Murcko scaffold
Ring system with 2 rings and 8 atoms
112 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 8
- Chemicals
- 112
- With full pages
- 16
Scaffold SMILES
C1COC2(C1)CCC2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 112 chemicals
![5-Oxaspiro[3.4]octane-2-carboxylic acid chemical structure, C8H12O3, CAS 1374658-88-4](/s/IKQYNEIRTGISNQ-UHFFFAOYSA-N.svg)
5-Oxaspiro[3.4]octane-2-carboxylic acid
CAS 1374658-88-4C8H12O3
![5-Oxaspiro[3.4]octan-2-amine chemical structure, C7H13NO, CAS 1374659-16-1](/s/MNSBKXZGNNQYBX-UHFFFAOYSA-N.svg)
5-Oxaspiro[3.4]octan-2-amine
CAS 1374659-16-1C7H13NO
![3-Ethoxy-5-oxaspiro[3.4]octan-1-amine hydrochloride chemical structure, C9H18ClNO2, CAS 1461704-62-0](/s/JNXDENNRAMRJHK-UHFFFAOYSA-N.svg)
3-Ethoxy-5-oxaspiro[3.4]octan-1-amine hydrochloride
CAS 1461704-62-0C9H18ClNO2
![3-Ethoxy-5-oxaspiro[3.4]octan-1-amine chemical structure, C9H17NO2, CAS 1461868-71-2](/s/VXTSEPDCQOGHJA-UHFFFAOYSA-N.svg)
3-Ethoxy-5-oxaspiro[3.4]octan-1-amine
CAS 1461868-71-2C9H17NO2
![5-Oxaspiro[3.4]octan-1-amine chemical structure, C7H13NO, CAS 1824254-30-9](/s/AMKJJZLBASTVPA-UHFFFAOYSA-N.svg)
5-Oxaspiro[3.4]octan-1-amine
CAS 1824254-30-9C7H13NO
![5-Oxaspiro[3.4]octan-7-amine hydrochloride chemical structure, C7H14ClNO, CAS 1955557-50-2](/s/AGSMDKBDFWEGLX-UHFFFAOYSA-N.svg)
5-Oxaspiro[3.4]octan-7-amine hydrochloride
CAS 1955557-50-2C7H14ClNO
5-Oxaspiro(3.4)octan-7-amine
CAS 1823901-45-6C7H13NO
![{5-Oxaspiro[3.4]octan-6-yl}methanamine hydrochloride chemical structure, C8H16ClNO, CAS 2089255-97-8](/s/VXYWNLKAEKEQFZ-UHFFFAOYSA-N.svg)
{5-Oxaspiro[3.4]octan-6-yl}methanamine hydrochloride
CAS 2089255-97-8C8H16ClNO
![{5-Oxaspiro[3.4]octan-6-yl}methanamine chemical structure, C8H15NO, CAS 1849240-49-8](/s/UEXFOKAUQHQTAU-UHFFFAOYSA-N.svg)
{5-Oxaspiro[3.4]octan-6-yl}methanamine
CAS 1849240-49-8C8H15NO
6-(Iodomethyl)-5-oxaspiro(3.4)octane
CAS 1849359-21-2C8H13IO
![Methyl({5-oxaspiro[3.4]octan-6-yl}methyl)amine chemical structure, C9H17NO, CAS 1849352-87-9](/s/SFYVVTPUALZDMG-UHFFFAOYSA-N.svg)
Methyl({5-oxaspiro[3.4]octan-6-yl}methyl)amine
CAS 1849352-87-9C9H17NO
![{5-Oxaspiro[3.4]octan-6-yl}methanol chemical structure, C8H14O2, CAS 1849275-00-8](/s/CBXKPNPYASHFKP-UHFFFAOYSA-N.svg)
