Murcko scaffold
2,5-Diazaspiro[3.4]octan-1-one scaffold
22 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 9
- Chemicals
- 22
- With full pages
- 1
Scaffold SMILES
O=C1NCC12CCCN2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 22 of 22 chemicals
![2,5-Diazaspiro[3.4]octan-1-one chemical structure, C6H10N2O, CAS 1031928-32-1](/s/PJSRRPBVTJKYEP-UHFFFAOYSA-N.svg)
2,5-Diazaspiro[3.4]octan-1-one
CAS 1031928-32-1C6H10N2O
![2,5-Diazaspiro[3.4]octane-5-carboxylic acid, 2-[2-(methylamino)-2-oxoethyl]-1-oxo-, methyl ester, (4R)- chemical structure, C11H17N3O4, CAS 914389-29-0](/s/ZWAQKPDRZRTMMS-LLVKDONJSA-N.svg)
2,5-Diazaspiro[3.4]octane-5-carboxylic acid, 2-[2-(methylamino)-2-oxoethyl]-1-oxo-, methyl ester, (4R)-
CAS 914389-29-0C11H17N3O4
![(2S,3R)-2-(5-(tert-Butoxycarbonyl)-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)-3-hydroxybutanoic acid chemical structure, C15H24N2O6, CAS 1621435-15-1](/s/IQPWGJWLDXLEMF-ODLMARSHSA-N.svg)
(2S,3R)-2-(5-(tert-Butoxycarbonyl)-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)-3-hydroxybutanoic acid
CAS 1621435-15-1C15H24N2O6
![(2S)-2-(5-(tert-Butoxycarbonyl)-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)-3-hydroxypropanoic acid chemical structure, C14H22N2O6, CAS 1621435-34-4](/s/NSXFJOYCHHTIAN-CUVJYRNJSA-N.svg)
(2S)-2-(5-(tert-Butoxycarbonyl)-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)-3-hydroxypropanoic acid
CAS 1621435-34-4C14H22N2O6
![(2S,3R)-2-(5-(tert-Butoxycarbonyl)-6-methyl-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)-3-hydroxybutanoic acid chemical structure, C16H26N2O6, CAS 1621435-47-9](/s/BZUQACJLLPPLPJ-OUBLUOKUSA-N.svg)
(2S,3R)-2-(5-(tert-Butoxycarbonyl)-6-methyl-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)-3-hydroxybutanoic acid
CAS 1621435-47-9C16H26N2O6
![(2S,3R)-2-(5-(tert-Butoxycarbonyl)-1-methyl-3-oxo-2,5-diazaspiro[3.4]octan-2-yl)-3-hydroxybutanoic acid chemical structure, C16H26N2O6, CAS 1621435-39-9](/s/PJBZPAMGWWPWCP-BNJSKVTLSA-N.svg)
(2S,3R)-2-(5-(tert-Butoxycarbonyl)-1-methyl-3-oxo-2,5-diazaspiro[3.4]octan-2-yl)-3-hydroxybutanoic acid
CAS 1621435-39-9C16H26N2O6
Nyx-2925
CAS 2012536-16-0C14H23N3O4
Risevistinel
CAS 2591344-26-0C14H23N3O4
![(2S,3R)-2-((S)-5-(tert-Butoxycarbonyl)-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)-3-hydroxybutanoic acid chemical structure, C15H24N2O6, CAS 2151842-63-4](/s/IQPWGJWLDXLEMF-FTGAXOIBSA-N.svg)
(2S,3R)-2-((S)-5-(tert-Butoxycarbonyl)-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)-3-hydroxybutanoic acid
CAS 2151842-63-4C15H24N2O6
![(2S,3R)-2-((R)-5-(tert-Butoxycarbonyl)-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)-3-hydroxybutanoic acid chemical structure, C15H24N2O6, CAS 2151842-51-0](/s/IQPWGJWLDXLEMF-HFBDOXOYSA-N.svg)
(2S,3R)-2-((R)-5-(tert-Butoxycarbonyl)-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)-3-hydroxybutanoic acid
CAS 2151842-51-0C15H24N2O6
Zelquistinel
CAS 2151842-64-5C15H25N3O5
