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Murcko scaffold

1-Phenylpiperazine scaffold

6,403 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
6,403
With full pages
595
Scaffold SMILES

c1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperazine page
Murcko scaffold c1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1,105 to 1,152 of 6,403 chemicals

(2Z)-3-Amino-3-[4-(3,4-dichlorophenyl)piperazin-1-yl]prop-2-enenitrile chemical structure, C13H14Cl2N4, CAS 1164541-77-8
(2Z)-3-Amino-3-[4-(3,4-dichlorophenyl)piperazin-1-yl]prop-2-enenitrile
CAS 1164541-77-8C13H14Cl2N4
Ethyl (E)-2-cyano-3-[4-(4-fluorophenyl)piperazin-1-yl]prop-2-enoate chemical structure, C16H18FN3O2, CAS 1024795-93-4
Ethyl (E)-2-cyano-3-[4-(4-fluorophenyl)piperazin-1-yl]prop-2-enoate
CAS 1024795-93-4C16H18FN3O2
(E)-1,1,1-Trifluoro-4-(4-phenylpiperazin-1-yl)but-3-en-2-one chemical structure, C14H15F3N2O, CAS 478047-04-0
(E)-1,1,1-Trifluoro-4-(4-phenylpiperazin-1-yl)but-3-en-2-one
CAS 478047-04-0C14H15F3N2O
(2E)-3-(Dimethylamino)-1-[4-(4-methylpiperazin-1-yl)phenyl]prop-2-en-1-one chemical structure, C16H23N3O, CAS 338975-38-5
(2E)-3-(Dimethylamino)-1-[4-(4-methylpiperazin-1-yl)phenyl]prop-2-en-1-one
CAS 338975-38-5C16H23N3O
Ethyl 3-(4-(5-chloro-2-methylphenyl)piperazinyl)-2-cyanoprop-2-enoate chemical structure, C17H20ClN3O2, CAS 1025148-36-0
Ethyl 3-(4-(5-chloro-2-methylphenyl)piperazinyl)-2-cyanoprop-2-enoate
CAS 1025148-36-0C17H20ClN3O2
(E)-1,1,1-Trifluoro-4-{4-[3-(trifluoromethyl)phenyl]piperazino}-3-buten-2-one chemical structure, C15H14F6N2O, CAS 672949-81-4
(E)-1,1,1-Trifluoro-4-{4-[3-(trifluoromethyl)phenyl]piperazino}-3-buten-2-one
CAS 672949-81-4C15H14F6N2O
Ethyl 2-({3-amino-3-[4-(3-chlorophenyl)piperazino]-2-cyano-2-propenethioyl}amino)acetate chemical structure, C18H22ClN5O2S, CAS 338966-45-3
Ethyl 2-({3-amino-3-[4-(3-chlorophenyl)piperazino]-2-cyano-2-propenethioyl}amino)acetate
CAS 338966-45-3C18H22ClN5O2S
Diethyl (E,4E)-4-[amino-[4-(2,6-dimethylphenyl)piperazin-1-yl]methylidene]-2-cyanopent-2-enedioate chemical structure, C23H30N4O4, CAS 338406-32-9
Diethyl (E,4E)-4-[amino-[4-(2,6-dimethylphenyl)piperazin-1-yl]methylidene]-2-cyanopent-2-enedioate
CAS 338406-32-9C23H30N4O4
Ethyl (2E,4Z)-5-amino-2,4-dicyano-5-[4-(4-methoxyphenyl)piperazin-1-yl]penta-2,4-dienoate chemical structure, C20H23N5O3
Ethyl (2E,4Z)-5-amino-2,4-dicyano-5-[4-(4-methoxyphenyl)piperazin-1-yl]penta-2,4-dienoate
C20H23N5O3
(3E)-4-Amino-4-[4-(3-chlorophenyl)piperazin-1-yl]buta-1,3-diene-1,1,3-tricarbonitrile chemical structure, C17H15ClN6, CAS 338794-96-0
(3E)-4-Amino-4-[4-(3-chlorophenyl)piperazin-1-yl]buta-1,3-diene-1,1,3-tricarbonitrile
CAS 338794-96-0C17H15ClN6
1-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-4-[1-(methylsulfanyl)-2-nitrovinyl]piperazine chemical structure, C14H14F3N5O6S, CAS 343375-56-4
