Murcko scaffold
5-Oxa-2-azaspiro[3.4]octane scaffold
159 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 8
- Chemicals
- 159
- With full pages
- 30
Scaffold SMILES
C1COC2(C1)CNC2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 159 chemicals
![5-Oxa-2-azaspiro[3.4]octane chemical structure, C6H11NO, CAS 145309-24-6](/s/NRPURYORSRHBCU-UHFFFAOYSA-N.svg)
5-Oxa-2-azaspiro[3.4]octane
CAS 145309-24-6C6H11NO
![7-Fluoro-5-oxa-2-azaspiro[3.4]octane chemical structure, C6H10FNO, CAS 1214875-48-5](/s/KGPIPXGDPCYQKA-UHFFFAOYSA-N.svg)
7-Fluoro-5-oxa-2-azaspiro[3.4]octane
CAS 1214875-48-5C6H10FNO
![7,7-Difluoro-5-oxa-2-azaspiro[3.4]octane chemical structure, C6H9F2NO, CAS 1214875-26-9](/s/GJAUUPPAJTVUHL-UHFFFAOYSA-N.svg)
7,7-Difluoro-5-oxa-2-azaspiro[3.4]octane
CAS 1214875-26-9C6H9F2NO
![tert-Butyl 5-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C11H19NO3, CAS 1935464-53-1](/s/CLNLROLNWMTWCK-UHFFFAOYSA-N.svg)
tert-Butyl 5-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 1935464-53-1C11H19NO3
tert-Butyl 7-bromo-5-oxa-2-azaspiro(3.4)octane-2-carboxylate
CAS 1330765-30-4C11H18BrNO3
2-(tert-Butoxycarbonyl)-5-oxa-2-azaspiro(3.4)octane-7-carboxylic acid
CAS 1251009-46-7C12H19NO5
2-((tert-Butoxy)carbonyl)-5-oxa-2-azaspiro(3.4)octane-6-carboxylic acid
CAS 1251006-00-4C12H19NO5
tert-Butyl 7-cyano-5-oxa-2-azaspiro(3.4)octane-2-carboxylate
CAS 1330763-36-4C12H18N2O3
![5-Oxa-2-azaspiro[3.4]octane oxalate chemical structure, C8H13NO5, CAS 2108852-98-6](/s/DMERACGZTKROAB-UHFFFAOYSA-N.svg)
5-Oxa-2-azaspiro[3.4]octane oxalate
CAS 2108852-98-6C8H13NO5
![tert-Butyl 6-(hydroxymethyl)-5-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H21NO4, CAS 1446012-48-1](/s/IQPBJPYNUXVTEC-UHFFFAOYSA-N.svg)
tert-Butyl 6-(hydroxymethyl)-5-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 1446012-48-1C12H21NO4
![tert-Butyl 6-formyl-5-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C12H19NO4, CAS 1446012-49-2](/s/XOEAGCZCFMXJRF-UHFFFAOYSA-N.svg)
tert-Butyl 6-formyl-5-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 1446012-49-2C12H19NO4
5-Oxa-2-azaspiro(3.4)octane-2-carboxylic acid, 8-amino-, 1,1-dimethylethyl ester
CAS 1408074-44-1C11H20N2O3
![tert-Butyl 7-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C11H19NO4, CAS 1408074-46-3](/s/PWCXTAYTSYDZTN-UHFFFAOYSA-N.svg)
tert-Butyl 7-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 1408074-46-3C11H19NO4
![5-Oxa-2-azaspiro[3.4]octane hydrochloride chemical structure, C6H12ClNO, CAS 1359656-11-3](/s/RVTZXQHPQGYYGT-UHFFFAOYSA-N.svg)
5-Oxa-2-azaspiro[3.4]octane hydrochloride
CAS 1359656-11-3C6H12ClNO
![5-Oxa-2-aza-spiro[3.4]octane hemioxalate chemical structure, C14H24N2O6, CAS 1523618-29-2](/s/OZSFCICIMABNNL-UHFFFAOYSA-N.svg)
5-Oxa-2-aza-spiro[3.4]octane hemioxalate
CAS 1523618-29-2C14H24N2O6
5-Oxa-2-azaspiro(3.4)octan-7-ol hydrochloride
CAS 1613292-50-4C6H12ClNO2
![5-Oxa-2-azaspiro[3.4]octan-7-ol chemical structure, C6H11NO2, CAS 1613363-18-0](/s/BBXJOPXVHFPVDD-UHFFFAOYSA-N.svg)
5-Oxa-2-azaspiro[3.4]octan-7-ol
CAS 1613363-18-0C6H11NO2
tert-Butyl 7-(hydroxymethyl)-5-oxa-2-azaspiro(3.4)octane-2-carboxylate
CAS 1330764-06-1C12H21NO4
![tert-Butyl (R)-8-amino-5-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C11H20N2O3, CAS 2198241-64-2](/s/LSACGXFQGVBFLY-MRVPVSSYSA-N.svg)
tert-Butyl (R)-8-amino-5-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 2198241-64-2C11H20N2O3
![tert-Butyl (S)-8-amino-5-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C11H20N2O3, CAS 2306246-50-2](/s/LSACGXFQGVBFLY-QMMMGPOBSA-N.svg)
tert-Butyl (S)-8-amino-5-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 2306246-50-2C11H20N2O3
