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Murcko scaffold

Ring system with 3 rings and 23 atoms

20 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
20
With full pages
6
Scaffold SMILES

O=C(NCCc1ccccc1)C1CC(=O)N(c2ccccc2)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCCc1ccccc1)C1CC(=O)N(c2ccccc2)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

1-(4-Ethylphenyl)-N-[2-(4-methoxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxamide chemical structure, C22H26N2O3, CAS 359686-44-5
1-(4-Ethylphenyl)-N-[2-(4-methoxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxamide
CAS 359686-44-5C22H26N2O3
1-(4-Bromophenyl)-N-[2-(4-chlorophenyl)ethyl]-5-oxopyrrolidine-3-carboxamide chemical structure, C19H18BrClN2O2, CAS 333352-05-9
1-(4-Bromophenyl)-N-[2-(4-chlorophenyl)ethyl]-5-oxopyrrolidine-3-carboxamide
CAS 333352-05-9C19H18BrClN2O2
1-(4-Bromophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxamide chemical structure, C21H23BrN2O4, CAS 351494-38-7
1-(4-Bromophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxamide
CAS 351494-38-7C21H23BrN2O4
1-(4-Fluorophenyl)-N-[2-(4-methoxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxamide chemical structure, C20H21FN2O3, CAS 425616-32-6
1-(4-Fluorophenyl)-N-[2-(4-methoxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxamide
CAS 425616-32-6C20H21FN2O3
N-[2-(3,4-Dimethoxyphenyl)ethyl]-1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C21H23FN2O4, CAS 403815-81-6
N-[2-(3,4-Dimethoxyphenyl)ethyl]-1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxamide
CAS 403815-81-6C21H23FN2O4
1-(4-Bromophenyl)-N-[2-(4-methoxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxamide chemical structure, C20H21BrN2O3, CAS 331986-61-9
1-(4-Bromophenyl)-N-[2-(4-methoxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxamide
CAS 331986-61-9C20H21BrN2O3
1-(4-Chlorophenyl)-N-[2-(4-chlorophenyl)ethyl]-5-oxopyrrolidine-3-carboxamide chemical structure, C19H18Cl2N2O2, CAS 670234-82-9
1-(4-Chlorophenyl)-N-[2-(4-chlorophenyl)ethyl]-5-oxopyrrolidine-3-carboxamide
CAS 670234-82-9C19H18Cl2N2O2
1-(4-Chlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxamide chemical structure, C21H23ClN2O4, CAS 404006-54-8
1-(4-Chlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxamide
CAS 404006-54-8C21H23ClN2O4
N-[2-(3,4-Dimethoxyphenyl)ethyl]-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C22H26N2O5, CAS 296893-39-5
N-[2-(3,4-Dimethoxyphenyl)ethyl]-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 296893-39-5C22H26N2O5
1-(4-Chlorophenyl)-5-oxo-N-(2-phenylethyl)pyrrolidine-3-carboxamide chemical structure, C19H19ClN2O2, CAS 331004-19-4
1-(4-Chlorophenyl)-5-oxo-N-(2-phenylethyl)pyrrolidine-3-carboxamide
CAS 331004-19-4C19H19ClN2O2
1-(4-Butoxyphenyl)-5-oxo-N-(2-phenylethyl)pyrrolidine-3-carboxamide chemical structure, C23H28N2O3, CAS 440109-29-5
1-(4-Butoxyphenyl)-5-oxo-N-(2-phenylethyl)pyrrolidine-3-carboxamide
CAS 440109-29-5C23H28N2O3
N-[2-(4-Chlorophenyl)ethyl]-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C20H21ClN2O2, CAS 341007-41-8
N-[2-(4-Chlorophenyl)ethyl]-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 341007-41-8C20H21ClN2O2
N-[2-(3,4-Dimethoxyphenyl)ethyl]-5-oxo-1-(4-propoxyphenyl)-3-pyrrolidinecarboxamide chemical structure, C24H30N2O5, CAS 443636-23-5
N-[2-(3,4-Dimethoxyphenyl)ethyl]-5-oxo-1-(4-propoxyphenyl)-3-pyrrolidinecarboxamide
CAS 443636-23-5C24H30N2O5
1-(4-Methylphenyl)-5-oxo-N-[2-(4-sulfamoylphenyl)ethyl]pyrrolidine-3-carboxamide chemical structure, C20H23N3O4S, CAS 825597-80-6
1-(4-Methylphenyl)-5-oxo-N-[2-(4-sulfamoylphenyl)ethyl]pyrrolidine-3-carboxamide
CAS 825597-80-6C20H23N3O4S
1-(4-Bromophenyl)-5-oxo-N-(2-phenylethyl)pyrrolidine-3-carboxamide chemical structure, C19H19BrN2O2, CAS 332027-06-2
1-(4-Bromophenyl)-5-oxo-N-(2-phenylethyl)pyrrolidine-3-carboxamide
CAS 332027-06-2C19H19BrN2O2
1-(3-Methoxyphenyl)-5-oxo-N-(2-phenylethyl)pyrrolidine-3-carboxamide chemical structure, C20H22N2O3, CAS 931374-01-5
1-(3-Methoxyphenyl)-5-oxo-N-(2-phenylethyl)pyrrolidine-3-carboxamide
CAS 931374-01-5C20H22N2O3
1-(4-Chlorophenyl)-5-oxo-N-[2-(4-sulfamoylphenyl)ethyl]pyrrolidine-3-carboxamide chemical structure, C19H20ClN3O4S, CAS 897748-37-7
1-(4-Chlorophenyl)-5-oxo-N-[2-(4-sulfamoylphenyl)ethyl]pyrrolidine-3-carboxamide
CAS 897748-37-7C19H20ClN3O4S
1-(3-Methoxyphenyl)-5-oxo-N-[2-(4-sulfamoylphenyl)ethyl]pyrrolidine-3-carboxamide chemical structure, C20H23N3O5S, CAS 1009261-33-9
1-(3-Methoxyphenyl)-5-oxo-N-[2-(4-sulfamoylphenyl)ethyl]pyrrolidine-3-carboxamide
CAS 1009261-33-9C20H23N3O5S
N-(2-Methoxy-2-(o-tolyl)ethyl)-5-oxo-1-phenylpyrrolidine-3-carboxamide chemical structure, C21H24N2O3, CAS 1797556-36-5
N-(2-Methoxy-2-(o-tolyl)ethyl)-5-oxo-1-phenylpyrrolidine-3-carboxamide
CAS 1797556-36-5C21H24N2O3
N-[2-Methoxy-2-(2-methoxyphenyl)ethyl]-5-oxo-1-phenylpyrrolidine-3-carboxamide chemical structure, C21H24N2O4, CAS 1795088-09-3
N-[2-Methoxy-2-(2-methoxyphenyl)ethyl]-5-oxo-1-phenylpyrrolidine-3-carboxamide
CAS 1795088-09-3C21H24N2O4