Murcko scaffold
Ring system with 2 rings and 8 atoms
52 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 8
- Chemicals
- 52
- With full pages
- 8
Scaffold SMILES
C1CC2(C1)OCCO2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 52 chemicals
![(6-Butyl-5,8-dioxaspiro[3.4]octan-2-yl)methanol chemical structure, C11H20O3, CAS 545882-64-2](/s/JZJFLVYCIGLUPQ-UHFFFAOYSA-N.svg)
(6-Butyl-5,8-dioxaspiro[3.4]octan-2-yl)methanol
CAS 545882-64-2C11H20O3
![5,8-Dioxaspiro[3.4]octane-2-methanol chemical structure, C7H12O3, CAS 545882-60-8](/s/LJVOOONKTBAYNA-UHFFFAOYSA-N.svg)
5,8-Dioxaspiro[3.4]octane-2-methanol
CAS 545882-60-8C7H12O3
![5,8-Dioxaspiro[3.4]octane, 6-butyl-2-(chloromethyl)- chemical structure, C11H19ClO2, CAS 654061-36-6](/s/HCOHCOVZPNRNON-UHFFFAOYSA-N.svg)
5,8-Dioxaspiro[3.4]octane, 6-butyl-2-(chloromethyl)-
CAS 654061-36-6C11H19ClO2
![1-Bromo-5,8-dioxaspiro[3.4]octane chemical structure, C6H9BrO2, CAS 20121-76-0](/s/UHURMISTHXXLOR-UHFFFAOYSA-N.svg)
1-Bromo-5,8-dioxaspiro[3.4]octane
CAS 20121-76-0C6H9BrO2
![5,8-Dioxaspiro[3.4]octane-2-carbonyl chloride chemical structure, C7H9ClO3, CAS 2568130-90-3](/s/UHVZWPKFVCLTAA-UHFFFAOYSA-N.svg)
5,8-Dioxaspiro[3.4]octane-2-carbonyl chloride
CAS 2568130-90-3C7H9ClO3
5,8-Dioxaspiro(3.4)octane-2-carboxylic acid
CAS 1001907-64-7C7H10O4
![5,8-Dioxaspiro[3.4]octan-6-ylmethanol chemical structure, C7H12O3, CAS 19837-63-9](/s/ZEPWVYWPLDSCKA-UHFFFAOYSA-N.svg)
5,8-Dioxaspiro[3.4]octan-6-ylmethanol
CAS 19837-63-9C7H12O3
![5,8-Dioxaspiro[3.4]octane-2-carbonitrile chemical structure, C7H9NO2, CAS 1432048-84-4](/s/CTQWSHDHUWTNHD-UHFFFAOYSA-N.svg)
5,8-Dioxaspiro[3.4]octane-2-carbonitrile
CAS 1432048-84-4C7H9NO2
![2-(Bromomethyl)-5,8-dioxaspiro[3.4]octane chemical structure, C7H11BrO2, CAS 1057641-71-0](/s/MKHPFTGDMWUGRW-UHFFFAOYSA-N.svg)
2-(Bromomethyl)-5,8-dioxaspiro[3.4]octane
CAS 1057641-71-0C7H11BrO2
![2-Bromo-5,8-dioxaspiro[3.4]octane chemical structure, C6H9BrO2, CAS 1257996-82-9](/s/ROJASEXNUCZUED-UHFFFAOYSA-N.svg)
2-Bromo-5,8-dioxaspiro[3.4]octane
CAS 1257996-82-9C6H9BrO2
![5,8-Dioxaspiro[3.4]octan-2-amine chemical structure, C6H11NO2, CAS 2387088-13-1](/s/YOQWTIXZKIMVHP-UHFFFAOYSA-N.svg)
5,8-Dioxaspiro[3.4]octan-2-amine
CAS 2387088-13-1C6H11NO2
![Methyl 5,8-dioxaspiro[3.4]octane-2-carboxylate chemical structure, C8H12O4, CAS 1037175-81-7](/s/BBIJGBVAQMCCEV-UHFFFAOYSA-N.svg)
