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Murcko scaffold

1-Phenylpiperazine scaffold

6,403 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
6,403
With full pages
595
Scaffold SMILES

c1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperazine page
Murcko scaffold c1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1,057 to 1,104 of 6,403 chemicals

3-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-propionic acid chemical structure, C14H20N2O3, CAS 883546-69-8
3-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-propionic acid
CAS 883546-69-8C14H20N2O3
1-(2-Chloroethyl)-4-(4-methoxyphenyl)piperazine chemical structure, C13H19ClN2O, CAS 70957-94-7
1-(2-Chloroethyl)-4-(4-methoxyphenyl)piperazine
CAS 70957-94-7C13H19ClN2O
2-[4-(3-Methylphenyl)piperazin-1-yl]acetic acid chemical structure, C13H18N2O2, CAS 896523-47-0
2-[4-(3-Methylphenyl)piperazin-1-yl]acetic acid
CAS 896523-47-0C13H18N2O2
1-(2-Chloroethyl)-4-phenylpiperazine chemical structure, C12H17ClN2, CAS 43219-09-6
1-(2-Chloroethyl)-4-phenylpiperazine
CAS 43219-09-6C12H17ClN2
2-(4-o-Tolyl-piperazin-1-yl)-ethylamine chemical structure, C13H21N3, CAS 58334-09-1
2-(4-o-Tolyl-piperazin-1-yl)-ethylamine
CAS 58334-09-1C13H21N3
2-[4-(3-Methylphenyl)piperazin-1-yl]ethanamine chemical structure, C13H21N3, CAS 21103-27-5
2-[4-(3-Methylphenyl)piperazin-1-yl]ethanamine
CAS 21103-27-5C13H21N3
2-(4-Phenylpiperazin-1-yl)ethan-1-amine chemical structure, C12H19N3, CAS 21091-61-2
2-(4-Phenylpiperazin-1-yl)ethan-1-amine
CAS 21091-61-2C12H19N3
2-(4-(3-Nitrophenyl)piperazin-1-yl)ethanol chemical structure, C12H17N3O3, CAS 944663-75-6
2-(4-(3-Nitrophenyl)piperazin-1-yl)ethanol
CAS 944663-75-6C12H17N3O3
2-[4-(2,4-Dimethylphenyl)piperazin-1-yl]ethanol chemical structure, C14H22N2O, CAS 944678-51-7
2-[4-(2,4-Dimethylphenyl)piperazin-1-yl]ethanol
CAS 944678-51-7C14H22N2O
2-[4-(2,5-Dimethylphenyl)piperazin-1-yl]ethanol chemical structure, C14H22N2O, CAS 944509-68-6
2-[4-(2,5-Dimethylphenyl)piperazin-1-yl]ethanol
CAS 944509-68-6C14H22N2O
4-(4-Methoxyphenyl)-1-piperazineethanol chemical structure, C13H20N2O2, CAS 40004-67-9
4-(4-Methoxyphenyl)-1-piperazineethanol
CAS 40004-67-9C13H20N2O2
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-2-chloroacetamide chemical structure, C14H18ClN3O2, CAS 887709-89-9
N-[4-(4-Acetylpiperazin-1-yl)phenyl]-2-chloroacetamide
CAS 887709-89-9C14H18ClN3O2
3-Chloro-4-(4-propylpiperazin-1-yl)aniline chemical structure, C13H20ClN3, CAS 944532-71-2
3-Chloro-4-(4-propylpiperazin-1-yl)aniline
CAS 944532-71-2C13H20ClN3
Ethyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate chemical structure, C14H16N4O4, CAS 849484-94-2
Ethyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate
CAS 849484-94-2C14H16N4O4
3-Nitro-4-(4-propylpiperazin-1-yl)benzenesulfonamide chemical structure, C13H20N4O4S, CAS 852225-81-1
3-Nitro-4-(4-propylpiperazin-1-yl)benzenesulfonamide
CAS 852225-81-1C13H20N4O4S
2-[4-(2-Formyl-4-nitrophenyl)piperazin-1-yl]-N-propan-2-ylacetamide chemical structure, C16H22N4O4, CAS 848299-06-9
2-[4-(2-Formyl-4-nitrophenyl)piperazin-1-yl]-N-propan-2-ylacetamide
CAS 848299-06-9C16H22N4O4
1-[4-(4-Methylpiperazin-1-yl)phenyl]ethan-1-amine chemical structure, C13H21N3, CAS 869945-77-7
1-[4-(4-Methylpiperazin-1-yl)phenyl]ethan-1-amine
CAS 869945-77-7C13H21N3
3-(4-Methyl-1-piperazinyl)benzenemethanamine chemical structure, C12H19N3, CAS 672325-37-0
3-(4-Methyl-1-piperazinyl)benzenemethanamine
CAS 672325-37-0C12H19N3
tert-Butyl 4-[2-(aminomethyl)phenyl]piperazine-1-carboxylate chemical structure, C16H25N3O2, CAS 174855-53-9
tert-Butyl 4-[2-(aminomethyl)phenyl]piperazine-1-carboxylate
CAS 174855-53-9C16H25N3O2
3-Amino-N,N-diethyl-4-(4-ethylpiperazin-1-yl)benzene-1-sulfonamide chemical structure, C16H28N4O2S, CAS 794554-67-9
3-Amino-N,N-diethyl-4-(4-ethylpiperazin-1-yl)benzene-1-sulfonamide
CAS 794554-67-9C16H28N4O2S
5-Bromo-2-(4-methylpiperazin-1-yl)aniline chemical structure, C11H16BrN3, CAS 885461-06-3
5-Bromo-2-(4-methylpiperazin-1-yl)aniline
CAS 885461-06-3C11H16BrN3
4-(4-Acetylpiperazin-1-yl)-3-nitrobenzoic acid chemical structure, C13H15N3O5, CAS 309943-00-8
4-(4-Acetylpiperazin-1-yl)-3-nitrobenzoic acid
CAS 309943-00-8C13H15N3O5
4-(2-Chlorophenyl)-N-(1-methoxypropan-2-yl)piperazine-1-carbothioamide chemical structure, C15H22ClN3OS, CAS 851711-05-2
4-(2-Chlorophenyl)-N-(1-methoxypropan-2-yl)piperazine-1-carbothioamide
CAS 851711-05-2C15H22ClN3OS
N-Butyl-4-(2-fluorophenyl)piperazine-1-carboxamide chemical structure, C15H22FN3O, CAS 497060-81-8
N-Butyl-4-(2-fluorophenyl)piperazine-1-carboxamide
CAS 497060-81-8C15H22FN3O