Murcko scaffold
5-Azaspiro[3.4]octane scaffold
157 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 8
- Chemicals
- 157
- With full pages
- 32
Scaffold SMILES
C1CNC2(C1)CCC2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 157 chemicals
![5-Azaspiro[3.4]octane chemical structure, C7H13N, CAS 52876-78-5](/s/FOMNEVDLMZUAJY-UHFFFAOYSA-N.svg)
5-Azaspiro[3.4]octane
CAS 52876-78-5C7H13N
![tert-Butyl 2-cyano-5-azaspiro[3.4]octane-5-carboxylate chemical structure, C13H20N2O2, CAS 1374658-97-5](/s/WYCNLUXRGLFHJA-UHFFFAOYSA-N.svg)
tert-Butyl 2-cyano-5-azaspiro[3.4]octane-5-carboxylate
CAS 1374658-97-5C13H20N2O2
![5-(tert-Butoxycarbonyl)-5-azaspiro[3.4]octane-2-carboxylic acid chemical structure, C13H21NO4, CAS 1363381-67-2](/s/JPRDSXJTSHIDCU-UHFFFAOYSA-N.svg)
5-(tert-Butoxycarbonyl)-5-azaspiro[3.4]octane-2-carboxylic acid
CAS 1363381-67-2C13H21NO4
![tert-Butyl 2-amino-5-azaspiro[3.4]octane-5-carboxylate chemical structure, C12H22N2O2, CAS 1363380-49-7](/s/HKJVUMPWNMAHSI-UHFFFAOYSA-N.svg)
tert-Butyl 2-amino-5-azaspiro[3.4]octane-5-carboxylate
CAS 1363380-49-7C12H22N2O2
![5-Azaspiro[3.4]octan-7-ylmethanol hydrochloride chemical structure, C8H16ClNO, CAS 1823371-51-2](/s/YOECBERYCMVKDD-UHFFFAOYSA-N.svg)
5-Azaspiro[3.4]octan-7-ylmethanol hydrochloride
CAS 1823371-51-2C8H16ClNO
![{5-Azaspiro[3.4]octan-7-yl}methanol chemical structure, C8H15NO, CAS 1823371-50-1](/s/PDZDFXXMGUFNIQ-UHFFFAOYSA-N.svg)
{5-Azaspiro[3.4]octan-7-yl}methanol
CAS 1823371-50-1C8H15NO
![7-Methyl-5-azaspiro[3.4]octane hydrochloride chemical structure, C8H16ClN, CAS 1823381-46-9](/s/BCNGREKFUXAHSD-UHFFFAOYSA-N.svg)
7-Methyl-5-azaspiro[3.4]octane hydrochloride
CAS 1823381-46-9C8H16ClN
![7-Methyl-5-azaspiro[3.4]octane chemical structure, C8H15N, CAS 1823381-45-8](/s/IIQIKRQMNFHIFL-UHFFFAOYSA-N.svg)
7-Methyl-5-azaspiro[3.4]octane
CAS 1823381-45-8C8H15N
![Ethyl 5-boc-5-aza-spiro[3.4]octane-2-carboxylate chemical structure, C15H25NO4, CAS 1251022-90-8](/s/ZPPOQRXOWKVNJV-UHFFFAOYSA-N.svg)
Ethyl 5-boc-5-aza-spiro[3.4]octane-2-carboxylate
CAS 1251022-90-8C15H25NO4
![5-Aza-spiro[3.4]octane-2-carboxylic acid chemical structure, C8H13NO2, CAS 1363381-35-4](/s/XONSSESEMDOJJO-UHFFFAOYSA-N.svg)
5-Aza-spiro[3.4]octane-2-carboxylic acid
CAS 1363381-35-4C8H13NO2
