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Murcko scaffold

Ring system with 3 rings and 23 atoms

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
12
With full pages
6
Scaffold SMILES

O=S(=O)(C=Cc1ccccc1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=S(=O)(C=Cc1ccccc1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

1-Phenyl-4-[(E)-2-phenylethenyl]sulfonylpiperazine chemical structure, C18H20N2O2S, CAS 260441-26-7
1-Phenyl-4-[(E)-2-phenylethenyl]sulfonylpiperazine
CAS 260441-26-7C18H20N2O2S
Styryl[4-(4-fluorophenyl)piperazino] sulfone chemical structure, C18H19FN2O2S, CAS 260441-13-2
Styryl[4-(4-fluorophenyl)piperazino] sulfone
CAS 260441-13-2C18H19FN2O2S
1-(2-Phenylethenesulfonyl)-4-[3-(trifluoromethyl)phenyl]piperazine chemical structure, C19H19F3N2O2S, CAS 379699-03-3
1-(2-Phenylethenesulfonyl)-4-[3-(trifluoromethyl)phenyl]piperazine
CAS 379699-03-3C19H19F3N2O2S
1-(4-Methoxyphenyl)-4-[(2-phenylvinyl)sulfonyl]piperazine chemical structure, C19H22N2O3S, CAS 1164496-75-6
1-(4-Methoxyphenyl)-4-[(2-phenylvinyl)sulfonyl]piperazine
CAS 1164496-75-6C19H22N2O3S
(E)-1-(2-Methoxyphenyl)-4-(styrylsulfonyl)piperazine chemical structure, C19H22N2O3S, CAS 1164549-11-4
(E)-1-(2-Methoxyphenyl)-4-(styrylsulfonyl)piperazine
CAS 1164549-11-4C19H22N2O3S
1-(3-Chlorophenyl)-4-[(2-phenylvinyl)sulfonyl]piperazine chemical structure, C18H19ClN2O2S, CAS 1164468-23-8
1-(3-Chlorophenyl)-4-[(2-phenylvinyl)sulfonyl]piperazine
CAS 1164468-23-8C18H19ClN2O2S
3-Nitro-4-[4-(2-phenylethenesulfonyl)piperazin-1-yl]benzamide chemical structure, C19H20N4O5S
3-Nitro-4-[4-(2-phenylethenesulfonyl)piperazin-1-yl]benzamide
C19H20N4O5S
(E)-1-(4-Nitrophenyl)-4-(styrylsulfonyl)piperazine chemical structure, C18H19N3O4S, CAS 494825-76-2
(E)-1-(4-Nitrophenyl)-4-(styrylsulfonyl)piperazine
CAS 494825-76-2C18H19N3O4S
3-Nitro-4-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]benzamide chemical structure, C19H20N4O5S, CAS 741732-65-0
3-Nitro-4-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]benzamide
CAS 741732-65-0C19H20N4O5S
1-{4-[4-(2-Phenylethenesulfonyl)piperazin-1-yl]phenyl}ethan-1-one chemical structure, C20H22N2O3S, CAS 1198070-19-7
1-{4-[4-(2-Phenylethenesulfonyl)piperazin-1-yl]phenyl}ethan-1-one
CAS 1198070-19-7C20H22N2O3S
1-(2-Methylphenyl)-4-(2-phenylethenesulfonyl)piperazine chemical structure, C19H22N2O2S, CAS 930655-03-1
1-(2-Methylphenyl)-4-(2-phenylethenesulfonyl)piperazine
CAS 930655-03-1C19H22N2O2S
1-(2-Fluorophenyl)-4-(2-phenylethenesulfonyl)piperazine chemical structure, C18H19FN2O2S, CAS 925406-22-0
1-(2-Fluorophenyl)-4-(2-phenylethenesulfonyl)piperazine
CAS 925406-22-0C18H19FN2O2S