![5-Methyl-1-oxo-2,5-diazaspiro[3.4]octane-6-carboxylic acid chemical structure, C8H12N2O3, CAS 2182592-83-0](/s/DWMSDBMHINRCMO-UHFFFAOYSA-N.svg)
5-Methyl-1-oxo-2,5-diazaspiro[3.4]octane-6-carboxylic acid
CAS 2182592-83-0C8H12N2O3
![tert-Butyl 7-hydroxy-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate chemical structure, C11H18N2O4, CAS 2306260-79-5](/s/OZQYBMKBCYPPFL-UHFFFAOYSA-N.svg)
tert-Butyl 7-hydroxy-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate
CAS 2306260-79-5C11H18N2O4
![2,5-Diazaspiro[3.4]octan-1-one hydrochloride chemical structure, C6H11ClN2O, CAS 1329504-00-8](/s/KVAKULOBNOADJS-UHFFFAOYSA-N.svg)
2,5-Diazaspiro[3.4]octan-1-one hydrochloride
CAS 1329504-00-8C6H11ClN2O
![1-Oxo-2,5-diazaspiro[3.4]octane-6-carboxylic acid chemical structure, C7H10N2O3, CAS 2306260-99-9](/s/XKISJVIJHTZNQO-UHFFFAOYSA-N.svg)
1-Oxo-2,5-diazaspiro[3.4]octane-6-carboxylic acid
CAS 2306260-99-9C7H10N2O3
![tert-Butyl 7-cyano-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate chemical structure, C12H17N3O3, CAS 2306261-07-2](/s/QHTMZASODYZVCX-UHFFFAOYSA-N.svg)
tert-Butyl 7-cyano-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate
CAS 2306261-07-2C12H17N3O3
![tert-Butyl (7S)-7-hydroxy-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate chemical structure, C11H18N2O4, CAS 2375172-61-3](/s/OZQYBMKBCYPPFL-RGENBBCFSA-N.svg)
tert-Butyl (7S)-7-hydroxy-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate
CAS 2375172-61-3C11H18N2O4
![tert-Butyl (7R)-7-cyano-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate chemical structure, C12H17N3O3, CAS 2306259-63-0](/s/QHTMZASODYZVCX-KBPLZSHQSA-N.svg)
tert-Butyl (7R)-7-cyano-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate
CAS 2306259-63-0C12H17N3O3
NYX-2925 monohydrate
CAS 2641992-17-6C14H25N3O5
![5-tert-Butoxycarbonyl-3-oxo-2,5-diazaspiro[3.4]octane-7-carboxylic acid chemical structure, C12H18N2O5, CAS 2306263-19-2](/s/WDRDDVZGYQSBKT-UHFFFAOYSA-N.svg)
5-tert-Butoxycarbonyl-3-oxo-2,5-diazaspiro[3.4]octane-7-carboxylic acid
CAS 2306263-19-2C12H18N2O5
![tert-Butyl (7R)-7-hydroxy-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate chemical structure, C11H18N2O4, CAS 2375172-52-2](/s/OZQYBMKBCYPPFL-DKSCNQEISA-N.svg)
tert-Butyl (7R)-7-hydroxy-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate
CAS 2375172-52-2C11H18N2O4
![tert-Butyl (7S)-7-cyano-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate chemical structure, C12H17N3O3, CAS 2306259-49-2](/s/QHTMZASODYZVCX-SZSXPDSJSA-N.svg)
tert-Butyl (7S)-7-cyano-3-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate
CAS 2306259-49-2C12H17N3O3
Related scaffolds
Same ring framework with different atoms or bond orders
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C1CCC2(C1)CCC229 chemicals
C1CC2(C1)CCOC218 chemicals
C1COC2(C1)CCC216 chemicals
C1CCC2(C1)CNC215 chemicals
C1CC2(CN1)CNC214 chemicals
C1CC2(CNC2)CO110 chemicals
C1CC2(CN1)COC210 chemicals
C1CC2(C1)OCCO28 chemicals
O=C1CC2(CNC2)CN17 chemicals