![tert-Butyl (7S)-7-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C11H19NO4, CAS 2165563-31-3](/s/PWCXTAYTSYDZTN-QMMMGPOBSA-N.svg)
tert-Butyl (7S)-7-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 2165563-31-3C11H19NO4
![tert-Butyl (7R)-7-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C11H19NO4, CAS 1453316-08-9](/s/PWCXTAYTSYDZTN-MRVPVSSYSA-N.svg)
tert-Butyl (7R)-7-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 1453316-08-9C11H19NO4
![tert-Butyl (8S)-8-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C11H19NO4, CAS 2306248-79-1](/s/AUOIOKGLSQZUQZ-QMMMGPOBSA-N.svg)
tert-Butyl (8S)-8-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 2306248-79-1C11H19NO4
![tert-Butyl (8R)-8-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate chemical structure, C11H19NO4, CAS 2200580-52-3](/s/AUOIOKGLSQZUQZ-MRVPVSSYSA-N.svg)
tert-Butyl (8R)-8-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate
CAS 2200580-52-3C11H19NO4
- 2-[(7S)-2-[(tert-Butoxy)carbonyl]-5-oxa-2-azaspiro[3.4]octan-7-yl]acetic acid2199282-33-0C13H21NO5
- 2-[(7R)-2-[(tert-Butoxy)carbonyl]-5-oxa-2-azaspiro[3.4]octan-7-yl]acetic acid2381710-98-9C13H21NO5
- tert-Butyl (7R)-7-amino-5-oxa-2-azaspiro[3.4]octane-2-carboxylate2165837-31-8C11H20N2O3
- tert-Butyl (7S)-7-amino-5-oxa-2-azaspiro[3.4]octane-2-carboxylate1453316-10-3C11H20N2O3
- tert-Butyl 7-amino-5-oxa-2-azaspiro[3.4]octane-2-carboxylate1250998-24-3C11H20N2O3
- 1-(Propan-2-yl)-5-oxa-2-azaspiro[3.4]octane1820618-88-9C9H17NO
- tert-Butyl 7-(aminomethyl)-5-oxa-2-azaspiro[3.4]octane-2-carboxylate1330765-27-9C12H22N2O3
- tert-Butyl 8-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate1453315-99-5C11H19NO4
- tert-Butyl 8-(2-aminoethyl)-5-oxa-2-azaspiro[3.4]octane-2-carboxylate1823417-57-7C13H24N2O3
- tert-Butyl 8-(2-hydroxyethyl)-5-oxa-2-azaspiro[3.4]octane-2-carboxylate1823776-19-7C13H23NO4
- tert-Butyl 6-(iodomethyl)-5-oxa-2-azaspiro(3.4)octane-2-carboxylate1638771-46-6C12H20INO3
- tert-Butyl 6-(aminomethyl)-5-oxa-2-azaspiro[3.4]octane-2-carboxylate1251022-86-2C12H22N2O3
- Methyl 5-oxa-2-azaspiro[3.4]octane-7-carboxylate2219374-19-1C8H13NO3
- 2-(2-(tert-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]octan-7-yl)acetic acid1330763-34-2C13H21NO5
- tert-Butyl (7S)-7-(2-aminoethyl)-5-oxa-2-azaspiro[3.4]octane-2-carboxylate2382501-92-8C13H24N2O3
- tert-Butyl (7R)-7-(2-aminoethyl)-5-oxa-2-azaspiro[3.4]octane-2-carboxylate2199389-33-6C13H24N2O3
- 3-(2-(tert-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]octan-7-yl)propanoic acid2382653-67-8C13H23NO4
- tert-Butyl (7R)-7-(2-hydroxyethyl)-5-oxa-2-azaspiro[3.4]octane-2-carboxylate2200580-65-8C13H23NO4
- tert-Butyl 7-(2-hydroxyethyl)-5-oxa-2-azaspiro[3.4]octane-2-carboxylate1330763-92-2C13H23NO4
- tert-Butyl 7-(2-aminoethyl)-5-oxa-2-azaspiro[3.4]octane-2-carboxylate1330764-09-4C13H24N2O3
- 7-Methyl-5-oxa-2-azaspiro[3.4]octane2306260-93-3C7H13NO
- tert-Butyl N-methyl-N-{5-oxa-2-azaspiro[3.4]octan-7-yl}carbamate2089669-64-5C12H22N2O3
- 7,7-Difluoro-5-oxa-2-azaspiro[3.4]octane hydrochloride2177267-06-8C6H10ClF2NO
- tert-Butyl 8-(hydroxymethyl)-5-oxa-2-azaspiro[3.4]octane-2-carboxylate2122197-01-5C12H21NO4
Related scaffolds
Same ring framework with different atoms or bond orders
C1CC2(C1)CCNC263 chemicals
C1CNC2(C1)CCC232 chemicals
C1CCC2(C1)CCC229 chemicals
C1CC2(C1)CCOC218 chemicals
C1COC2(C1)CCC216 chemicals
C1CCC2(C1)CNC215 chemicals
C1CC2(CN1)CNC214 chemicals
C1CC2(CNC2)CO110 chemicals
C1CC2(CN1)COC210 chemicals
C1CC2(C1)OCCO28 chemicals
O=C1CC2(CNC2)CN17 chemicals
O=C1CC2(CCC2)CN17 chemicals