Murcko scaffold
6-Aza-spiro[3.4]octane scaffold
474 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 8
- Chemicals
- 474
- With full pages
- 63
Scaffold SMILES
C1CC2(C1)CCNC2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 474 chemicals
![tert-Butyl (S)-(6-azaspiro[3.4]octan-8-yl)carbamate chemical structure, C12H22N2O2, CAS 154295-25-7](/s/HKOSEKNVWYWWGV-SECBINFHSA-N.svg)
tert-Butyl (S)-(6-azaspiro[3.4]octan-8-yl)carbamate
CAS 154295-25-7C12H22N2O2
![tert-Butyl (R)-(6-azaspiro[3.4]octan-8-yl)carbamate chemical structure, C12H22N2O2, CAS 154295-23-5](/s/HKOSEKNVWYWWGV-VIFPVBQESA-N.svg)
tert-Butyl (R)-(6-azaspiro[3.4]octan-8-yl)carbamate
CAS 154295-23-5C12H22N2O2
![tert-Butyl N-{6-azaspiro[3.4]octan-8-yl}carbamate chemical structure, C12H22N2O2, CAS 1258649-89-6](/s/HKOSEKNVWYWWGV-UHFFFAOYSA-N.svg)
tert-Butyl N-{6-azaspiro[3.4]octan-8-yl}carbamate
CAS 1258649-89-6C12H22N2O2
![6-Azaspiro[3.4]octan-8-amine chemical structure, C7H14N2, CAS 2138282-93-4](/s/QDGNJINXGBPBDN-UHFFFAOYSA-N.svg)
6-Azaspiro[3.4]octan-8-amine
CAS 2138282-93-4C7H14N2
![6-Aza-spiro[3.4]octane chemical structure, C7H13N, CAS 765-64-0](/s/NVZWMJWMTWOVNJ-UHFFFAOYSA-N.svg)
6-Aza-spiro[3.4]octane
CAS 765-64-0C7H13N
![tert-Butyl 8-(hydroxymethyl)-6-azaspiro[3.4]octane-6-carboxylate chemical structure, C13H23NO3, CAS 129321-82-0](/s/UTVLESWQVLBCDG-UHFFFAOYSA-N.svg)
tert-Butyl 8-(hydroxymethyl)-6-azaspiro[3.4]octane-6-carboxylate
CAS 129321-82-0C13H23NO3
![tert-Butyl 2-(2-ethoxy-2-oxoethyl)-6-azaspiro[3.4]octane-6-carboxylate chemical structure, C16H27NO4, CAS 203662-33-3](/s/DKBUBVVHVOHQCI-UHFFFAOYSA-N.svg)
tert-Butyl 2-(2-ethoxy-2-oxoethyl)-6-azaspiro[3.4]octane-6-carboxylate
CAS 203662-33-3C16H27NO4
![tert-Butyl 2-formyl-6-azaspiro[3.4]octane-6-carboxylate chemical structure, C13H21NO3, CAS 203662-55-9](/s/AQNPHZHLJTXPKM-UHFFFAOYSA-N.svg)
tert-Butyl 2-formyl-6-azaspiro[3.4]octane-6-carboxylate
CAS 203662-55-9C13H21NO3
![tert-Butyl 2-(hydroxymethyl)-6-azaspiro[3.4]octane-6-carboxylate chemical structure, C13H23NO3, CAS 203662-48-0](/s/NADWHBFAGOIEAE-UHFFFAOYSA-N.svg)
tert-Butyl 2-(hydroxymethyl)-6-azaspiro[3.4]octane-6-carboxylate
CAS 203662-48-0C13H23NO3
![6-tert-Butyl 2-methyl 6-azaspiro[3.4]octane-2,6-dicarboxylate chemical structure, C14H23NO4, CAS 203662-61-7](/s/USXOUCHGCDBQPX-UHFFFAOYSA-N.svg)
6-tert-Butyl 2-methyl 6-azaspiro[3.4]octane-2,6-dicarboxylate
CAS 203662-61-7C14H23NO4
