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Murcko scaffold

Ring system with 3 rings and 23 atoms

26 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
26
With full pages
3
Scaffold SMILES

O=C(COc1ccccc1)Nc1c[nH]n(-c2ccccc2)c1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COc1ccccc1)Nc1c[nH]n(-c2ccccc2)c1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-phenoxyacetamide chemical structure, C19H19N3O3, CAS 3985-34-0
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-phenoxyacetamide
CAS 3985-34-0C19H19N3O3
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(2-methoxyphenoxy)acetamide chemical structure, C20H21N3O4, CAS 65537-16-8
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(2-methoxyphenoxy)acetamide
CAS 65537-16-8C20H21N3O4
2-(2,4-Dichlorophenoxy)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide chemical structure, C19H17Cl2N3O3, CAS 65537-10-2
2-(2,4-Dichlorophenoxy)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide
CAS 65537-10-2C19H17Cl2N3O3
2-(4-Chlorophenoxy)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide chemical structure, C19H18ClN3O3, CAS 33145-71-0
2-(4-Chlorophenoxy)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide
CAS 33145-71-0C19H18ClN3O3
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-methoxyphenoxy)acetamide chemical structure, C20H21N3O4, CAS 33145-72-1
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-methoxyphenoxy)acetamide
CAS 33145-72-1C20H21N3O4
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(4-methylphenoxy)acetamide chemical structure, C20H21N3O3, CAS 65537-13-5
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(4-methylphenoxy)acetamide
CAS 65537-13-5C20H21N3O3
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(2-nitrophenoxy)acetamide chemical structure, C19H18N4O5, CAS 65537-08-8
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(2-nitrophenoxy)acetamide
CAS 65537-08-8C19H18N4O5
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(4-fluorophenoxy)acetamide chemical structure, C19H18FN3O3, CAS 380189-46-8
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(4-fluorophenoxy)acetamide
CAS 380189-46-8C19H18FN3O3
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-formyl-2-methoxyphenoxy)acetamide chemical structure, C21H21N3O5, CAS 838379-75-2
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-formyl-2-methoxyphenoxy)acetamide
CAS 838379-75-2C21H21N3O5
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-nitrophenoxy)acetamide chemical structure, C19H18N4O5, CAS 65537-06-6
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-nitrophenoxy)acetamide
CAS 65537-06-6C19H18N4O5
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(2-methylphenoxy)acetamide chemical structure, C20H21N3O3, CAS 65537-15-7
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(2-methylphenoxy)acetamide
CAS 65537-15-7C20H21N3O3
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-phenoxybutanamide chemical structure, C21H23N3O3, CAS 329220-72-6
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-phenoxybutanamide
CAS 329220-72-6C21H23N3O3
2-(2,4-Dichlorophenoxy)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)propanamide chemical structure, C20H19Cl2N3O3, CAS 353473-06-0
2-(2,4-Dichlorophenoxy)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)propanamide
CAS 353473-06-0C20H19Cl2N3O3
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(2,3,5,6-tetrafluorophenoxy)propanamide chemical structure, C20H17F4N3O3, CAS 361367-74-0
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(2,3,5,6-tetrafluorophenoxy)propanamide
CAS 361367-74-0C20H17F4N3O3
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(2-methoxyphenoxy)propanamide chemical structure, C21H23N3O4, CAS 381168-52-1
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(2-methoxyphenoxy)propanamide
CAS 381168-52-1C21H23N3O4
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-fluorophenoxy)propanamide chemical structure, C20H20FN3O3, CAS 439136-93-3
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-fluorophenoxy)propanamide
CAS 439136-93-3C20H20FN3O3
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(3,4-dimethylphenoxy)propanamide chemical structure, C22H25N3O3, CAS 692267-00-8
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(3,4-dimethylphenoxy)propanamide
CAS 692267-00-8C22H25N3O3
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-phenoxypropanamide chemical structure, C20H21N3O3, CAS 713490-41-6
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-phenoxypropanamide
CAS 713490-41-6C20H21N3O3
2-(3-Bromophenoxy)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide chemical structure, C19H18BrN3O3, CAS 342780-93-2
2-(3-Bromophenoxy)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide
CAS 342780-93-2C19H18BrN3O3
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-[3-(3-methylbutoxy)phenoxy]acetamide chemical structure, C24H29N3O4, CAS 392237-80-8
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-[3-(3-methylbutoxy)phenoxy]acetamide
CAS 392237-80-8C24H29N3O4
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-[3-(2-methylpropoxy)phenoxy]acetamide chemical structure, C23H27N3O4, CAS 392237-77-3
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-[3-(2-methylpropoxy)phenoxy]acetamide
CAS 392237-77-3C23H27N3O4
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(2-fluorophenoxy)propanamide chemical structure, C20H20FN3O3, CAS 617679-17-1
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(2-fluorophenoxy)propanamide
CAS 617679-17-1C20H20FN3O3
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(4-methylphenoxy)propanamide chemical structure, C21H23N3O3, CAS 723258-23-9
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(4-methylphenoxy)propanamide
CAS 723258-23-9C21H23N3O3
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(2-ethoxy-4-formylphenoxy)acetamide chemical structure, C22H23N3O5, CAS 881580-08-1
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(2-ethoxy-4-formylphenoxy)acetamide
CAS 881580-08-1C22H23N3O5