Murcko scaffold
2-Azaspiro(3.4)octane scaffold
124 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 8
- Chemicals
- 124
- With full pages
- 15
Scaffold SMILES
C1CCC2(C1)CNC2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 124 chemicals
2-Azaspiro(3.4)octane
CAS 665-41-8C7H13N
2-Boc-6-hydroxy-2-azaspiro(3.4)octane
CAS 1363381-95-6C12H21NO3
2-Azaspiro(3.4)octane hydrochloride
CAS 1414885-15-6C7H14ClN
![2-Azaspiro[3.4]octan-2-amine chemical structure, C7H14N2, CAS 1555263-48-3](/s/CFFJIDJLLZLCMD-UHFFFAOYSA-N.svg)
2-Azaspiro[3.4]octan-2-amine
CAS 1555263-48-3C7H14N2
![2-Azaspiro[3.4]octan-5-amine chemical structure, C7H14N2, CAS 1582035-05-9](/s/LTZOHILEDZWZPS-UHFFFAOYSA-N.svg)
2-Azaspiro[3.4]octan-5-amine
CAS 1582035-05-9C7H14N2
![2-Azaspiro[3.4]octane hemioxalate chemical structure, C16H28N2O4, CAS 1523617-94-8](/s/ZFBQBCHFEOUKDG-UHFFFAOYSA-N.svg)
2-Azaspiro[3.4]octane hemioxalate
CAS 1523617-94-8C16H28N2O4
![tert-Butyl 6-amino-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H22N2O2, CAS 1638763-38-8](/s/CTDSKHCAIGOHQU-UHFFFAOYSA-N.svg)
tert-Butyl 6-amino-2-azaspiro[3.4]octane-2-carboxylate
CAS 1638763-38-8C12H22N2O2
![tert-Butyl N-{2-azaspiro[3.4]octan-6-yl}carbamate chemical structure, C12H22N2O2, CAS 1638761-24-6](/s/FAWHTXUMVSKNOY-UHFFFAOYSA-N.svg)
tert-Butyl N-{2-azaspiro[3.4]octan-6-yl}carbamate
CAS 1638761-24-6C12H22N2O2
![tert-Butyl 2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H21NO2, CAS 1638771-23-9](/s/VHUPYWTWVSDQQT-UHFFFAOYSA-N.svg)
tert-Butyl 2-azaspiro[3.4]octane-2-carboxylate
CAS 1638771-23-9C12H21NO2
![tert-Butyl (6S)-6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H21NO3, CAS 2376903-72-7](/s/YFPCKEAWCYQRAV-VIFPVBQESA-N.svg)
tert-Butyl (6S)-6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate
CAS 2376903-72-7C12H21NO3
![tert-Butyl (6R)-6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H21NO3, CAS 2198241-68-6](/s/YFPCKEAWCYQRAV-SECBINFHSA-N.svg)
tert-Butyl (6R)-6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate
CAS 2198241-68-6C12H21NO3
![tert-Butyl 5-hydroxy-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H21NO3, CAS 1785382-09-3](/s/TVHDLLZTJKJWLM-UHFFFAOYSA-N.svg)
tert-Butyl 5-hydroxy-2-azaspiro[3.4]octane-2-carboxylate
CAS 1785382-09-3C12H21NO3
![2-Azaspiro[3.4]octan-6-ol hydrochloride chemical structure, C7H14ClNO, CAS 1638767-65-3](/s/JADQMCHEFMSALL-UHFFFAOYSA-N.svg)
2-Azaspiro[3.4]octan-6-ol hydrochloride
CAS 1638767-65-3C7H14ClNO
![2-Azaspiro[3.4]octan-6-ol chemical structure, C7H13NO, CAS 1638920-41-8](/s/JVEMDMMDFHXQSB-UHFFFAOYSA-N.svg)
2-Azaspiro[3.4]octan-6-ol
CAS 1638920-41-8C7H13NO
![6-Fluoro-2-azaspiro[3.4]octane hydrochloride chemical structure, C7H13ClFN, CAS 1638767-64-2](/s/UUADDXIRHCYBCN-UHFFFAOYSA-N.svg)
6-Fluoro-2-azaspiro[3.4]octane hydrochloride
CAS 1638767-64-2C7H13ClFN
![6-Fluoro-2-azaspiro[3.4]octane chemical structure, C7H12FN, CAS 1638920-40-7](/s/JLJQTTVQYSMYCP-UHFFFAOYSA-N.svg)
6-Fluoro-2-azaspiro[3.4]octane
CAS 1638920-40-7C7H12FN
![tert-Butyl 6,6-difluoro-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H19F2NO2, CAS 1638759-78-0](/s/VBDYEDZTIYYFKS-UHFFFAOYSA-N.svg)
tert-Butyl 6,6-difluoro-2-azaspiro[3.4]octane-2-carboxylate
CAS 1638759-78-0C12H19F2NO2
![1-(Propan-2-yl)-2-azaspiro[3.4]octane chemical structure, C10H19N, CAS 1849293-67-9](/s/HLTAWPYPYZTWSS-UHFFFAOYSA-N.svg)
1-(Propan-2-yl)-2-azaspiro[3.4]octane
CAS 1849293-67-9C10H19N
![2-Azaspiro[3.4]octane-1-carboxylic acid hydrochloride chemical structure, C8H14ClNO2, CAS 1989659-16-6](/s/GFILNOZNJLZHCO-UHFFFAOYSA-N.svg)