Methyl 5,8-dioxaspiro[3.4]octane-2-carboxylate
CAS 1037175-81-7C8H12O4
![{5,8-Dioxaspiro[3.4]octan-2-yl}methanamine chemical structure, C7H13NO2, CAS 1392804-87-3](/s/LMLIBJBAFGAYBP-UHFFFAOYSA-N.svg)
{5,8-Dioxaspiro[3.4]octan-2-yl}methanamine
CAS 1392804-87-3C7H13NO2
2-Ethynyl-5,8-dioxaspiro(3.4)octane
CAS 1392803-25-6C8H10O2
![1-{5,8-Dioxaspiro[3.4]octan-6-yl}methanamine chemical structure, C7H13NO2, CAS 1546878-73-2](/s/BHBRSOAIBAVQRU-UHFFFAOYSA-N.svg)
1-{5,8-Dioxaspiro[3.4]octan-6-yl}methanamine
CAS 1546878-73-2C7H13NO2
![6-(Chloromethyl)-5,8-dioxaspiro[3.4]octane chemical structure, C7H11ClO2, CAS 1547416-59-0](/s/HAFAUXQYXKMRTP-UHFFFAOYSA-N.svg)
6-(Chloromethyl)-5,8-dioxaspiro[3.4]octane
CAS 1547416-59-0C7H11ClO2
![5,8-Dioxaspiro[3.4]octan-2-ylmethyl methanesulfonate chemical structure, C8H14O5S, CAS 1276654-97-7](/s/VOJNJMUVZSJEFY-UHFFFAOYSA-N.svg)
5,8-Dioxaspiro[3.4]octan-2-ylmethyl methanesulfonate
CAS 1276654-97-7C8H14O5S
![1-(5,8-Dioxaspiro[3.4]octan-2-yl)ethan-1-one chemical structure, C8H12O3, CAS 1823935-67-6](/s/ZWAPKWTYZVDSMN-UHFFFAOYSA-N.svg)
1-(5,8-Dioxaspiro[3.4]octan-2-yl)ethan-1-one
CAS 1823935-67-6C8H12O3
![[2-(Hydroxymethyl)-5,8-dioxaspiro[3.4]octan-2-yl]methanol chemical structure, C8H14O4, CAS 1788043-96-8](/s/SSIMJUSNVFTCGI-UHFFFAOYSA-N.svg)
[2-(Hydroxymethyl)-5,8-dioxaspiro[3.4]octan-2-yl]methanol
CAS 1788043-96-8C8H14O4
![1,1-Dimethyl-5,8-dioxaspiro[3.4]octane-2-carbaldehyde chemical structure, C9H14O3, CAS 1353586-67-0](/s/DVISZQJFCSJFPT-UHFFFAOYSA-N.svg)
1,1-Dimethyl-5,8-dioxaspiro[3.4]octane-2-carbaldehyde
CAS 1353586-67-0C9H14O3
![5,8-Dioxaspiro[3.4]octan-2-ol chemical structure, C6H10O3, CAS 1802988-78-8](/s/IDQGQAPNOMZNFC-UHFFFAOYSA-N.svg)
5,8-Dioxaspiro[3.4]octan-2-ol
CAS 1802988-78-8C6H10O3
![(2-Methyl-5,8-dioxaspiro[3.4]octan-2-yl)methanol chemical structure, C8H14O3, CAS 1638764-50-7](/s/JJUFHGLVRNMFQD-UHFFFAOYSA-N.svg)
(2-Methyl-5,8-dioxaspiro[3.4]octan-2-yl)methanol
CAS 1638764-50-7C8H14O3
![(1,1-Dimethyl-5,8-dioxaspiro[3.4]octan-2-yl)methanol chemical structure, C9H16O3, CAS 1353586-66-9](/s/USJMAMULBIDRRV-UHFFFAOYSA-N.svg)
(1,1-Dimethyl-5,8-dioxaspiro[3.4]octan-2-yl)methanol
CAS 1353586-66-9C9H16O3
![N-Methoxy-N-methyl-5,8-dioxaspiro[3.4]octane-2-carboxamide chemical structure, C9H15NO4, CAS 2098048-24-7](/s/OMEYEMMKPLPYGK-UHFFFAOYSA-N.svg)