![tert-Butyl 1-amino-3-ethoxy-6-azaspiro[3.4]octane-6-carboxylate chemical structure, C14H26N2O3, CAS 1354961-70-8](/s/MTYMMSZJEKTXTN-UHFFFAOYSA-N.svg)
tert-Butyl 1-amino-3-ethoxy-6-azaspiro[3.4]octane-6-carboxylate
CAS 1354961-70-8C14H26N2O3
![tert-Butyl 2-cyano-6-azaspiro[3.4]octane-6-carboxylate chemical structure, C13H20N2O2, CAS 1239319-99-3](/s/RKRWQMWHGXWXSV-UHFFFAOYSA-N.svg)
tert-Butyl 2-cyano-6-azaspiro[3.4]octane-6-carboxylate
CAS 1239319-99-3C13H20N2O2
![6-[(tert-Butoxy)carbonyl]-6-azaspiro[3.4]octane-2-carboxylic acid chemical structure, C13H21NO4, CAS 1251002-42-2](/s/QLUYLNWFJLLXOV-UHFFFAOYSA-N.svg)
6-[(tert-Butoxy)carbonyl]-6-azaspiro[3.4]octane-2-carboxylic acid
CAS 1251002-42-2C13H21NO4
![tert-Butyl 2-amino-6-azaspiro[3.4]octane-6-carboxylate chemical structure, C12H22N2O2, CAS 1239319-94-8](/s/TWNDWKDXPSDFLL-UHFFFAOYSA-N.svg)
tert-Butyl 2-amino-6-azaspiro[3.4]octane-6-carboxylate
CAS 1239319-94-8C12H22N2O2
![Ethyl (S)-2,2-difluoro-6-azaspiro[3.4]octane-7-carboxylate chemical structure, C10H15F2NO2, CAS 1272656-72-0](/s/HCXOCMFNPKSBJC-ZETCQYMHSA-N.svg)
Ethyl (S)-2,2-difluoro-6-azaspiro[3.4]octane-7-carboxylate
CAS 1272656-72-0C10H15F2NO2
![Ethyl 2-[tert-butyl(dimethyl)silyl]oxy-6-azaspiro[3.4]octane-7-carboxylate chemical structure, C16H31NO3Si, CAS 1272656-60-6](/s/XYCLLMNRQMDDAH-UHFFFAOYSA-N.svg)
Ethyl 2-[tert-butyl(dimethyl)silyl]oxy-6-azaspiro[3.4]octane-7-carboxylate
CAS 1272656-60-6C16H31NO3Si
![6-Methyl-6-azaspiro[3.4]octan-8-amine chemical structure, C8H16N2, CAS 1545012-04-1](/s/NGCFZCCDKVGZHZ-UHFFFAOYSA-N.svg)
6-Methyl-6-azaspiro[3.4]octan-8-amine
CAS 1545012-04-1C8H16N2
![(7R)-7-Methyl-6-azaspiro[3.4]octane chemical structure, C8H15N, CAS 2382365-66-2](/s/LXZYDFHXZDFHAN-SSDOTTSWSA-N.svg)
(7R)-7-Methyl-6-azaspiro[3.4]octane
CAS 2382365-66-2C8H15N
![tert-Butyl 2-(aminomethyl)-6-azaspiro[3.4]octane-6-carboxylate chemical structure, C13H24N2O2, CAS 1239320-01-4](/s/ULVSOOBGBSFHJO-UHFFFAOYSA-N.svg)
tert-Butyl 2-(aminomethyl)-6-azaspiro[3.4]octane-6-carboxylate
CAS 1239320-01-4C13H24N2O2
![7-Methyl-6-azaspiro[3.4]octane chemical structure, C8H15N, CAS 1804129-24-5](/s/LXZYDFHXZDFHAN-UHFFFAOYSA-N.svg)
7-Methyl-6-azaspiro[3.4]octane
CAS 1804129-24-5C8H15N
tert-Butyl 2-hydroxy-6-azaspiro(3.4)octane-6-carboxylate
CAS 1239319-91-5C12H21NO3
![2-(Boc-amino)-6-aza-spiro[3.4]octane chemical structure, C12H22N2O2, CAS 1341038-64-9](/s/RBGFMICDKNOJBB-UHFFFAOYSA-N.svg)
2-(Boc-amino)-6-aza-spiro[3.4]octane
CAS 1341038-64-9C12H22N2O2