2-Azaspiro[3.4]octane-1-carboxylic acid hydrochloride
CAS 1989659-16-6C8H14ClNO2
![2-Azaspiro[3.4]octane-1-carboxylic acid chemical structure, C8H13NO2, CAS 1989659-15-5](/s/KPSWSDNHHBJSLK-UHFFFAOYSA-N.svg)
2-Azaspiro[3.4]octane-1-carboxylic acid
CAS 1989659-15-5C8H13NO2
![2-[(tert-Butoxy)carbonyl]-2-azaspiro[3.4]octane-1-carboxylic acid chemical structure, C13H21NO4, CAS 1955492-62-2](/s/UFRFPINAEOFOIN-UHFFFAOYSA-N.svg)
2-[(tert-Butoxy)carbonyl]-2-azaspiro[3.4]octane-1-carboxylic acid
CAS 1955492-62-2C13H21NO4
![tert-Butyl N-[(6R)-2-azaspiro[3.4]octan-6-yl]carbamate chemical structure, C12H22N2O2, CAS 2199215-50-2](/s/FAWHTXUMVSKNOY-SECBINFHSA-N.svg)
tert-Butyl N-[(6R)-2-azaspiro[3.4]octan-6-yl]carbamate
CAS 2199215-50-2C12H22N2O2
![tert-Butyl N-[(6S)-2-azaspiro[3.4]octan-6-yl]carbamate chemical structure, C12H22N2O2, CAS 2381901-62-6](/s/FAWHTXUMVSKNOY-VIFPVBQESA-N.svg)
tert-Butyl N-[(6S)-2-azaspiro[3.4]octan-6-yl]carbamate
CAS 2381901-62-6C12H22N2O2
![tert-Butyl (S)-6-amino-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H22N2O2, CAS 2381568-69-8](/s/CTDSKHCAIGOHQU-VIFPVBQESA-N.svg)
tert-Butyl (S)-6-amino-2-azaspiro[3.4]octane-2-carboxylate
CAS 2381568-69-8C12H22N2O2
- tert-Butyl (6R)-6-amino-2-azaspiro[3.4]octane-2-carboxylate2198241-46-0C12H22N2O2
- Methyl 2-azaspiro[3.4]octane-1-carboxylate hydrochloride2031258-52-1C9H16ClNO2
- Methyl 2-azaspiro[3.4]octane-1-carboxylate2031258-51-0C9H15NO2
- 2-Azaspiro[3.4]octane-2-carboxamide1849265-21-9C8H14N2O
- 2-((tert-Butoxy)carbonyl)-2-azaspiro(3.4)octane-6-carboxylic acid1936652-98-0C13H21NO4
- tert-Butyl 6-cyano-2-azaspiro[3.4]octane-2-carboxylate1935088-58-6C13H20N2O2
- tert-Butyl 6-(aminomethyl)-2-azaspiro[3.4]octane-2-carboxylate1934909-71-3C13H24N2O2
- 1-Methyl-2-azaspiro[3.4]octane1849345-09-0C8H15N
- tert-Butyl 2-azaspiro[3.4]octane-1-carboxylate2089692-96-4C12H21NO2
- rac-(6R,7R)-7-Amino-2-ethyl-1-(propan-2-yl)-2-azaspiro(3.4)octan-6-ol dihydrochloride2137440-08-3C12H26Cl2N2O
- rac-(6R,7R)-7-Amino-2-ethyl-1-(propan-2-yl)-2-azaspiro[3.4]octan-6-ol2137433-08-8C12H24N2O
- rac-tert-Butyl N-[(6R,7R)-7-hydroxy-1-(propan-2-yl)-2-azaspiro[3.4]octan-6-yl]carbamate hydrochloride2137434-42-3C15H29ClN2O3
- rac-tert-Butyl N-[(6R,7R)-7-hydroxy-1-(propan-2-yl)-2-azaspiro[3.4]octan-6-yl]carbamate2137434-41-2C15H28N2O3
- (6R,7R)-7-Amino-2-methyl-3-propan-2-yl-2-azaspiro[3.4]octan-6-ol2137434-35-4C11H22N2O
- 6,6-Difluoro-2-azaspiro[3.4]octane2306276-68-4C7H11F2N
- 5,5-Difluoro-2-azaspiro[3.4]octane2167201-55-8C7H11F2N
- 2-(2-(tert-Butoxycarbonyl)-2-azaspiro[3.4]octan-6-yl)acetic acid2206825-62-7C14H23NO4
- tert-Butyl trans-6-amino-7-hydroxy-2-azaspiro[3.4]octane-2-carboxylate2375164-73-9C12H22N2O3
- Methyl 6-methyl-2-azaspiro[3.4]octane-1-carboxylate2059935-58-7C10H17NO2
- Ethyl 2-azaspiro[3.4]octane-1-carboxylate2248266-83-1C10H17NO2
- tert-Butyl 5-amino-2-azaspiro[3.4]octane-2-carboxylate2169182-21-0C12H22N2O2
- tert-Butyl N-{2-azaspiro[3.4]octan-5-yl}carbamate2243505-93-1C12H22N2O2
- 2-(2-(tert-Butoxycarbonyl)-2-azaspiro[3.4]octan-5-yl)acetic acid2177267-05-7C14H23NO4
- tert-Butyl 5-amino-2-azaspiro[3.4]octane-2-carboxylate hydrochloride2177264-93-4C12H23ClN2O2
Related scaffolds
Same ring framework with different atoms or bond orders
C1CC2(C1)CCNC263 chemicals
C1CNC2(C1)CCC232 chemicals
C1COC2(C1)CNC230 chemicals
C1CCC2(C1)CCC229 chemicals
C1CC2(C1)CCOC218 chemicals
C1COC2(C1)CCC216 chemicals
C1CC2(CN1)CNC214 chemicals
C1CC2(CNC2)CO110 chemicals
C1CC2(CN1)COC210 chemicals
C1CC2(C1)OCCO28 chemicals
O=C1CC2(CNC2)CN17 chemicals
O=C1CC2(CCC2)CN17 chemicals