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Murcko scaffold

Spiro(3.4)octane scaffold

164 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
8
Chemicals
164
With full pages
29
Scaffold SMILES

C1CCC2(C1)CCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Spiro(3.4)octane page
Murcko scaffold C1CCC2(C1)CCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 164 chemicals

Spiro(3.4)octane chemical structure, C8H14, CAS 175-56-4
Spiro(3.4)octane
CAS 175-56-4C8H14
2-Ethoxyspiro[3.4]octane-1,1-dicarbonitrile chemical structure, C12H16N2O, CAS 887574-92-7
2-Ethoxyspiro[3.4]octane-1,1-dicarbonitrile
CAS 887574-92-7C12H16N2O
3-Amino-6,7-dimethylspiro[3.4]octane-1-carboxylic acid chemical structure, C11H19NO2, CAS 251461-90-2
3-Amino-6,7-dimethylspiro[3.4]octane-1-carboxylic acid
CAS 251461-90-2C11H19NO2
Spiro(3.4)octane-2-carboxylic acid chemical structure, C9H14O2, CAS 18386-63-5
Spiro(3.4)octane-2-carboxylic acid
CAS 18386-63-5C9H14O2
Spiro[3.4]octane-2-carbonyl chloride chemical structure, C9H13ClO, CAS 91329-41-8
Spiro[3.4]octane-2-carbonyl chloride
CAS 91329-41-8C9H13ClO
6,6-Dimethylspiro[3.4]octan-5-ol chemical structure, C10H18O, CAS 820222-45-5
6,6-Dimethylspiro[3.4]octan-5-ol
CAS 820222-45-5C10H18O
3-Ethoxy-N-methylspiro[3.4]octan-1-amine hydrochloride chemical structure, C11H22ClNO, CAS 1333616-84-4
3-Ethoxy-N-methylspiro[3.4]octan-1-amine hydrochloride
CAS 1333616-84-4C11H22ClNO
3-Ethoxy-N-methylspiro[3.4]octan-1-amine chemical structure, C11H21NO, CAS 1334101-80-2
3-Ethoxy-N-methylspiro[3.4]octan-1-amine
CAS 1334101-80-2C11H21NO
3-Ethoxy-N-propylspiro[3.4]octan-1-amine hydrochloride chemical structure, C13H26ClNO, CAS 1333847-63-4
3-Ethoxy-N-propylspiro[3.4]octan-1-amine hydrochloride
CAS 1333847-63-4C13H26ClNO
3-Ethoxy-N-propylspiro[3.4]octan-1-amine chemical structure, C13H25NO, CAS 1334102-61-2
3-Ethoxy-N-propylspiro[3.4]octan-1-amine
CAS 1334102-61-2C13H25NO
3-Ethoxyspiro[3.4]octan-1-ol chemical structure, C10H18O2, CAS 1334149-61-9
3-Ethoxyspiro[3.4]octan-1-ol
CAS 1334149-61-9C10H18O2
3-Ethoxyspiro(3.4)octan-1-amine chemical structure, C10H19NO, CAS 1342130-96-4
3-Ethoxyspiro(3.4)octan-1-amine
CAS 1342130-96-4C10H19NO
Spiro(3.4)octan-5-amine chemical structure, C8H15N, CAS 61888-97-9
Spiro(3.4)octan-5-amine
CAS 61888-97-9C8H15N
Spiro[3.4]octan-6-ol chemical structure, C8H14O, CAS 960587-81-9
Spiro[3.4]octan-6-ol
CAS 960587-81-9C8H14O
{Spiro[3.4]octan-6-yl}methanol chemical structure, C9H16O, CAS 1147732-89-5
{Spiro[3.4]octan-6-yl}methanol
CAS 1147732-89-5C9H16O
Spiro[3.4]octane-6-carbaldehyde chemical structure, C9H14O, CAS 2920155-48-0
Spiro[3.4]octane-6-carbaldehyde
CAS 2920155-48-0C9H14O
Spiro[3.4]octan-2-ylmethanamine chemical structure, C9H17N, CAS 1496060-20-8
Spiro[3.4]octan-2-ylmethanamine
CAS 1496060-20-8C9H17N
N-Methyl-1-(spiro[3.4]octan-2-yl)methanamine chemical structure, C10H19N, CAS 1484803-15-7
N-Methyl-1-(spiro[3.4]octan-2-yl)methanamine
CAS 1484803-15-7C10H19N
N-(Spiro[3.4]octan-2-ylmethyl)ethanamine chemical structure, C11H21N, CAS 1491188-73-8
N-(Spiro[3.4]octan-2-ylmethyl)ethanamine
CAS 1491188-73-8C11H21N
N-(Spiro[3.4]octan-2-ylmethyl)propan-2-amine chemical structure, C12H23N, CAS 1490202-97-5
N-(Spiro[3.4]octan-2-ylmethyl)propan-2-amine
CAS 1490202-97-5C12H23N
2-(Aminomethyl)spiro[3.4]octane-2-carboxylic acid chemical structure, C10H17NO2, CAS 1479377-87-1
2-(Aminomethyl)spiro[3.4]octane-2-carboxylic acid
CAS 1479377-87-1C10H17NO2
2-Methanesulfonylspiro[3.4]octane-2-carboxylic acid chemical structure, C10H16O4S, CAS 1465413-77-7
2-Methanesulfonylspiro[3.4]octane-2-carboxylic acid
CAS 1465413-77-7C10H16O4S
Methyl 2-(aminomethyl)spiro[3.4]octane-2-carboxylate chemical structure, C11H19NO2, CAS 1491179-71-5
Methyl 2-(aminomethyl)spiro[3.4]octane-2-carboxylate
CAS 1491179-71-5C11H19NO2
Ethyl 2-(aminomethyl)spiro[3.4]octane-2-carboxylate chemical structure, C12H21NO2, CAS 1495330-47-6
Ethyl 2-(aminomethyl)spiro[3.4]octane-2-carboxylate
CAS 1495330-47-6C12H21NO2