Murcko scaffold
2-Oxa-6-azaspiro[3.4]octane scaffold
117 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 8
- Chemicals
- 117
- With full pages
- 10
Scaffold SMILES
C1CC2(CN1)COC2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 117 chemicals
![2-Oxa-6-azaspiro[3.4]octane chemical structure, C6H11NO, CAS 220290-68-6](/s/ZHAIMJRKJKQNQI-UHFFFAOYSA-N.svg)
2-Oxa-6-azaspiro[3.4]octane
CAS 220290-68-6C6H11NO
![6-Boc-2-oxa-6-azaspiro[3.4]octane chemical structure, C11H19NO3, CAS 1245816-31-2](/s/ACMASIMZBDTNIZ-UHFFFAOYSA-N.svg)
6-Boc-2-oxa-6-azaspiro[3.4]octane
CAS 1245816-31-2C11H19NO3
![6-Isopropyl-2-oxa-6-azaspiro[3.4]octane chemical structure, C9H17NO, CAS 1824060-46-9](/s/RGQREBJTGPWOPJ-UHFFFAOYSA-N.svg)
6-Isopropyl-2-oxa-6-azaspiro[3.4]octane
CAS 1824060-46-9C9H17NO
![tert-Butyl 2-oxa-6-azaspiro[3.4]octan-8-ylcarbamate chemical structure, C11H20N2O3, CAS 1422496-61-4](/s/XRGGCKIYCRHBHJ-UHFFFAOYSA-N.svg)
tert-Butyl 2-oxa-6-azaspiro[3.4]octan-8-ylcarbamate
CAS 1422496-61-4C11H20N2O3
![2-Oxa-6-azaspiro[3.4]octane oxalate chemical structure, C8H13NO5, CAS 1408075-00-2](/s/BCXRHUMGWMWGLN-UHFFFAOYSA-N.svg)
2-Oxa-6-azaspiro[3.4]octane oxalate
CAS 1408075-00-2C8H13NO5
![Acetamide, 2,2,2-trifluoro-N-2-oxa-6-azaspiro[3.4]oct-8-yl- chemical structure, C8H11F3N2O2, CAS 219869-31-5](/s/NZOYVYYUOWPHHX-UHFFFAOYSA-N.svg)
Acetamide, 2,2,2-trifluoro-N-2-oxa-6-azaspiro[3.4]oct-8-yl-
CAS 219869-31-5C8H11F3N2O2
![2,2,2-Trifluoro-N-methyl-N-(2-oxa-7-azaspiro[3.4]octan-5-yl)acetamide chemical structure, C9H13F3N2O2, CAS 219869-46-2](/s/VNBZZBGUVGWNQL-UHFFFAOYSA-N.svg)
2,2,2-Trifluoro-N-methyl-N-(2-oxa-7-azaspiro[3.4]octan-5-yl)acetamide
CAS 219869-46-2C9H13F3N2O2
![tert-Butyl 5-amino-2-oxa-7-azaspiro[3.4]octane-7-carboxylate chemical structure, C11H20N2O3, CAS 1369347-56-7](/s/WQPAFNUAEVKJRO-UHFFFAOYSA-N.svg)
tert-Butyl 5-amino-2-oxa-7-azaspiro[3.4]octane-7-carboxylate
CAS 1369347-56-7C11H20N2O3
![2-Oxa-6-azaspiro[3.4]octane hemioxalate chemical structure, C14H24N2O6, CAS 1523570-96-8](/s/DREVFFJHSWBTQS-UHFFFAOYSA-N.svg)
2-Oxa-6-azaspiro[3.4]octane hemioxalate
CAS 1523570-96-8C14H24N2O6
![2-Oxa-6-azaspiro[3.4]octan-8-amine chemical structure, C6H12N2O, CAS 2137565-82-1](/s/YXMFSCZBFPTGOP-UHFFFAOYSA-N.svg)
2-Oxa-6-azaspiro[3.4]octan-8-amine
CAS 2137565-82-1C6H12N2O
![1-{2-Oxa-6-azaspiro[3.4]octan-8-yl}methanamine chemical structure, C7H14N2O, CAS 1581684-24-3](/s/QLLFATZSGSBYRI-UHFFFAOYSA-N.svg)
1-{2-Oxa-6-azaspiro[3.4]octan-8-yl}methanamine
CAS 1581684-24-3C7H14N2O
![1-(2-Oxa-6-azaspiro[3.4]octan-6-yl)ethanone chemical structure, C8H13NO2, CAS 1824275-63-9](/s/JQCJLAWFXBIZCN-UHFFFAOYSA-N.svg)
