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Murcko scaffold

6-Oxa-2-azaspiro[3.4]octan-7-one scaffold

43 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
9
Chemicals
43
With full pages
3
Scaffold SMILES

O=C1CC2(CNC2)CO1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 6-Oxa-2-azaspiro[3.4]octan-7-one page
Murcko scaffold O=C1CC2(CNC2)CO1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 43 of 43 chemicals

tert-Butyl 5-(iodomethyl)-7-oxo-6-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H18INO4, CAS 2138227-36-6
tert-Butyl 5-(iodomethyl)-7-oxo-6-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 2138227-36-6C12H18INO4
Oxalic acid, tert-butyl 5-(aminomethyl)-7-oxo-6-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C14H22N2O8, CAS 2138426-34-1
Oxalic acid, tert-butyl 5-(aminomethyl)-7-oxo-6-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 2138426-34-1C14H22N2O8
tert-Butyl 5-(aminomethyl)-7-oxo-6-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H20N2O4, CAS 2137590-31-7
tert-Butyl 5-(aminomethyl)-7-oxo-6-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 2137590-31-7C12H20N2O4
tert-Butyl 5-[(fluorosulfonyl)methyl]-7-oxo-6-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H18FNO6S, CAS 2172276-14-9
tert-Butyl 5-[(fluorosulfonyl)methyl]-7-oxo-6-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 2172276-14-9C12H18FNO6S
tert-Butyl 5-[(chlorosulfonyl)methyl]-7-oxo-6-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H18ClNO6S, CAS 2225144-48-7
tert-Butyl 5-[(chlorosulfonyl)methyl]-7-oxo-6-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 2225144-48-7C12H18ClNO6S
tert-Butyl 5-fluoro-5-(iodomethyl)-7-oxo-6-oxa-2-azaspiro(3.4)octane-2-carboxylate chemical structure, C12H17FINO4, CAS 2225137-29-9
tert-Butyl 5-fluoro-5-(iodomethyl)-7-oxo-6-oxa-2-azaspiro(3.4)octane-2-carboxylate
CAS 2225137-29-9C12H17FINO4
5-{[Ethyl(2-hydroxyethyl)amino]methyl}-6-oxa-2-azaspiro[3.4]octan-7-one chemical structure, C11H20N2O3, CAS 2137812-34-9
5-{[Ethyl(2-hydroxyethyl)amino]methyl}-6-oxa-2-azaspiro[3.4]octan-7-one
CAS 2137812-34-9C11H20N2O3
5-{[Ethyl(propan-2-yl)amino]methyl}-6-oxa-2-azaspiro[3.4]octan-7-one chemical structure, C12H22N2O2, CAS 2138337-68-3
5-{[Ethyl(propan-2-yl)amino]methyl}-6-oxa-2-azaspiro[3.4]octan-7-one
CAS 2138337-68-3C12H22N2O2
5-[(Dibutylamino)methyl]-6-oxa-2-azaspiro[3.4]octan-7-one chemical structure, C15H28N2O2, CAS 2137801-43-3
5-[(Dibutylamino)methyl]-6-oxa-2-azaspiro[3.4]octan-7-one
CAS 2137801-43-3C15H28N2O2
5-{[Butyl(methyl)amino]methyl}-6-oxa-2-azaspiro[3.4]octan-7-one chemical structure, C12H22N2O2, CAS 2137801-48-8
5-{[Butyl(methyl)amino]methyl}-6-oxa-2-azaspiro[3.4]octan-7-one
CAS 2137801-48-8C12H22N2O2
5-{[Bis(2-hydroxyethyl)amino]methyl}-6-oxa-2-azaspiro[3.4]octan-7-one chemical structure, C11H20N2O4, CAS 2138134-82-2