![2-(Boc-amino)-5-aza-spiro[3.4]octane chemical structure, C12H22N2O2, CAS 1363381-16-1](/s/JSUVVSXSEJHJRL-UHFFFAOYSA-N.svg)
2-(Boc-amino)-5-aza-spiro[3.4]octane
CAS 1363381-16-1C12H22N2O2
tert-Butyl 5-azaspiro(3.4)octane-2-carboxylate
CAS 1986792-01-1C12H21NO2
![5-Azaspiro[3.4]octane oxalate chemical structure, C9H15NO4, CAS 1403766-69-7](/s/RUFZMAAVKZWUHW-UHFFFAOYSA-N.svg)
5-Azaspiro[3.4]octane oxalate
CAS 1403766-69-7C9H15NO4
![5-Azaspiro[3.4]octane-6-carboxylic acid chemical structure, C8H13NO2, CAS 1517190-53-2](/s/FWDYSHUATQNBEN-UHFFFAOYSA-N.svg)
5-Azaspiro[3.4]octane-6-carboxylic acid
CAS 1517190-53-2C8H13NO2
![{5-Azaspiro[3.4]octan-6-yl}methanol chemical structure, C8H15NO, CAS 1784389-88-3](/s/RQZQODJMAPNUOW-UHFFFAOYSA-N.svg)
{5-Azaspiro[3.4]octan-6-yl}methanol
CAS 1784389-88-3C8H15NO
Methyl 5-azaspiro(3.4)octane-6-carboxylate
CAS 1779647-65-2C9H15NO2
![5-Azaspiro[3.4]octane hydrobromide chemical structure, C7H14BrN, CAS 1795283-50-9](/s/VHBJJXPWYWDYDA-UHFFFAOYSA-N.svg)
5-Azaspiro[3.4]octane hydrobromide
CAS 1795283-50-9C7H14BrN
![5-Azaspiro[3.4]octane hemioxalate chemical structure, C16H28N2O4, CAS 1523618-05-4](/s/CSOGJCFXGYETQI-UHFFFAOYSA-N.svg)
5-Azaspiro[3.4]octane hemioxalate
CAS 1523618-05-4C16H28N2O4
![5-Azaspiro[3.4]octane-2-carboxylic acid hydrochloride chemical structure, C8H14ClNO2, CAS 1523606-22-5](/s/RXWBXEUCKHQFRH-UHFFFAOYSA-N.svg)
5-Azaspiro[3.4]octane-2-carboxylic acid hydrochloride
CAS 1523606-22-5C8H14ClNO2
![tert-Butyl 2-formyl-5-azaspiro[3.4]octane-5-carboxylate chemical structure, C13H21NO3, CAS 1434141-98-6](/s/OTOFLZYPQQYDNR-UHFFFAOYSA-N.svg)
tert-Butyl 2-formyl-5-azaspiro[3.4]octane-5-carboxylate
CAS 1434141-98-6C13H21NO3
![tert-Butyl 2-(hydroxymethyl)-5-azaspiro[3.4]octane-5-carboxylate chemical structure, C13H23NO3, CAS 1434141-76-0](/s/YYBNAYOJLLFZPA-UHFFFAOYSA-N.svg)
tert-Butyl 2-(hydroxymethyl)-5-azaspiro[3.4]octane-5-carboxylate
CAS 1434141-76-0C13H23NO3
![tert-Butyl 2-(aminomethyl)-5-azaspiro[3.4]octane-5-carboxylate chemical structure, C13H24N2O2, CAS 1638767-04-0](/s/WDACZZFUFAIDOL-UHFFFAOYSA-N.svg)
tert-Butyl 2-(aminomethyl)-5-azaspiro[3.4]octane-5-carboxylate
CAS 1638767-04-0C13H24N2O2
![tert-Butyl 8-hydroxy-5-azaspiro[3.4]octane-5-carboxylate chemical structure, C12H21NO3, CAS 1955492-98-4](/s/HGNCHMUMZPIMGE-UHFFFAOYSA-N.svg)
tert-Butyl 8-hydroxy-5-azaspiro[3.4]octane-5-carboxylate