1-(2-Oxa-6-azaspiro[3.4]octan-6-yl)ethanone
CAS 1824275-63-9C8H13NO2
![tert-Butyl (5R)-5-amino-2-oxa-7-azaspiro[3.4]octane-7-carboxylate chemical structure, C11H20N2O3, CAS 2920232-60-4](/s/WQPAFNUAEVKJRO-QMMMGPOBSA-N.svg)
tert-Butyl (5R)-5-amino-2-oxa-7-azaspiro[3.4]octane-7-carboxylate
CAS 2920232-60-4C11H20N2O3
![tert-Butyl (5S)-5-amino-2-oxa-7-azaspiro[3.4]octane-7-carboxylate chemical structure, C11H20N2O3, CAS 2920239-57-0](/s/WQPAFNUAEVKJRO-MRVPVSSYSA-N.svg)
tert-Butyl (5S)-5-amino-2-oxa-7-azaspiro[3.4]octane-7-carboxylate
CAS 2920239-57-0C11H20N2O3
![2-Oxa-6-azaspiro[3.4]octan-6-amine chemical structure, C6H12N2O, CAS 2830114-73-1](/s/YZMCWMSDHWUCBY-UHFFFAOYSA-N.svg)
2-Oxa-6-azaspiro[3.4]octan-6-amine
CAS 2830114-73-1C6H12N2O
![8-Methyl-2-oxa-6-azaspiro[3.4]octane chemical structure, C7H13NO, CAS 2110933-59-8](/s/WHLLAPISYZBZNI-UHFFFAOYSA-N.svg)
8-Methyl-2-oxa-6-azaspiro[3.4]octane
CAS 2110933-59-8C7H13NO
![6-[(tert-Butoxy)carbonyl]-2-oxa-6-azaspiro[3.4]octane-8-carboxylic acid chemical structure, C12H19NO5, CAS 1803608-20-9](/s/KOEYCRLDXMOAJA-UHFFFAOYSA-N.svg)
6-[(tert-Butoxy)carbonyl]-2-oxa-6-azaspiro[3.4]octane-8-carboxylic acid
CAS 1803608-20-9C12H19NO5
![Ethyl 8-fluoro-2-oxa-6-azaspiro[3.4]octane-8-carboxylate hydrochloride chemical structure, C9H15ClFNO3, CAS 1803585-70-7](/s/SMVNVGQDGFXPKG-UHFFFAOYSA-N.svg)
Ethyl 8-fluoro-2-oxa-6-azaspiro[3.4]octane-8-carboxylate hydrochloride
CAS 1803585-70-7C9H15ClFNO3
![Ethyl 8-fluoro-2-oxa-6-azaspiro[3.4]octane-8-carboxylate chemical structure, C9H14FNO3, CAS 1312325-32-8](/s/MHZSLMPGYBWUSE-UHFFFAOYSA-N.svg)
Ethyl 8-fluoro-2-oxa-6-azaspiro[3.4]octane-8-carboxylate
CAS 1312325-32-8C9H14FNO3
6-((tert-Butoxy)carbonyl)-8-fluoro-2-oxa-6-azaspiro(3.4)octane-8-carboxylic acid
CAS 1312411-21-4C12H18FNO5
![Ethyl 2-oxa-6-azaspiro[3.4]octane-8-carboxylate hydrochloride chemical structure, C9H16ClNO3, CAS 1820741-76-1](/s/DVBPINLPCHOULO-UHFFFAOYSA-N.svg)
Ethyl 2-oxa-6-azaspiro[3.4]octane-8-carboxylate hydrochloride
CAS 1820741-76-1C9H16ClNO3
![Ethyl 2-oxa-6-azaspiro[3.4]octane-8-carboxylate chemical structure, C9H15NO3, CAS 1312325-23-7](/s/QCQPYEGWJXOVLA-UHFFFAOYSA-N.svg)
Ethyl 2-oxa-6-azaspiro[3.4]octane-8-carboxylate
CAS 1312325-23-7C9H15NO3
![(2-Oxa-6-aza-spiro[3.4]oct-8-ylmethyl)-carbamic acid tert-butyl ester chemical structure, C12H22N2O3, CAS 1312325-17-9](/s/GYKWVGBRKUFDKG-UHFFFAOYSA-N.svg)
(2-Oxa-6-aza-spiro[3.4]oct-8-ylmethyl)-carbamic acid tert-butyl ester
CAS 1312325-17-9C12H22N2O3
![8-Fluoro-2-oxa-6-azaspiro[3.4]octane-8-carboxylic acid hydrochloride chemical structure, C7H11ClFNO3, CAS 1955554-37-6](/s/FESWSZFHTYTCIC-UHFFFAOYSA-N.svg)