5-{[Bis(2-hydroxyethyl)amino]methyl}-6-oxa-2-azaspiro[3.4]octan-7-one
CAS 2138134-82-2C11H20N2O4
5-{[(2-Methoxyethyl)(methyl)amino]methyl}-6-oxa-2-azaspiro[3.4]octan-7-one chemical structure, C11H20N2O3, CAS 2137651-47-7
5-{[(2-Methoxyethyl)(methyl)amino]methyl}-6-oxa-2-azaspiro[3.4]octan-7-one
CAS 2137651-47-7C11H20N2O3
5-{[Ethyl(propyl)amino]methyl}-6-oxa-2-azaspiro[3.4]octan-7-one chemical structure, C12H22N2O2, CAS 2137801-87-5
5-{[Ethyl(propyl)amino]methyl}-6-oxa-2-azaspiro[3.4]octan-7-one
CAS 2137801-87-5C12H22N2O2
2-Methoxy-N-({7-oxo-6-oxa-2-azaspiro[3.4]octan-5-yl}methyl)acetamide chemical structure, C10H16N2O4, CAS 2138143-69-6
2-Methoxy-N-({7-oxo-6-oxa-2-azaspiro[3.4]octan-5-yl}methyl)acetamide
CAS 2138143-69-6C10H16N2O4
2-Methyl-N-({7-oxo-6-oxa-2-azaspiro[3.4]octan-5-yl}methyl)propanamide chemical structure, C11H18N2O3, CAS 2138407-00-6
2-Methyl-N-({7-oxo-6-oxa-2-azaspiro[3.4]octan-5-yl}methyl)propanamide
CAS 2138407-00-6C11H18N2O3
N-({7-Oxo-6-oxa-2-azaspiro[3.4]octan-5-yl}methyl)butanamide chemical structure, C11H18N2O3, CAS 2137549-70-1
N-({7-Oxo-6-oxa-2-azaspiro[3.4]octan-5-yl}methyl)butanamide
CAS 2137549-70-1C11H18N2O3
2,2-Dimethyl-N-({7-oxo-6-oxa-2-azaspiro[3.4]octan-5-yl}methyl)propanamide chemical structure, C12H20N2O3, CAS 2138514-19-7
2,2-Dimethyl-N-({7-oxo-6-oxa-2-azaspiro[3.4]octan-5-yl}methyl)propanamide
CAS 2138514-19-7C12H20N2O3
5-(Iodomethyl)-6-oxa-2-azaspiro[3.4]octan-7-one chemical structure, C7H10INO2, CAS 2169512-50-7
5-(Iodomethyl)-6-oxa-2-azaspiro[3.4]octan-7-one
CAS 2169512-50-7C7H10INO2
3-Methoxy-N-({7-oxo-6-oxa-2-azaspiro[3.4]octan-5-yl}methyl)propanamide chemical structure, C11H18N2O4, CAS 2137565-05-8
3-Methoxy-N-({7-oxo-6-oxa-2-azaspiro[3.4]octan-5-yl}methyl)propanamide
CAS 2137565-05-8C11H18N2O4
2,3-Dimethyl-N-({7-oxo-6-oxa-2-azaspiro[3.4]octan-5-yl}methyl)butanamide chemical structure, C13H22N2O3, CAS 2137771-18-5
2,3-Dimethyl-N-({7-oxo-6-oxa-2-azaspiro[3.4]octan-5-yl}methyl)butanamide
CAS 2137771-18-5C13H22N2O3
{7-Oxo-6-oxa-2-azaspiro[3.4]octan-5-yl}methanesulfonyl fluoride chemical structure, C7H10FNO4S, CAS 2169144-04-9
{7-Oxo-6-oxa-2-azaspiro[3.4]octan-5-yl}methanesulfonyl fluoride
CAS 2169144-04-9C7H10FNO4S
5-(Aminomethyl)-6-oxa-2-azaspiro[3.4]octan-7-one chemical structure, C7H12N2O2, CAS 2168413-50-9
5-(Aminomethyl)-6-oxa-2-azaspiro[3.4]octan-7-one
CAS 2168413-50-9C7H12N2O2
5-[(Dipropylamino)methyl]-6-oxa-2-azaspiro[3.4]octan-7-one chemical structure, C13H24N2O2, CAS 2137633-56-6
5-[(Dipropylamino)methyl]-6-oxa-2-azaspiro[3.4]octan-7-one
CAS 2137633-56-6C13H24N2O2
5-(Azidomethyl)-6-oxa-2-azaspiro[3.4]octan-7-one chemical structure, C7H10N4O2, CAS 2168187-26-4
5-(Azidomethyl)-6-oxa-2-azaspiro[3.4]octan-7-one
CAS 2168187-26-4C7H10N4O2