{5-Oxaspiro[3.4]octan-6-yl}methanol
CAS 1849275-00-8C8H14O2
![5-Oxaspiro[3.4]octane-6-carbaldehyde chemical structure, C8H12O2, CAS 1880817-17-3](/s/QDMPHGGFUWGDAS-UHFFFAOYSA-N.svg)
5-Oxaspiro[3.4]octane-6-carbaldehyde
CAS 1880817-17-3C8H12O2
![5-Oxaspiro[3.4]octane-6-carboxylic acid chemical structure, C8H12O3, CAS 1866738-51-3](/s/DZYBZRGUTMNZEK-UHFFFAOYSA-N.svg)
5-Oxaspiro[3.4]octane-6-carboxylic acid
CAS 1866738-51-3C8H12O3
![2-{5-Oxaspiro[3.4]octan-6-yl}ethan-1-amine chemical structure, C9H17NO, CAS 1849371-61-4](/s/WXJJPWGLEPNVCT-UHFFFAOYSA-N.svg)
2-{5-Oxaspiro[3.4]octan-6-yl}ethan-1-amine
CAS 1849371-61-4C9H17NO
![2-{5-Oxaspiro[3.4]octan-6-yl}acetic acid chemical structure, C9H14O3, CAS 2092599-28-3](/s/MAWUMCVBJWHYSB-UHFFFAOYSA-N.svg)
2-{5-Oxaspiro[3.4]octan-6-yl}acetic acid
CAS 2092599-28-3C9H14O3
tert-Butyl 6-(aminomethyl)-5-oxaspiro(3.4)octane-2-carboxylate
CAS 2126177-92-0C13H23NO3
(5-Oxaspiro(3.4)octan-6-yl)methanesulfonyl chloride
CAS 2137854-82-9C8H13ClO3S
![{5-Oxaspiro[3.4]octan-7-yl}methanamine chemical structure, C8H15NO, CAS 2306276-33-3](/s/KTCYAXRENJHNGP-UHFFFAOYSA-N.svg)
{5-Oxaspiro[3.4]octan-7-yl}methanamine
CAS 2306276-33-3C8H15NO
![{5-Oxaspiro[3.4]octan-7-yl}methanol chemical structure, C8H14O2, CAS 2306275-60-3](/s/MQEVNJGAJHVBPR-UHFFFAOYSA-N.svg)
{5-Oxaspiro[3.4]octan-7-yl}methanol
CAS 2306275-60-3C8H14O2
![5-Oxaspiro[3.4]octan-7-ol chemical structure, C7H12O2, CAS 2022120-79-0](/s/MOPMSOKOYUCNMC-UHFFFAOYSA-N.svg)
5-Oxaspiro[3.4]octan-7-ol
CAS 2022120-79-0C7H12O2
![(2R)-2-{5-Oxaspiro[3.4]octan-6-yl}propanoic acid chemical structure, C10H16O3, CAS 2248220-08-6](/s/HGDXJFFELGMDIK-GVHYBUMESA-N.svg)
(2R)-2-{5-Oxaspiro[3.4]octan-6-yl}propanoic acid
CAS 2248220-08-6C10H16O3
![(1R)-1-{5-Oxaspiro[3.4]octan-6-yl}ethan-1-amine chemical structure, C9H17NO, CAS 2248212-60-2](/s/JKNFCVGYOQMNMV-GVHYBUMESA-N.svg)
(1R)-1-{5-Oxaspiro[3.4]octan-6-yl}ethan-1-amine
CAS 2248212-60-2C9H17NO
![2-{5-Oxaspiro[3.4]octan-6-yl}propanoic acid chemical structure, C10H16O3, CAS 2248295-98-7](/s/HGDXJFFELGMDIK-UHFFFAOYSA-N.svg)
2-{5-Oxaspiro[3.4]octan-6-yl}propanoic acid
CAS 2248295-98-7C10H16O3
