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Murcko scaffold

1-Phenylpiperazine scaffold

6,403 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
6,403
With full pages
595
Scaffold SMILES

c1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperazine page
Murcko scaffold c1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 913 to 960 of 6,403 chemicals

1-Chloro-3-[4-(2-fluorophenyl)piperazin-1-yl]propan-2-ol chemical structure, C13H18ClFN2O, CAS 865660-68-0
1-Chloro-3-[4-(2-fluorophenyl)piperazin-1-yl]propan-2-ol
CAS 865660-68-0C13H18ClFN2O
5-[4-(2-Fluorophenyl)piperazin-1-yl]-5-oxopentanoic acid chemical structure, C15H19FN2O3, CAS 757200-80-9
5-[4-(2-Fluorophenyl)piperazin-1-yl]-5-oxopentanoic acid
CAS 757200-80-9C15H19FN2O3
2-(4-Ethylpiperazin-1-yl)-5-(trifluoromethyl)aniline chemical structure, C13H18F3N3, CAS 937596-13-9
2-(4-Ethylpiperazin-1-yl)-5-(trifluoromethyl)aniline
CAS 937596-13-9C13H18F3N3
1-(2-Chlorophenyl)-4-hexylpiperazine chemical structure, C16H25ClN2, CAS 866151-38-4
1-(2-Chlorophenyl)-4-hexylpiperazine
CAS 866151-38-4C16H25ClN2
4-(2-Chloro-6-nitrophenyl)-2-methyl-1-methylsulfonylpiperazine chemical structure, C12H16ClN3O4S, CAS 330177-58-7
4-(2-Chloro-6-nitrophenyl)-2-methyl-1-methylsulfonylpiperazine
CAS 330177-58-7C12H16ClN3O4S
1,1,1-Trifluoro-3-[4-(4-methoxyphenyl)piperazin-1-yl]propan-2-ol chemical structure, C14H19F3N2O2, CAS 866135-78-6
1,1,1-Trifluoro-3-[4-(4-methoxyphenyl)piperazin-1-yl]propan-2-ol
CAS 866135-78-6C14H19F3N2O2
N,N-Diethyl-3-nitro-4-piperazin-1-ylbenzenesulfonamide chemical structure, C14H22N4O4S, CAS 743440-22-4
N,N-Diethyl-3-nitro-4-piperazin-1-ylbenzenesulfonamide
CAS 743440-22-4C14H22N4O4S
[2-Oxo-2-(4-phenylpiperazin-1-yl)ethoxy]acetic acid chemical structure, C14H18N2O4, CAS 737774-20-8
[2-Oxo-2-(4-phenylpiperazin-1-yl)ethoxy]acetic acid
CAS 737774-20-8C14H18N2O4
1-(4-Fluorophenyl)-4-hexylpiperazine chemical structure, C16H25FN2, CAS 866151-35-1
1-(4-Fluorophenyl)-4-hexylpiperazine
CAS 866151-35-1C16H25FN2
3-Methyl-N-{[4-(4-propanoylpiperazin-1-yl)phenyl]carbamothioyl}butanamide chemical structure, C19H28N4O2S, CAS 678156-68-8
3-Methyl-N-{[4-(4-propanoylpiperazin-1-yl)phenyl]carbamothioyl}butanamide
CAS 678156-68-8C19H28N4O2S
N,N-Dimethyl-4-(4-nitrophenyl)piperazine-1-sulfonamide chemical structure, C12H18N4O4S, CAS 349573-54-2
N,N-Dimethyl-4-(4-nitrophenyl)piperazine-1-sulfonamide
CAS 349573-54-2C12H18N4O4S
1-(3,4-Dichlorophenyl)-4-octylpiperazine chemical structure, C18H28Cl2N2, CAS 866151-52-2
1-(3,4-Dichlorophenyl)-4-octylpiperazine
CAS 866151-52-2C18H28Cl2N2
1-(4-Chlorophenyl)-4-hexylpiperazine chemical structure, C16H25ClN2, CAS 866151-37-3
1-(4-Chlorophenyl)-4-hexylpiperazine
CAS 866151-37-3C16H25ClN2
1-Hexyl-4-(2-methylphenyl)piperazine chemical structure, C17H28N2, CAS 866151-47-5
1-Hexyl-4-(2-methylphenyl)piperazine
CAS 866151-47-5C17H28N2
1-(2-Bromo-4-fluorophenyl)piperazine chemical structure, C10H12BrFN2, CAS 186387-02-0
1-(2-Bromo-4-fluorophenyl)piperazine
CAS 186387-02-0C10H12BrFN2
3-Imino-3-[4-(4-methoxyphenyl)piperazin-1-yl]propanenitrile chemical structure, C14H18N4O, CAS 338396-63-7
3-Imino-3-[4-(4-methoxyphenyl)piperazin-1-yl]propanenitrile
CAS 338396-63-7C14H18N4O
1-Hexyl-4-(4-methoxyphenyl)piperazine chemical structure, C17H28N2O, CAS 79072-38-1
1-Hexyl-4-(4-methoxyphenyl)piperazine
CAS 79072-38-1C17H28N2O
1-(4-Bromo-2-methylphenyl)piperazine chemical structure, C11H15BrN2, CAS 501903-60-2
1-(4-Bromo-2-methylphenyl)piperazine
CAS 501903-60-2C11H15BrN2
Ethyl 5-amino-2,4-dicyano-5-[4-(4-methoxyphenyl)piperazino]-2,4-pentadienoate chemical structure, C20H23N5O3
Ethyl 5-amino-2,4-dicyano-5-[4-(4-methoxyphenyl)piperazino]-2,4-pentadienoate
C20H23N5O3
2-Chloro-1-[4-(2-methoxyphenyl)piperazino]propan-1-one chemical structure, C14H19ClN2O2, CAS 95395-48-5
2-Chloro-1-[4-(2-methoxyphenyl)piperazino]propan-1-one
CAS 95395-48-5C14H19ClN2O2
1-(2-Methoxy-5-nitrophenyl)piperazine chemical structure, C11H15N3O3, CAS 58315-37-0
1-(2-Methoxy-5-nitrophenyl)piperazine
CAS 58315-37-0C11H15N3O3
1,1,1-Trifluoro-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-2-ol chemical structure, C13H16F3N3O3, CAS 478258-73-0
1,1,1-Trifluoro-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-2-ol
CAS 478258-73-0C13H16F3N3O3
1-(3-Chloro-2-methylphenyl)piperazine chemical structure, C11H15ClN2, CAS 54711-70-5
1-(3-Chloro-2-methylphenyl)piperazine
CAS 54711-70-5C11H15ClN2
1-Chloro-3-{4-[3-(trifluoromethyl)phenyl]piperazino}-2-propanol chemical structure, C14H18ClF3N2O, CAS 578742-26-4
1-Chloro-3-{4-[3-(trifluoromethyl)phenyl]piperazino}-2-propanol
CAS 578742-26-4C14H18ClF3N2O