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Murcko scaffold

N-Phenethyl-2,3-dihydro-1,4-benzodioxine-2-carboxamide scaffold

10 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
10
With full pages
4
Scaffold SMILES

O=C(NCCc1ccccc1)C1COc2ccccc2O1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-Phenethyl-2,3-dihydro-1,4-benzodioxine-2-carboxamide page
Murcko scaffold O=C(NCCc1ccccc1)C1COc2ccccc2O1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

N-[2-(3,4-Dimethoxyphenyl)ethyl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide chemical structure, C19H21NO5, CAS 304888-40-2
N-[2-(3,4-Dimethoxyphenyl)ethyl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide
CAS 304888-40-2C19H21NO5
N-Phenethyl-2,3-dihydro-1,4-benzodioxine-2-carboxamide chemical structure, C17H17NO3, CAS 304888-44-6
N-Phenethyl-2,3-dihydro-1,4-benzodioxine-2-carboxamide
CAS 304888-44-6C17H17NO3
N-(1-Phenylpropan-2-yl)-2,3-dihydro-1,4-benzodioxine-3-carboxamide chemical structure, C18H19NO3, CAS 331964-70-6
N-(1-Phenylpropan-2-yl)-2,3-dihydro-1,4-benzodioxine-3-carboxamide
CAS 331964-70-6C18H19NO3
N-[2-(4-Sulfamoylphenyl)ethyl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide chemical structure, C17H18N2O5S, CAS 686726-48-7
N-[2-(4-Sulfamoylphenyl)ethyl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide
CAS 686726-48-7C17H18N2O5S
N-[2-(4-Chlorophenyl)ethyl]-2,3-dihydro-1,4-benzodioxine-3-carboxamide chemical structure, C17H16ClNO3, CAS 761417-37-2
N-[2-(4-Chlorophenyl)ethyl]-2,3-dihydro-1,4-benzodioxine-3-carboxamide
CAS 761417-37-2C17H16ClNO3
N-(3,3,3-Trifluoro-2-hydroxy-2-phenylpropyl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide chemical structure, C18H16F3NO4, CAS 1351613-60-9
N-(3,3,3-Trifluoro-2-hydroxy-2-phenylpropyl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide
CAS 1351613-60-9C18H16F3NO4
N-(2-Hydroxy-2-(4-(methylthio)phenyl)ethyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C18H19NO4S, CAS 1448129-24-5
N-(2-Hydroxy-2-(4-(methylthio)phenyl)ethyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS 1448129-24-5C18H19NO4S
N-[2-(2-Fluorophenyl)-2-methoxypropyl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide chemical structure, C19H20FNO4, CAS 1797558-81-6
N-[2-(2-Fluorophenyl)-2-methoxypropyl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide
CAS 1797558-81-6C19H20FNO4
N-(2-Methoxy-2-phenylbutyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C20H23NO4, CAS 1798039-42-5
N-(2-Methoxy-2-phenylbutyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS 1798039-42-5C20H23NO4
N-(2-(3-Chlorophenyl)-2-methoxypropyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide chemical structure, C19H20ClNO4, CAS 1798544-83-8
N-(2-(3-Chlorophenyl)-2-methoxypropyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS 1798544-83-8C19H20ClNO4