![6-Aza-spiro[3.4]octane oxalate chemical structure, C9H15NO4, CAS 1706451-40-2](/s/SVFZHRQWKBJNND-UHFFFAOYSA-N.svg)
6-Aza-spiro[3.4]octane oxalate
CAS 1706451-40-2C9H15NO4
![tert-Butyl 1-hydroxy-6-azaspiro[3.4]octane-6-carboxylate chemical structure, C12H21NO3, CAS 1341039-44-8](/s/XVJZTDDYLWCINU-UHFFFAOYSA-N.svg)
tert-Butyl 1-hydroxy-6-azaspiro[3.4]octane-6-carboxylate
CAS 1341039-44-8C12H21NO3
- tert-Butyl 1-amino-6-azaspiro[3.4]octane-6-carboxylate1251010-30-6C12H22N2O2
- 6-Acetyl-6-azaspiro[3.4]octane-2-carboxylic acid1420816-64-3C10H15NO3
- 1-(2-(Bromomethyl)-6-azaspiro[3.4]octan-6-yl)ethanone1420836-10-7C10H16BrNO
- 1-(2-(Chloromethyl)-6-azaspiro[3.4]octan-6-yl)ethanone1420958-99-1C10H16ClNO
- 1-(2-(Aminomethyl)-6-azaspiro[3.4]octan-6-yl)ethanone1420842-62-1C10H18N2O
- 1-(2-(Hydroxymethyl)-6-azaspiro[3.4]octan-6-yl)ethanone1420883-52-8C10H17NO2
- 1-(2-(Mercaptomethyl)-6-azaspiro[3.4]octan-6-yl)ethanone1420842-09-6C10H17NOS
- 1-(2-Amino-6-azaspiro[3.4]octan-6-yl)ethanone1420891-66-2C9H16N2O
- tert-Butyl 2-(bromomethyl)-6-azaspiro[3.4]octane-6-carboxylate1420959-11-0C13H22BrNO2
- tert-Butyl 2-(chloromethyl)-6-azaspiro[3.4]octane-6-carboxylate1420958-87-7C13H22ClNO2
- tert-Butyl 2-(mercaptomethyl)-6-azaspiro[3.4]octane-6-carboxylate1420854-17-6C13H23NO2S
- 6-(2-Amino-3-methylbutanoyl)-6-azaspiro[3.4]octane-2-carboxylic acid1420788-75-5C13H22N2O3
- 2-Amino-1-(2-(bromomethyl)-6-azaspiro[3.4]octan-6-yl)-3-methylbutan-1-one1420795-36-3C13H23BrN2O
- 2-Amino-1-(2-(chloromethyl)-6-azaspiro[3.4]octan-6-yl)-3-methylbutan-1-one1420786-17-9C13H23ClN2O
- 2-Amino-1-(2-(aminomethyl)-6-azaspiro[3.4]octan-6-yl)-3-methylbutan-1-one1420785-60-9C13H25N3O
- 2-Amino-1-(2-(hydroxymethyl)-6-azaspiro[3.4]octan-6-yl)-3-methylbutan-1-one1420795-72-7C13H24N2O2
- 2-Amino-1-(2-(mercaptomethyl)-6-azaspiro[3.4]octan-6-yl)-3-methylbutan-1-one1420784-51-5C13H24N2OS
- 2-Amino-1-(2-amino-6-azaspiro[3.4]octan-6-yl)-3-methylbutan-1-one1420795-81-8C12H23N3O
- 6-Isopropyl-6-azaspiro[3.4]octane-2-carboxylic acid1420816-69-8C11H19NO2
- 2-(Bromomethyl)-6-isopropyl-6-azaspiro[3.4]octane1420965-99-6C11H20BrN
- 2-(Chloromethyl)-6-isopropyl-6-azaspiro[3.4]octane1420903-43-0C11H20ClN
- (6-Isopropyl-6-azaspiro[3.4]octan-2-yl)methanamine1420966-28-4C11H22N2
- (6-Isopropyl-6-azaspiro[3.4]octan-2-yl)methanol1420958-63-9C11H21NO
- (6-Isopropyl-6-azaspiro[3.4]octan-2-yl)methanethiol1420849-72-4C11H21NS
Related scaffolds
Same ring framework with different atoms or bond orders
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