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Murcko scaffold

1-Benzyl-4-(pyridin-2-ylmethyl)piperazine scaffold

76 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
76
With full pages
4
Scaffold SMILES

c1ccc(CN2CCN(Cc3ccccn3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Benzyl-4-(pyridin-2-ylmethyl)piperazine page
Murcko scaffold c1ccc(CN2CCN(Cc3ccccn3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 76 chemicals

1-[(3-Nitrophenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine chemical structure, C17H20N4O2, CAS 428835-49-8
1-[(3-Nitrophenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine
CAS 428835-49-8C17H20N4O2
1-(2-Chlorobenzyl)-4-(pyridin-2-ylmethyl)piperazine chemical structure, C17H20ClN3, CAS 423745-81-7
1-(2-Chlorobenzyl)-4-(pyridin-2-ylmethyl)piperazine
CAS 423745-81-7C17H20ClN3
1-[(3-Ethoxy-4-methoxy-phenyl)methyl]-4-(pyridin-2-ylmethyl)-2,3,5,6-tetrahydropyrazine chemical structure, C20H27N3O2, CAS 6713-26-4
1-[(3-Ethoxy-4-methoxy-phenyl)methyl]-4-(pyridin-2-ylmethyl)-2,3,5,6-tetrahydropyrazine
CAS 6713-26-4C20H27N3O2
1-[(4-Bromophenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine chemical structure, C17H20BrN3, CAS 5979-16-8
1-[(4-Bromophenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine
CAS 5979-16-8C17H20BrN3
1-(4-Chlorobenzyl)-4-(pyridin-2-ylmethyl)piperazine chemical structure, C17H20ClN3, CAS 505050-87-3
1-(4-Chlorobenzyl)-4-(pyridin-2-ylmethyl)piperazine
CAS 505050-87-3C17H20ClN3
1-[(2-Fluorophenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine chemical structure, C17H20FN3, CAS 462098-89-1
1-[(2-Fluorophenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine
CAS 462098-89-1C17H20FN3
1-[(3,4-Dimethoxyphenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine chemical structure, C19H25N3O2, CAS 428829-08-7
1-[(3,4-Dimethoxyphenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine
CAS 428829-08-7C19H25N3O2
1-(4-Ethylbenzyl)-4-(pyridin-2-ylmethyl)piperazine chemical structure, C19H25N3, CAS 500001-80-9
1-(4-Ethylbenzyl)-4-(pyridin-2-ylmethyl)piperazine
CAS 500001-80-9C19H25N3
1-[(4-Fluorophenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine chemical structure, C17H20FN3, CAS 428834-63-3
1-[(4-Fluorophenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine
CAS 428834-63-3C17H20FN3
1-Benzyl-4-(pyridin-2-ylmethyl)piperazine chemical structure, C17H21N3, CAS 266674-67-3
1-Benzyl-4-(pyridin-2-ylmethyl)piperazine
CAS 266674-67-3C17H21N3
1-[(2-Methoxyphenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine chemical structure, C18H23N3O, CAS 423738-18-5
1-[(2-Methoxyphenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine
CAS 423738-18-5C18H23N3O
1-[(4-Methoxyphenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine chemical structure, C18H23N3O, CAS 423745-10-2
1-[(4-Methoxyphenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine
CAS 423745-10-2C18H23N3O
1-[(4-Methylphenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine chemical structure, C18H23N3, CAS 423742-75-0
1-[(4-Methylphenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine
CAS 423742-75-0C18H23N3
1-(Pyridin-2-ylmethyl)-4-[2-(trifluoromethyl)benzyl]piperazine chemical structure, C18H20F3N3, CAS 492429-73-9
1-(Pyridin-2-ylmethyl)-4-[2-(trifluoromethyl)benzyl]piperazine
CAS 492429-73-9C18H20F3N3
1-(3-Fluorobenzyl)-4-(pyridin-2-ylmethyl)piperazine chemical structure, C17H20FN3, CAS 423745-82-8
1-(3-Fluorobenzyl)-4-(pyridin-2-ylmethyl)piperazine
CAS 423745-82-8C17H20FN3
1-[(4-Ethoxyphenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine chemical structure, C19H25N3O, CAS 462602-70-6
1-[(4-Ethoxyphenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine
CAS 462602-70-6C19H25N3O
1-[4-(Methylsulfanyl)benzyl]-4-(pyridin-2-ylmethyl)piperazine chemical structure, C18H23N3S, CAS 461403-29-2
1-[4-(Methylsulfanyl)benzyl]-4-(pyridin-2-ylmethyl)piperazine
CAS 461403-29-2C18H23N3S
1-(2,3-Dimethoxybenzyl)-4-(pyridin-2-ylmethyl)piperazine chemical structure, C19H25N3O2, CAS 423746-59-2
1-(2,3-Dimethoxybenzyl)-4-(pyridin-2-ylmethyl)piperazine
CAS 423746-59-2C19H25N3O2
1-[(2-Bromophenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine chemical structure, C17H20BrN3, CAS 423742-32-9
1-[(2-Bromophenyl)methyl]-4-(pyridin-2-ylmethyl)piperazine
CAS 423742-32-9C17H20BrN3
1-(3-Bromobenzyl)-4-(pyridin-2-ylmethyl)piperazine chemical structure, C17H20BrN3, CAS 423752-89-0
1-(3-Bromobenzyl)-4-(pyridin-2-ylmethyl)piperazine
CAS 423752-89-0C17H20BrN3
1-(Pyridin-2-ylmethyl)-4-[(2,4,5-trimethoxyphenyl)methyl]piperazine chemical structure, C20H27N3O3, CAS 353773-06-5
1-(Pyridin-2-ylmethyl)-4-[(2,4,5-trimethoxyphenyl)methyl]piperazine
CAS 353773-06-5C20H27N3O3
1-(Pyridin-2-ylmethyl)-4-[(3,4,5-trimethoxyphenyl)methyl]piperazine chemical structure, C20H27N3O3, CAS 423744-76-7
1-(Pyridin-2-ylmethyl)-4-[(3,4,5-trimethoxyphenyl)methyl]piperazine
CAS 423744-76-7C20H27N3O3
1-(5-Bromo-2-methoxybenzyl)-4-(pyridin-2-ylmethyl)piperazine chemical structure, C18H22BrN3O, CAS 423750-06-5
1-(5-Bromo-2-methoxybenzyl)-4-(pyridin-2-ylmethyl)piperazine
CAS 423750-06-5C18H22BrN3O
1-(Pyridin-2-ylmethyl)-4-(2,3,4-trimethoxybenzyl)piperazine chemical structure, C20H27N3O3, CAS 423747-92-6
1-(Pyridin-2-ylmethyl)-4-(2,3,4-trimethoxybenzyl)piperazine
CAS 423747-92-6C20H27N3O3