- (2S)-2-{5-Oxaspiro[3.4]octan-6-yl}propanoic acid2248215-14-5C10H16O3
- 2-{5-Oxaspiro[3.4]octan-6-yl}propan-1-ol2248273-62-1C10H18O2
- (2S)-2-{5-Oxaspiro[3.4]octan-6-yl}propan-1-ol2248215-52-1C10H18O2
- (2S)-2-{5-Oxaspiro[3.4]octan-6-yl}propan-1-amine2248220-27-9C10H19NO
- 1-{5-Oxaspiro[3.4]octan-6-yl}ethan-1-amine2248343-17-9C9H17NO
- (2R)-2-{5-Oxaspiro[3.4]octan-6-yl}propan-1-amine2248216-97-7C10H19NO
- (2R)-2-{5-Oxaspiro[3.4]octan-6-yl}propan-1-ol2248215-79-2C10H18O2
- 2-{5-Oxaspiro[3.4]octan-6-yl}propan-1-amine2248412-08-8C10H19NO
- (1S)-1-{5-Oxaspiro[3.4]octan-6-yl}ethan-1-amine2248213-76-3C9H17NO
- 5-Oxaspiro[3.4]octan-1-amine hydrochloride2309444-38-8C7H14ClNO
- 5-Oxaspiro(3.4)octane-1-carboxylic acid2309467-97-6C8H12O3
- {5-Oxaspiro[3.4]octan-1-yl}methanamine hydrochloride2344685-32-9C8H16ClNO
- 1-{5-Oxaspiro[3.4]octan-1-yl}methanamine2344681-19-0C8H15NO
- N-(3-Ethoxy-5-oxaspiro[3.4]octan-1-yl)prop-2-enamide2387158-85-0C12H19NO3
- 2-Bromo-1-(5-oxaspiro[3.4]octan-2-yl)ethanone2413885-17-1C9H13BrO2
- (E)-4-(Dimethylamino)-N-(3-ethoxy-5-oxaspiro[3.4]octan-1-yl)but-2-enamide2411324-76-8C15H26N2O3
- N-(3-Ethoxy-5-oxaspiro[3.4]octan-1-yl)but-2-ynamide2411193-95-6C13H19NO3
- 2-Chloro-N-(3-ethoxy-5-oxaspiro[3.4]octan-1-yl)acetamide2411193-34-3C11H18ClNO3
- tert-Butyl 6-(iodomethyl)-5-oxaspiro[3.4]octane-2-carboxylate2416236-80-9C13H21IO3
- (7R,8S)-7-Amino-5-oxaspiro[3.4]octan-8-ol, hydrochloride2752066-45-6C7H14ClNO2
- rac-(7R,8S)-7-Amino-5-oxaspiro[3.4]octan-8-ol2445750-51-4C7H13NO2
- (7S,8R)-8-Methoxy-5-oxaspiro[3.4]octan-7-amine, hydrochloride2470279-80-0C8H16ClNO2
- 6-({[(tert-Butoxy)carbonyl]amino}methyl)-5-oxaspiro[3.4]octane-2-carboxylicacid,Mixtureofdiastereomers2385087-00-1C14H23NO5
- 2-(2-((tert-Butoxy)carbonyl)-5-oxaspiro(3.4)octan-6-yl)acetic acid2567504-37-2C14H22O5
Related scaffolds
Same ring framework with different atoms or bond orders
C1CC2(C1)CCNC263 chemicals
C1CNC2(C1)CCC232 chemicals
C1COC2(C1)CNC230 chemicals
C1CCC2(C1)CCC229 chemicals
C1CC2(C1)CCOC218 chemicals
C1CCC2(C1)CNC215 chemicals
C1CC2(CN1)CNC214 chemicals
C1CC2(CNC2)CO110 chemicals
C1CC2(CN1)COC210 chemicals
C1CC2(C1)OCCO28 chemicals
O=C1CC2(CNC2)CN17 chemicals
O=C1CC2(CCC2)CN17 chemicals