1-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-4-[1-(methylsulfanyl)-2-nitrovinyl]piperazine
CAS 343375-56-4C14H14F3N5O6S
Diethyl (E,4E)-4-[amino-[4-(4-chlorophenyl)piperazin-1-yl]methylidene]-2-cyanopent-2-enedioate chemical structure, C21H25ClN4O4, CAS 338406-34-1
Diethyl (E,4E)-4-[amino-[4-(4-chlorophenyl)piperazin-1-yl]methylidene]-2-cyanopent-2-enedioate
CAS 338406-34-1C21H25ClN4O4
(2E)-4,4-Dimethyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]methylidene]-3-oxopentanenitrile chemical structure, C19H25N3O, CAS 1025284-44-9
(2E)-4,4-Dimethyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]methylidene]-3-oxopentanenitrile
CAS 1025284-44-9C19H25N3O
Diethyl (E,4E)-4-[amino-[4-(4-methoxyphenyl)piperazin-1-yl]methylidene]-2-cyanopent-2-enedioate chemical structure, C22H28N4O5, CAS 338396-59-1
Diethyl (E,4E)-4-[amino-[4-(4-methoxyphenyl)piperazin-1-yl]methylidene]-2-cyanopent-2-enedioate
CAS 338396-59-1C22H28N4O5
Ethyl (2E)-3-amino-2-(cyanosulfanyl)-3-[4-(4-methoxyphenyl)piperazin-1-yl]prop-2-enoate chemical structure, C17H22N4O3S, CAS 338410-23-4
Ethyl (2E)-3-amino-2-(cyanosulfanyl)-3-[4-(4-methoxyphenyl)piperazin-1-yl]prop-2-enoate
CAS 338410-23-4C17H22N4O3S
Ethyl (2E)-2-cyano-3-(4-phenylpiperazin-1-yl)prop-2-enoate chemical structure, C16H19N3O2, CAS 946386-13-6
Ethyl (2E)-2-cyano-3-(4-phenylpiperazin-1-yl)prop-2-enoate
CAS 946386-13-6C16H19N3O2
Ethyl (2Z)-3-[4-(4-fluorophenyl)piperazin-1-yl]-2-methoxyiminopropanoate chemical structure, C16H22FN3O3, CAS 478077-51-9
Ethyl (2Z)-3-[4-(4-fluorophenyl)piperazin-1-yl]-2-methoxyiminopropanoate
CAS 478077-51-9C16H22FN3O3
3-Amino-3-[4-(3,4-dichlorophenyl)piperazino]acrylonitrile chemical structure, C13H14Cl2N4
3-Amino-3-[4-(3,4-dichlorophenyl)piperazino]acrylonitrile
C13H14Cl2N4
(2E)-4,4-Dimethyl-3-oxo-2-[(4-phenylpiperazin-1-yl)methylidene]pentanenitrile chemical structure, C18H23N3O
(2E)-4,4-Dimethyl-3-oxo-2-[(4-phenylpiperazin-1-yl)methylidene]pentanenitrile
C18H23N3O
Diethyl (E,4E)-4-[amino-(4-phenylpiperazin-1-yl)methylidene]-2-cyanopent-2-enedioate chemical structure, C21H26N4O4, CAS 338396-62-6
Diethyl (E,4E)-4-[amino-(4-phenylpiperazin-1-yl)methylidene]-2-cyanopent-2-enedioate
CAS 338396-62-6C21H26N4O4
4-Amino-4-[4-(4-chlorophenyl)piperazino]-1,3-butadiene-1,1,3-tricarbonitrile chemical structure, C17H15ClN6, CAS 1164531-01-4
4-Amino-4-[4-(4-chlorophenyl)piperazino]-1,3-butadiene-1,1,3-tricarbonitrile
CAS 1164531-01-4C17H15ClN6
Caldaret chemical structure, C11H16N2O3S, CAS 133804-44-1
Caldaret
CAS 133804-44-1C11H16N2O3S
DU 27725 chemical structure, C19H24F3N3O5, CAS 76716-82-0
DU 27725
CAS 76716-82-0C19H24F3N3O5
Piperazine, 1-phenyl-, maleate chemical structure, C14H18N2O4, CAS 23168-93-6
Piperazine, 1-phenyl-, maleate
CAS 23168-93-6C14H18N2O4