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Murcko scaffold

Ring system with 3 rings and 22 atoms

58 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
58
With full pages
6
Scaffold SMILES

O=C(NCc1ccccc1)C1CC(=O)N(c2ccccc2)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCc1ccccc1)C1CC(=O)N(c2ccccc2)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 58 chemicals

N-Benzyl-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H20N2O2, CAS 333352-41-3
N-Benzyl-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 333352-41-3C19H20N2O2
N-[(4-Chlorophenyl)methyl]-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H19ClN2O3, CAS 296893-34-0
N-[(4-Chlorophenyl)methyl]-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 296893-34-0C19H19ClN2O3
1-(4-Methoxy-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid 3-methyl-benzylamide chemical structure, C20H22N2O3, CAS 446053-91-4
1-(4-Methoxy-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid 3-methyl-benzylamide
CAS 446053-91-4C20H22N2O3
N-[(4-Ethylphenyl)methyl]-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C21H24N2O3, CAS 405277-03-4
N-[(4-Ethylphenyl)methyl]-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 405277-03-4C21H24N2O3
1-(4-Ethoxyphenyl)-N-(3-methylbenzyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C21H24N2O3, CAS 446053-83-4
1-(4-Ethoxyphenyl)-N-(3-methylbenzyl)-5-oxopyrrolidine-3-carboxamide
CAS 446053-83-4C21H24N2O3
N-Benzyl-1-(4-chlorophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H17ClN2O2, CAS 332065-17-5
N-Benzyl-1-(4-chlorophenyl)-5-oxopyrrolidine-3-carboxamide
CAS 332065-17-5C18H17ClN2O2
N-Benzyl-1-(4-bromophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H17BrN2O2, CAS 331981-74-9
N-Benzyl-1-(4-bromophenyl)-5-oxopyrrolidine-3-carboxamide
CAS 331981-74-9C18H17BrN2O2
N-(2-Chlorobenzyl)-1-(3-nitrophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H16ClN3O4, CAS 333352-72-0
N-(2-Chlorobenzyl)-1-(3-nitrophenyl)-5-oxopyrrolidine-3-carboxamide
CAS 333352-72-0C18H16ClN3O4
1-(4-Bromophenyl)-5-oxo-N-(1-phenylethyl)pyrrolidine-3-carboxamide chemical structure, C19H19BrN2O2, CAS 306746-53-2
1-(4-Bromophenyl)-5-oxo-N-(1-phenylethyl)pyrrolidine-3-carboxamide
CAS 306746-53-2C19H19BrN2O2
1-(4-Ethylphenyl)-N-[(2-methoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxamide chemical structure, C21H24N2O3, CAS 425416-95-1
1-(4-Ethylphenyl)-N-[(2-methoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxamide
CAS 425416-95-1C21H24N2O3
1-(4-Ethylphenyl)-N-(4-methylbenzyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C21H24N2O2, CAS 425609-44-5
1-(4-Ethylphenyl)-N-(4-methylbenzyl)-5-oxopyrrolidine-3-carboxamide
CAS 425609-44-5C21H24N2O2
1-(4-Fluorophenyl)-N-(2-methoxybenzyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H19FN2O3, CAS 404350-81-8
1-(4-Fluorophenyl)-N-(2-methoxybenzyl)-5-oxopyrrolidine-3-carboxamide
CAS 404350-81-8C19H19FN2O3
N-[(4-Chlorophenyl)methyl]-1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H16ClFN2O2, CAS 331986-68-6
N-[(4-Chlorophenyl)methyl]-1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxamide
CAS 331986-68-6C18H16ClFN2O2
N-(2-Methoxybenzyl)-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C20H22N2O3, CAS 425625-91-8
N-(2-Methoxybenzyl)-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 425625-91-8C20H22N2O3
1-(4-Bromophenyl)-N-(4-methylbenzyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H19BrN2O2, CAS 425626-71-7
1-(4-Bromophenyl)-N-(4-methylbenzyl)-5-oxopyrrolidine-3-carboxamide
CAS 425626-71-7C19H19BrN2O2
N-(4-Chlorobenzyl)-1-(4-chlorophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H16Cl2N2O2, CAS 371930-32-4
N-(4-Chlorobenzyl)-1-(4-chlorophenyl)-5-oxopyrrolidine-3-carboxamide
CAS 371930-32-4C18H16Cl2N2O2
1-(4-Methylphenyl)-N-[(4-methylphenyl)methyl]-5-oxopyrrolidine-3-carboxamide chemical structure, C20H22N2O2, CAS 333438-39-4
1-(4-Methylphenyl)-N-[(4-methylphenyl)methyl]-5-oxopyrrolidine-3-carboxamide
CAS 333438-39-4C20H22N2O2
1-(4-Bromophenyl)-N-[(2-methoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxamide chemical structure, C19H19BrN2O3, CAS 341926-43-0
1-(4-Bromophenyl)-N-[(2-methoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxamide
CAS 341926-43-0C19H19BrN2O3
1-(4-Ethoxyphenyl)-N-[(2-methylphenyl)methyl]-5-oxopyrrolidine-3-carboxamide chemical structure, C21H24N2O3, CAS 346456-83-5
1-(4-Ethoxyphenyl)-N-[(2-methylphenyl)methyl]-5-oxopyrrolidine-3-carboxamide
CAS 346456-83-5C21H24N2O3
1-(4-Ethoxyphenyl)-N-(2-methoxybenzyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C21H24N2O4, CAS 309928-64-1
1-(4-Ethoxyphenyl)-N-(2-methoxybenzyl)-5-oxopyrrolidine-3-carboxamide
CAS 309928-64-1C21H24N2O4
N-[(2-Chlorophenyl)methyl]-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H19ClN2O2, CAS 340320-00-5
N-[(2-Chlorophenyl)methyl]-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 340320-00-5C19H19ClN2O2
1-(4-Methoxyphenyl)-N-[(2-methylphenyl)methyl]-5-oxopyrrolidine-3-carboxamide chemical structure, C20H22N2O3, CAS 440109-31-9
1-(4-Methoxyphenyl)-N-[(2-methylphenyl)methyl]-5-oxopyrrolidine-3-carboxamide
CAS 440109-31-9C20H22N2O3
1-(3,4-Dichlorophenyl)-N-(4-methoxybenzyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H18Cl2N2O3, CAS 309928-63-0
1-(3,4-Dichlorophenyl)-N-(4-methoxybenzyl)-5-oxopyrrolidine-3-carboxamide
CAS 309928-63-0C19H18Cl2N2O3
1-(3,4-Dimethylphenyl)-N-(2-methoxybenzyl)-5-oxo-3-pyrrolidinecarboxamide chemical structure, C21H24N2O3, CAS 499111-42-1
1-(3,4-Dimethylphenyl)-N-(2-methoxybenzyl)-5-oxo-3-pyrrolidinecarboxamide
CAS 499111-42-1C21H24N2O3