N-Methoxy-N-methyl-5,8-dioxaspiro[3.4]octane-2-carboxamide
CAS 2098048-24-7C9H15NO4
- 5,8-Dioxaspiro(3.4)octane-2-carbaldehyde1936699-41-0C7H10O3
- 2-Amino-2-(5,8-dioxaspiro[3.4]octan-2-yl)acetic acid2097949-23-8C8H13NO4
- 2-((tert-Butoxycarbonyl)amino)-2-(5,8-dioxaspiro[3.4]octan-2-yl)acetic acid2097952-96-8C13H21NO6
- N-Methoxy-N-methyl-2-(5,8-dioxaspiro[3.4]octan-2-yl)acetamide2098068-31-4C10H17NO4
- 6-(Chloromethyl)-2,2-dimethyl-5,8-dioxaspiro[3.4]octane1935563-84-0C9H15ClO2
- 1-{2,2-Dimethyl-5,8-dioxaspiro[3.4]octan-6-yl}methanamine1935402-02-0C9H17NO2
- {2-Fluoro-5,8-dioxaspiro[3.4]octan-2-yl}methanamine2227204-93-3C7H12FNO2
- {2-Fluoro-5,8-dioxaspiro[3.4]octan-2-yl}methanol2227205-69-6C7H11FO3
- 2-Fluoro-5,8-dioxaspiro[3.4]octane-2-carboxylic acid2227204-92-2C7H9FO4
- 2-(Azidomethyl)-5,8-dioxaspiro[3.4]octane2095410-81-2C7H11N3O2
- 2-Methyl-5,8-dioxaspiro(3.4)octane-2-carbaldehyde2416236-43-4C8H12O3
- 5,8-Dioxaspiro[3.4]octane-2-thiol2580242-23-3C6H10O2S
- 5,8-Dioxaspiro[3.4]octane-2-sulfonyl chloride2580238-62-4C6H9ClO4S
- 6-(Bromomethyl)-2,2-bis(fluoromethyl)-5,8-dioxaspiro[3.4]octane2172476-49-0C9H13BrF2O2
- {2,2-Dimethyl-5,8-dioxaspiro[3.4]octan-6-yl}methyl methanesulfonate2172567-37-0C10H18O5S
- 6-(Bromomethyl)-5,8-dioxaspiro[3.4]octane2171989-13-0C7H11BrO2
- {2,2-Dimethyl-5,8-dioxaspiro[3.4]octan-6-yl}methanol2172020-12-9C9H16O3
- 6-(Bromomethyl)-2,2-dimethyl-5,8-dioxaspiro[3.4]octane2172014-71-8C9H15BrO2
- {5,8-Dioxaspiro[3.4]octan-6-yl}methyl methanesulfonate2171883-61-5C8H14O5S
- 5,8-Dioxaspiro[3.4]octane-2-sulfonamide2639457-94-4C6H11NO4S
- 5,8-Dioxaspiro[3.4]octane-2-sulfonyl fluoride2648948-87-0C6H9FO4S
- 2-(Methoxymethyl)-5,8-dioxaspiro(3.4)octan-2-amine hydrochloride2866352-35-2C8H16ClNO3
- 2-(Methoxymethyl)-5,8-dioxaspiro[3.4]octan-2-amine2770517-72-9C8H15NO3
- 2-(Methoxymethyl)-5,8-dioxaspiro[3.4]octane-2-carboxylic acid2866308-25-8C9H14O5
Related scaffolds
Same ring framework with different atoms or bond orders
C1CC2(C1)CCNC263 chemicals
C1CNC2(C1)CCC232 chemicals
C1COC2(C1)CNC230 chemicals
C1CCC2(C1)CCC229 chemicals
C1CC2(C1)CCOC218 chemicals
C1COC2(C1)CCC216 chemicals
C1CCC2(C1)CNC215 chemicals
C1CC2(CN1)CNC214 chemicals
C1CC2(CNC2)CO110 chemicals
C1CC2(CN1)COC210 chemicals
O=C1CC2(CNC2)CN17 chemicals
O=C1CC2(CCC2)CN17 chemicals