8-Fluoro-2-oxa-6-azaspiro[3.4]octane-8-carboxylic acid hydrochloride
CAS 1955554-37-6C7H11ClFNO3
- 8-Fluoro-2-oxa-6-azaspiro[3.4]octane-8-carboxylic acid1936661-81-2C7H10FNO3
- Potassium 6-[(tert-butoxy)carbonyl]-2-oxa-6-azaspiro[3.4]octane-8-carboxylate1823778-98-8C12H18KNO5
- Potassium 6-(tert-butoxycarbonyl)-8-fluoro-2-oxa-6-azaspiro[3.4]octane-8-carboxylate1312325-29-3C12H17FKNO5
- Ethyl 8-fluoro-2-oxa-6-azaspiro[3.4]octane-8-carboxylate hemioxalate1955560-51-6C20H30F2N2O10
- Bis(ethyl 2-oxa-6-azaspiro[3.4]octane-8-carboxylate), oxalic acid1955514-99-4C20H32N2O10
- (8-Fluoro-2-oxa-6-azaspiro(3.4)octan-8-yl)methanol1824632-51-0C7H12FNO2
- (5R)-5-Fluoro-2-oxa-7-azaspiro[3.4]octane-5-carboxylic acid2920197-25-5C7H10FNO3
- (5S)-5-Fluoro-2-oxa-7-azaspiro[3.4]octane-5-carboxylic acid2920239-71-8C7H10FNO3
- (5R)-7-tert-Butoxycarbonyl-2-oxa-7-azaspiro[3.4]octane-5-carboxylic acid2920428-08-4C12H19NO5
- (5S)-7-tert-Butoxycarbonyl-2-oxa-7-azaspiro[3.4]octane-5-carboxylic acid2920196-83-2C12H19NO5
- (5S)-7-tert-Butoxycarbonyl-5-fluoro-2-oxa-7-azaspiro[3.4]octane-5-carboxylic acid2920178-41-0C12H18FNO5
- tert-Butyl N-[(5S)-2-oxa-7-azaspiro[3.4]octan-5-yl]carbamate2674032-75-6C11H20N2O3
- tert-Butyl N-[(5R)-2-oxa-7-azaspiro[3.4]octan-5-yl]carbamate2512199-84-5C11H20N2O3
- tert-Butyl 8-fluoro-8-(hydroxymethyl)-2-oxa-6-azaspiro[3.4]octane-6-carboxylate1823228-96-1C12H20FNO4
- 2-(2-Oxa-6-azaspiro[3.4]octan-6-yl)acetic acid1824275-71-9C8H13NO3
- 2-(2-Oxa-6-azaspiro[3.4]octan-6-yl)ethanol1824066-52-5C8H15NO2
- 2-(2-Oxa-6-azaspiro[3.4]octan-6-yl)ethanamine1822675-63-7C8H16N2O
- 2-Chloro-1-(2-oxa-6-azaspiro[3.4]octan-6-yl)ethanone1823250-26-5C8H12ClNO2
- 2-Amino-1-(2-oxa-6-azaspiro[3.4]octan-6-yl)propan-1-one1822545-47-0C9H16N2O2
- Methyl 2-oxa-6-azaspiro[3.4]octane-8-carboxylate1934548-31-8C8H13NO3
- 6-Acetyl-2-oxa-6-azaspiro[3.4]octane-8-carboxylic acid1936563-12-0C9H13NO4
- tert-Butyl (R)-8-(hydroxymethyl)-2-oxa-6-azaspiro[3.4]octane-6-carboxylate1932499-84-7C12H21NO4
- tert-Butyl 8-(hydroxymethyl)-2-oxa-6-azaspiro[3.4]octane-6-carboxylate1934949-83-3C12H21NO4
- Methyl 8-fluoro-2-oxa-6-azaspiro[3.4]octane-8-carboxylate1935389-05-1C8H12FNO3
Related scaffolds
Same ring framework with different atoms or bond orders
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C1CCC2(C1)CCC229 chemicals
C1CC2(C1)CCOC218 chemicals
C1COC2(C1)CCC216 chemicals
C1CCC2(C1)CNC215 chemicals
C1CC2(CN1)CNC214 chemicals
C1CC2(CNC2)CO110 chemicals
C1CC2(C1)OCCO28 chemicals
O=C1CC2(CNC2)CN17 chemicals
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