OS

4(5H)-Thiazolone, 5-((2-hydroxyphenyl)methylene)-2-(1-piperidinyl)-, (E)- chemical structure, C15H16N2O2S, CAS 81154-05-4

4(5H)-Thiazolone, 5-((2-hydroxyphenyl)methylene)-2-(1-piperidinyl)-, (E)-

CAS 81154-05-4C₁₅H₁₆N₂O₂S

(5Z)-2-Piperidino-5-(3-methoxy-4-hydroxybenzylidene)-2-thiazoline-4-one chemical structure, C16H18N2O3S, CAS 1347744-81-3

(5Z)-2-Piperidino-5-(3-methoxy-4-hydroxybenzylidene)-2-thiazoline-4-one

CAS 1347744-81-3C₁₆H₁₈N₂O₃S

(5E)-5-[[4-(Diethylamino)phenyl]methylidene]-2-piperidin-1-yl-1,3-thiazol-4-one chemical structure, C19H25N3OS, CAS 15788-46-2

(5E)-5-[[4-(Diethylamino)phenyl]methylidene]-2-piperidin-1-yl-1,3-thiazol-4-one

CAS 15788-46-2C₁₉H₂₅N₃OS

(5Z)-5-[(3-Ethoxy-4-hydroxyphenyl)methylidene]-2-(4-methylpiperidin-1-yl)-1,3-thiazol-4-one chemical structure, C18H22N2O3S, CAS 312290-48-5

(5Z)-5-[(3-Ethoxy-4-hydroxyphenyl)methylidene]-2-(4-methylpiperidin-1-yl)-1,3-thiazol-4-one

CAS 312290-48-5C₁₈H₂₂N₂O₃S

(5E)-5-[(4-Methoxyphenyl)methylidene]-2-piperidin-1-yl-1,3-thiazol-4-one chemical structure, C16H18N2O2S, CAS 83539-31-5

(5E)-5-[(4-Methoxyphenyl)methylidene]-2-piperidin-1-yl-1,3-thiazol-4-one

CAS 83539-31-5C₁₆H₁₈N₂O₂S

(5E)-5-[(4-Ethoxyphenyl)methylidene]-2-piperidin-1-yl-1,3-thiazol-4-one chemical structure, C17H20N2O2S, CAS 328090-56-8

(5E)-5-[(4-Ethoxyphenyl)methylidene]-2-piperidin-1-yl-1,3-thiazol-4-one

CAS 328090-56-8C₁₇H₂₀N₂O₂S

(5Z)-5-[(2-Methoxyphenyl)methylidene]-2-piperidin-1-yl-1,3-thiazol-4-one chemical structure, C16H18N2O2S, CAS 81183-03-1

(5Z)-5-[(2-Methoxyphenyl)methylidene]-2-piperidin-1-yl-1,3-thiazol-4-one

CAS 81183-03-1C₁₆H₁₈N₂O₂S

5-(3-Hydroxybenzylidene)-2-(1-piperidinyl)-1,3-thiazol-4(5H)-one chemical structure, C15H16N2O2S, CAS 1181082-26-7

5-(3-Hydroxybenzylidene)-2-(1-piperidinyl)-1,3-thiazol-4(5H)-one

CAS 1181082-26-7C₁₅H₁₆N₂O₂S

(5E)-5-[(2-Ethoxyphenyl)methylidene]-2-piperidin-1-yl-1,3-thiazol-4-one chemical structure, C17H20N2O2S, CAS 370855-68-8

(5E)-5-[(2-Ethoxyphenyl)methylidene]-2-piperidin-1-yl-1,3-thiazol-4-one

CAS 370855-68-8C₁₇H₂₀N₂O₂S

(E)-5-Benzylidene-2-(piperidin-1-yl)thiazol-4(5H)-one chemical structure, C15H16N2OS, CAS 83539-28-0

(E)-5-Benzylidene-2-(piperidin-1-yl)thiazol-4(5H)-one

CAS 83539-28-0C₁₅H₁₆N₂OS

5-(2-Fluoro-benzylidene)-2-piperidin-1-yl-thiazol-4-one chemical structure, C15H15FN2OS, CAS 1181815-84-8

5-(2-Fluoro-benzylidene)-2-piperidin-1-yl-thiazol-4-one

CAS 1181815-84-8C₁₅H₁₅FN₂OS

(5E)-2-Piperidin-1-yl-5-[(4-propan-2-yloxyphenyl)methylidene]-1,3-thiazol-4-one chemical structure, C18H22N2O2S, CAS 371133-42-5