CAS 1955492-98-4C12H21NO3
![tert-Butyl 2-hydroxy-5-azaspiro[3.4]octane-5-carboxylate chemical structure, C12H21NO3, CAS 1934835-43-4](/s/JNUGZOXEJAWXRI-UHFFFAOYSA-N.svg)
tert-Butyl 2-hydroxy-5-azaspiro[3.4]octane-5-carboxylate
CAS 1934835-43-4C12H21NO3
- 5-Azaspiro[3.4]octane-5-carboxamide1849296-01-0C8H14N2O
- tert-Butyl 8-amino-5-azaspiro[3.4]octane-5-carboxylate2044714-40-9C12H22N2O2
- 2-Fluoro-5-azaspiro[3.4]octane2092106-91-5C7H12FN
- 5-Azaspiro[3.4]octan-7-ol2090704-48-4C7H13NO
- Ethyl 5-azaspiro[3.4]octane-6-carboxylate2089697-24-3C10H17NO2
- 5-Azaspiro[3.4]octan-8-ol2092204-02-7C7H13NO
- 5-Azaspiro(3.4)octane hydrochloride2126159-45-1C7H14ClN
- Ethyl 5-azaspiro[3.4]octane-2-carboxylate2287273-84-9C10H17NO2
- Methyl (2r,4s)-5-azaspiro[3.4]octane-2-carboxylate2260917-57-3C9H15NO2
- Ethyl 5-azaspiro[3.4]octane-8-carboxylate hydrochloride2230807-44-8C10H18ClNO2
- Ethyl 5-azaspiro[3.4]octane-8-carboxylate2028342-10-9C10H17NO2
- tert-Butyl N-{5-azaspiro[3.4]octan-7-yl}carbamate2241130-97-0C12H22N2O2
- N,N-Dimethyl-5-azaspiro(3.4)octan-7-amine dihydrochloride2247102-00-5C9H20Cl2N2
- N,N-Dimethyl-5-azaspiro[3.4]octan-7-amine2247101-99-9C9H18N2
- 5-Azaspiro[3.4]octan-7-ol hydrochloride2247102-02-7C7H14ClNO
- 5-Methyl-5-azaspiro[3.4]octan-7-amine2243510-58-7C8H16N2
- 5-((tert-Butoxy)carbonyl)-5-azaspiro(3.4)octane-8-carboxylic acid2248347-48-8C13H21NO4
- 2,2-Difluoro-5-azaspiro[3.4]octane2167445-29-4C7H11F2N
- 5-Azaspiro[3.4]octan-8-ol hydrochloride2309455-45-4C7H14ClNO
- 5-Azaspiro(3.4)octane-7-carboxylic acid hydrochloride2344685-69-2C8H14ClNO2
- 5-Azaspiro[3.4]octane-7-carboxylic acid2344678-75-5C8H13NO2
- 5-[(tert-Butoxy)carbonyl]-5-azaspiro[3.4]octane-7-carboxylic acid2344679-45-2C13H21NO4
- 2-{5-[(tert-Butoxy)carbonyl]-5-azaspiro[3.4]octan-7-yl}acetic acid2344679-78-1C14H23NO4
- tert-Butyl N-(5-azaspiro[3.4]octan-7-ylmethyl)carbamate2361635-71-2C13H24N2O2
Related scaffolds
Same ring framework with different atoms or bond orders
C1CC2(C1)CCNC263 chemicals
C1COC2(C1)CNC230 chemicals
C1CCC2(C1)CCC229 chemicals
C1CC2(C1)CCOC218 chemicals
C1COC2(C1)CCC216 chemicals
C1CCC2(C1)CNC215 chemicals
C1CC2(CN1)CNC214 chemicals
C1CC2(CNC2)CO110 chemicals
C1CC2(CN1)COC210 chemicals
C1CC2(C1)OCCO28 chemicals
O=C1CC2(CNC2)CN17 chemicals
O=C1CC2(CCC2)CN17 chemicals