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Murcko scaffold

Ring system with 3 rings and 22 atoms

35 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
35
With full pages
3
Scaffold SMILES

C(=Cc1ccccc1)CN1CCN(Cc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C(=Cc1ccccc1)CN1CCN(Cc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 35 of 35 chemicals

1-[(3-Fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine chemical structure, C20H23FN2, CAS 1415587-74-4
1-[(3-Fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
CAS 1415587-74-4C20H23FN2
N,N-Dimethyl-4-[[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]methyl]aniline chemical structure, C22H29N3, CAS 414893-48-4
N,N-Dimethyl-4-[[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]methyl]aniline
CAS 414893-48-4C22H29N3
1-(4-Fluorobenzyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine chemical structure, C20H23FN2, CAS 414875-30-2
1-(4-Fluorobenzyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
CAS 414875-30-2C20H23FN2
1-[(4-Chlorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine chemical structure, C20H23ClN2, CAS 414882-09-0
1-[(4-Chlorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
CAS 414882-09-0C20H23ClN2
3-[[4-[(E)-3-Phenylprop-2-enyl]piperazin-1-yl]methyl]phenol chemical structure, C20H24N2O, CAS 1316696-27-1
3-[[4-[(E)-3-Phenylprop-2-enyl]piperazin-1-yl]methyl]phenol
CAS 1316696-27-1C20H24N2O
1-[(3-Methoxyphenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine chemical structure, C21H26N2O, CAS 331855-04-0
1-[(3-Methoxyphenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
CAS 331855-04-0C21H26N2O
2-Methoxy-4-[[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]methyl]phenol chemical structure, C21H26N2O2, CAS 414883-46-8
2-Methoxy-4-[[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]methyl]phenol
CAS 414883-46-8C21H26N2O2
1-[(2,4-Dichlorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine chemical structure, C20H22Cl2N2, CAS 414880-37-8
1-[(2,4-Dichlorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
CAS 414880-37-8C20H22Cl2N2
1-[(2E)-3-Phenylprop-2-en-1-yl]-4-[4-(trifluoromethyl)benzyl]piperazine chemical structure, C21H23F3N2, CAS 414893-70-2
1-[(2E)-3-Phenylprop-2-en-1-yl]-4-[4-(trifluoromethyl)benzyl]piperazine
CAS 414893-70-2C21H23F3N2
1-(4-Bromobenzyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine chemical structure, C20H23BrN2, CAS 414893-39-3
1-(4-Bromobenzyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
CAS 414893-39-3C20H23BrN2
1-[(3,4-Dichlorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine chemical structure, C20H22Cl2N2, CAS 414891-02-4
1-[(3,4-Dichlorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
CAS 414891-02-4C20H22Cl2N2
1-[(3-Bromophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine chemical structure, C20H23BrN2, CAS 414882-57-8
1-[(3-Bromophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
CAS 414882-57-8C20H23BrN2
1-[(2,3-Dichlorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine chemical structure, C20H22Cl2N2, CAS 331855-58-4
1-[(2,3-Dichlorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
CAS 331855-58-4C20H22Cl2N2
1-(2,4-Dimethoxybenzyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine chemical structure, C22H28N2O2, CAS 331855-80-2
1-(2,4-Dimethoxybenzyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
CAS 331855-80-2C22H28N2O2
1-[(4-Methylphenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine chemical structure, C21H26N2, CAS 331853-50-0
1-[(4-Methylphenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
CAS 331853-50-0C21H26N2
2,6-Dimethoxy-4-[[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]methyl]phenol chemical structure, C22H28N2O3, CAS 414875-45-9
2,6-Dimethoxy-4-[[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]methyl]phenol
CAS 414875-45-9C22H28N2O3
1-[(3-Methylphenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine chemical structure, C21H26N2, CAS 414876-61-2
1-[(3-Methylphenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
CAS 414876-61-2C21H26N2
1-(4-Isopropylbenzyl)-4-(3-phenylallyl)piperazine chemical structure, C23H30N2, CAS 331854-56-9
1-(4-Isopropylbenzyl)-4-(3-phenylallyl)piperazine
CAS 331854-56-9C23H30N2
1-[(3-Nitrophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine chemical structure, C20H23N3O2, CAS 1316890-71-7
1-[(3-Nitrophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
CAS 1316890-71-7C20H23N3O2
1-[(3,4-Dimethoxyphenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine chemical structure, C22H28N2O2, CAS 378203-37-3
1-[(3,4-Dimethoxyphenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
CAS 378203-37-3C22H28N2O2
1-[(2,5-Dimethoxyphenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine chemical structure, C22H28N2O2, CAS 414886-42-3
1-[(2,5-Dimethoxyphenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
CAS 414886-42-3C22H28N2O2
1-[(E)-3-Phenylprop-2-enyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine chemical structure, C23H30N2O3, CAS 113696-56-3
1-[(E)-3-Phenylprop-2-enyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine
CAS 113696-56-3C23H30N2O3
1-[(E)-3-Phenylprop-2-enyl]-4-[(3,4,5-trimethoxyphenyl)methyl]piperazine chemical structure, C23H30N2O3, CAS 374921-87-6
1-[(E)-3-Phenylprop-2-enyl]-4-[(3,4,5-trimethoxyphenyl)methyl]piperazine
CAS 374921-87-6C23H30N2O3
1-[(4-Ethoxyphenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine chemical structure, C22H28N2O, CAS 414889-09-1
1-[(4-Ethoxyphenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
CAS 414889-09-1C22H28N2O