(5E)-2-Piperidin-1-yl-5-[(4-propan-2-yloxyphenyl)methylidene]-1,3-thiazol-4-one

CAS 371133-42-5C₁₈H₂₂N₂O₂S

(5Z)-5-(3-Ethoxy-4-hydroxybenzylidene)-2-(piperidin-1-yl)-1,3-thiazol-4(5H)-one chemical structure, C17H20N2O3S, CAS 372974-82-8

(5Z)-5-(3-Ethoxy-4-hydroxybenzylidene)-2-(piperidin-1-yl)-1,3-thiazol-4(5H)-one

CAS 372974-82-8C₁₇H₂₀N₂O₃S

(E)-5-(3-Nitrobenzylidene)-2-(piperidin-1-yl)thiazol-4(5H)-one chemical structure, C15H15N3O3S, CAS 36937-42-5

(E)-5-(3-Nitrobenzylidene)-2-(piperidin-1-yl)thiazol-4(5H)-one

CAS 36937-42-5C₁₅H₁₅N₃O₃S

(5E)-5-[[3-Methoxy-4-(3-methylbutoxy)phenyl]methylidene]-2-piperidin-1-yl-1,3-thiazol-4-one chemical structure, C21H28N2O3S, CAS 381204-06-4

(5E)-5-[[3-Methoxy-4-(3-methylbutoxy)phenyl]methylidene]-2-piperidin-1-yl-1,3-thiazol-4-one

CAS 381204-06-4C₂₁H₂₈N₂O₃S

(E)-1-(5-(2,4-Dichlorobenzylidene)-4-oxo-4,5-dihydrothiazol-2-yl)piperidine-4-carboxamide chemical structure, C16H15Cl2N3O2S, CAS 519034-65-2

(E)-1-(5-(2,4-Dichlorobenzylidene)-4-oxo-4,5-dihydrothiazol-2-yl)piperidine-4-carboxamide

CAS 519034-65-2C₁₆H₁₅Cl₂N₃O₂S

1-[(5Z)-5-[(2,4-Dichlorophenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]piperidine-4-carboxamide chemical structure, C16H15Cl2N3O2S

1-[(5Z)-5-[(2,4-Dichlorophenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]piperidine-4-carboxamide

C₁₆H₁₅Cl₂N₃O₂S

(Z)-Ethyl 1-(5-(4-(dimethylamino)benzylidene)-4-oxo-4,5-dihydrothiazol-2-yl)piperidine-4-carboxylate chemical structure, C20H25N3O3S, CAS 309288-76-4

(Z)-Ethyl 1-(5-(4-(dimethylamino)benzylidene)-4-oxo-4,5-dihydrothiazol-2-yl)piperidine-4-carboxylate

CAS 309288-76-4C₂₀H₂₅N₃O₃S

5-(4-Isopropylbenzylidene)-2-(1-piperidinyl)-1,3-thiazol-4(5H)-one chemical structure, C18H22N2OS, CAS 311796-90-4

5-(4-Isopropylbenzylidene)-2-(1-piperidinyl)-1,3-thiazol-4(5H)-one

CAS 311796-90-4C₁₈H₂₂N₂OS

(5Z)-5-Benzylidene-2-(4-methylpiperidin-1-yl)-1,3-thiazol-4-one chemical structure, C16H18N2OS, CAS 1105571-62-7

(5Z)-5-Benzylidene-2-(4-methylpiperidin-1-yl)-1,3-thiazol-4-one

CAS 1105571-62-7C₁₆H₁₈N₂OS

(E)-5-Benzylidene-2-(4-methylpiperidin-1-yl)thiazol-4(5H)-one chemical structure, C16H18N2OS, CAS 339321-00-5

(E)-5-Benzylidene-2-(4-methylpiperidin-1-yl)thiazol-4(5H)-one

CAS 339321-00-5C₁₆H₁₈N₂OS

(5Z)-5-[(2,4-Dimethoxyphenyl)methylidene]-2-(4-methylpiperidin-1-yl)-1,3-thiazol-4-one chemical structure, C18H22N2O3S, CAS 312265-77-3

(5Z)-5-[(2,4-Dimethoxyphenyl)methylidene]-2-(4-methylpiperidin-1-yl)-1,3-thiazol-4-one

CAS 312265-77-3C₁₈H₂₂N₂O₃S

(5E)-5-[(2-Butoxyphenyl)methylidene]-2-piperidin-1-yl-1,3-thiazol-4-one chemical structure, C19H24N2O2S, CAS 371925-17-6

(5E)-5-[(2-Butoxyphenyl)methylidene]-2-piperidin-1-yl-1,3-thiazol-4-one

CAS 371925-17-6C₁₉H₂₄N₂O₂S