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Murcko scaffold

1-Phenylpiperazine scaffold

6,403 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
6,403
With full pages
595
Scaffold SMILES

c1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperazine page
Murcko scaffold c1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 865 to 912 of 6,403 chemicals

Piperazine, 1-(4-methylphenyl)-4-(2-((trimethylsilyl)oxy)ethyl)- chemical structure, C16H28N2OSi, CAS 118161-82-3
Piperazine, 1-(4-methylphenyl)-4-(2-((trimethylsilyl)oxy)ethyl)-
CAS 118161-82-3C16H28N2OSi
Piperazine, 1-(3-methylphenyl)-4-(2-((trimethylsilyl)oxy)ethyl)- chemical structure, C16H28N2OSi, CAS 118161-83-4
Piperazine, 1-(3-methylphenyl)-4-(2-((trimethylsilyl)oxy)ethyl)-
CAS 118161-83-4C16H28N2OSi
1-Piperazineacetamide, 4-(2-hydroxyethyl)-N-phenyl-, dihydrochloride chemical structure, C14H23Cl2N3O2, CAS 118989-77-8
1-Piperazineacetamide, 4-(2-hydroxyethyl)-N-phenyl-, dihydrochloride
CAS 118989-77-8C14H23Cl2N3O2
1-Piperazineacetamide, 4-(3-hydroxypropyl)-N-phenyl-, dihydrochloride chemical structure, C15H25Cl2N3O2, CAS 118989-78-9
1-Piperazineacetamide, 4-(3-hydroxypropyl)-N-phenyl-, dihydrochloride
CAS 118989-78-9C15H25Cl2N3O2
1-(5-Chloro-2-nitrophenyl)-3,5-dimethylpiperazine chemical structure, C12H16ClN3O2, CAS 331652-59-6
1-(5-Chloro-2-nitrophenyl)-3,5-dimethylpiperazine
CAS 331652-59-6C12H16ClN3O2
2-[4-(2,4-Dinitrophenyl)piperazin-1-yl]ethanol chemical structure, C12H16N4O5, CAS 331652-62-1
2-[4-(2,4-Dinitrophenyl)piperazin-1-yl]ethanol
CAS 331652-62-1C12H16N4O5
Bis(2,2,2-trifluoroethyl) 4-{4-nitrophenyl}-1-piperazinylphosphonate chemical structure, C14H16F6N3O5P, CAS 331430-71-8
Bis(2,2,2-trifluoroethyl) 4-{4-nitrophenyl}-1-piperazinylphosphonate
CAS 331430-71-8C14H16F6N3O5P
1-(2,4-Dinitrophenyl)-4-methylpiperazine chemical structure, C11H14N4O4, CAS 58910-37-5
1-(2,4-Dinitrophenyl)-4-methylpiperazine
CAS 58910-37-5C11H14N4O4
1-Acetyl-4-(3-amino-4-nitrophenyl)piperazine chemical structure, C12H16N4O3, CAS 111861-03-1
1-Acetyl-4-(3-amino-4-nitrophenyl)piperazine
CAS 111861-03-1C12H16N4O3
2-Methyl-1-(methylsulfonyl)-4-(4-nitrophenyl)piperazine chemical structure, C12H17N3O4S, CAS 5669-65-8
2-Methyl-1-(methylsulfonyl)-4-(4-nitrophenyl)piperazine
CAS 5669-65-8C12H17N3O4S
3,5-Dimethyl-1-[2-nitro-4-(trifluoromethyl)phenyl]piperazine chemical structure, C13H16F3N3O2, CAS 327050-81-7
3,5-Dimethyl-1-[2-nitro-4-(trifluoromethyl)phenyl]piperazine
CAS 327050-81-7C13H16F3N3O2
1-Methyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine chemical structure, C12H14F3N3O2, CAS 309734-66-5
1-Methyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine
CAS 309734-66-5C12H14F3N3O2
2-Chloro-1-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethanone chemical structure, C13H17ClN2O2, CAS 21057-39-6
2-Chloro-1-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethanone
CAS 21057-39-6C13H17ClN2O2
1-(Chloroacetyl)-4-(2-fluorophenyl)piperazine chemical structure, C12H14ClFN2O, CAS 546116-24-9
1-(Chloroacetyl)-4-(2-fluorophenyl)piperazine
CAS 546116-24-9C12H14ClFN2O
5-Amino-2-(4-methylpiperazin-1-yl)benzamide chemical structure, C12H18N4O, CAS 60587-53-3
5-Amino-2-(4-methylpiperazin-1-yl)benzamide
CAS 60587-53-3C12H18N4O
3-Chloro-2-(4-methylpiperazin-1-yl)aniline chemical structure, C11H16ClN3, CAS 189761-97-5
3-Chloro-2-(4-methylpiperazin-1-yl)aniline
CAS 189761-97-5C11H16ClN3
N-[5-Chloro-2-(4-propanoylpiperazin-1-yl)phenyl]-2,2-dimethylpropanamide chemical structure, C18H26ClN3O2, CAS 876719-32-3
N-[5-Chloro-2-(4-propanoylpiperazin-1-yl)phenyl]-2,2-dimethylpropanamide
CAS 876719-32-3C18H26ClN3O2
[4-(4-Methoxyphenyl)piperazin-1-yl]acetic acid chemical structure, C13H18N2O3, CAS 169155-70-8
[4-(4-Methoxyphenyl)piperazin-1-yl]acetic acid
CAS 169155-70-8C13H18N2O3
(3-Chloro-4-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]phenyl)amine chemical structure, C15H22ClN3O, CAS 878441-21-5
(3-Chloro-4-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]phenyl)amine
CAS 878441-21-5C15H22ClN3O
N-Butan-2-yl-4-phenylpiperazine-1-carbothioamide chemical structure, C15H23N3S, CAS 461459-82-5
N-Butan-2-yl-4-phenylpiperazine-1-carbothioamide
CAS 461459-82-5C15H23N3S
2-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]ethanamine chemical structure, C13H20ClN3, CAS 321602-25-9
2-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]ethanamine
CAS 321602-25-9C13H20ClN3
2-[4-(2-Fluorophenyl)piperazin-1-yl]acetamide chemical structure, C12H16FN3O, CAS 697283-09-3
2-[4-(2-Fluorophenyl)piperazin-1-yl]acetamide
CAS 697283-09-3C12H16FN3O
1-(4-Bromo-2-fluorophenyl)piperazine chemical structure, C10H12BrFN2, CAS 501903-57-7
1-(4-Bromo-2-fluorophenyl)piperazine
CAS 501903-57-7C10H12BrFN2
Ethyl 3-{[4-(2-fluorophenyl)piperazine-1-carbothioyl]amino}propanoate chemical structure, C16H22FN3O2S, CAS 1022235-03-5
Ethyl 3-{[4-(2-fluorophenyl)piperazine-1-carbothioyl]amino}propanoate
CAS 1022235-03-5C16H22FN3O2S