Murcko scaffold
1-Phenylpiperazine scaffold
6,403 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 12
- Chemicals
- 6,403
- With full pages
- 595
Scaffold SMILES
c1ccc(N2CCNCC2)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1,153 to 1,200 of 6,403 chemicals
1-(2-Chlorophenyl)-4-(methylsulfonyl)piperazine
CAS 150557-75-8C11H15ClN2O2S
![Ethyl 2-[4-(3,4-dichlorophenyl)piperazinyl]acetate chemical structure, C14H18Cl2N2O2, CAS 896236-51-4](/s/ABLDHSRUDYDZRF-UHFFFAOYSA-N.svg)
Ethyl 2-[4-(3,4-dichlorophenyl)piperazinyl]acetate
CAS 896236-51-4C14H18Cl2N2O2
N-Butyl-3-methyl-4-(4-methylphenyl)piperazine-1-carboxamide
CAS 894258-52-7C17H27N3O
1-Butylsulfonyl-4-(5-chloro-2-methylphenyl)piperazine
CAS 898063-11-1C15H23ClN2O2S
1-(Ethanesulfonyl)-4-(4-methoxyphenyl)piperazine
CAS 898060-48-5C13H20N2O3S
![2-[4-(3-Methoxyphenyl)piperazin-1-yl]acetamide chemical structure, C13H19N3O2, CAS 885445-31-8](/s/HHYFZMJTFSQKQS-UHFFFAOYSA-N.svg)
2-[4-(3-Methoxyphenyl)piperazin-1-yl]acetamide
CAS 885445-31-8C13H19N3O2
![Methyl 2-[4-(4-chlorophenyl)piperazin-1-yl]acetate chemical structure, C13H17ClN2O2, CAS 896263-55-1](/s/ZOSBGGRXUBFAPW-UHFFFAOYSA-N.svg)
Methyl 2-[4-(4-chlorophenyl)piperazin-1-yl]acetate
CAS 896263-55-1C13H17ClN2O2
![2-[4-(2-Ethoxyphenyl)piperazin-1-yl]acetamide chemical structure, C14H21N3O2, CAS 885435-02-9](/s/MMNQCQSGQHXQMO-UHFFFAOYSA-N.svg)
2-[4-(2-Ethoxyphenyl)piperazin-1-yl]acetamide
CAS 885435-02-9C14H21N3O2
1-Butylsulfonyl-4-(4-methoxyphenyl)piperazine
CAS 898060-64-5C15H24N2O3S
N-Butyl-4-(5-chloro-2-methylphenyl)piperazine-1-carboxamide
CAS 875464-20-3C16H24ClN3O
![Ethyl 2-[4-(3-methoxyphenyl)piperazinyl]acetate chemical structure, C15H22N2O3, CAS 853745-74-1](/s/NQGUFNFCFSOBOI-UHFFFAOYSA-N.svg)
Ethyl 2-[4-(3-methoxyphenyl)piperazinyl]acetate
CAS 853745-74-1C15H22N2O3
![Methyl 2-[4-(3-chlorophenyl)piperazinyl]acetate chemical structure, C13H17ClN2O2, CAS 896240-11-2](/s/FZMFOSSQYTXISR-UHFFFAOYSA-N.svg)
Methyl 2-[4-(3-chlorophenyl)piperazinyl]acetate
CAS 896240-11-2C13H17ClN2O2
![2-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]acetamide chemical structure, C13H18ClN3O, CAS 885429-36-7](/s/YGJITWAQNHWKEK-UHFFFAOYSA-N.svg)
2-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]acetamide
CAS 885429-36-7C13H18ClN3O
![Methyl 2-[4-(3-methoxyphenyl)piperazinyl]acetate chemical structure, C14H20N2O3, CAS 885445-44-3](/s/DCILPPQPAQEZKF-UHFFFAOYSA-N.svg)
Methyl 2-[4-(3-methoxyphenyl)piperazinyl]acetate
CAS 885445-44-3C14H20N2O3
![2-[4-[3-(Trifluoromethyl)phenyl]piperazin-1-yl]acetamide chemical structure, C13H16F3N3O, CAS 63556-35-4](/s/VRWKGUGTZPZDQZ-UHFFFAOYSA-N.svg)
2-[4-[3-(Trifluoromethyl)phenyl]piperazin-1-yl]acetamide
CAS 63556-35-4C13H16F3N3O
![2-[3-Methyl-4-(4-methylphenyl)piperazin-1-yl]acetamide chemical structure, C14H21N3O, CAS 885449-72-9](/s/YFVJNYYXHHWDHE-UHFFFAOYSA-N.svg)
2-[3-Methyl-4-(4-methylphenyl)piperazin-1-yl]acetamide
CAS 885449-72-9C14H21N3O
![5-[4-(3,4-Dichlorophenyl)piperazin-1-yl]-5-oxopentanoic acid chemical structure, C15H18Cl2N2O3, CAS 904795-08-0](/s/DRUJBHWVCRDJJX-UHFFFAOYSA-N.svg)
5-[4-(3,4-Dichlorophenyl)piperazin-1-yl]-5-oxopentanoic acid
CAS 904795-08-0C15H18Cl2N2O3
![Methyl 2-[4-(3,4-dichlorophenyl)piperazinyl]acetate chemical structure, C13H16Cl2N2O2, CAS 896236-59-2](/s/QTXVFZIODDSBHN-UHFFFAOYSA-N.svg)
Methyl 2-[4-(3,4-dichlorophenyl)piperazinyl]acetate
CAS 896236-59-2C13H16Cl2N2O2
N-Butyl-4-(2,3-dimethylphenyl)piperazine-1-carboxamide
CAS 894258-38-9C17H27N3O
4-(Ethylsulfonyl)-2-methyl-1-(4-methylphenyl)piperazine
CAS 898082-61-6C14H22N2O2S
![N-[3-Chloro-4-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]phenyl]acetamide chemical structure, C17H24ClN3O2, CAS 898114-80-2](/s/JMCOPNSFZRDRMS-UHFFFAOYSA-N.svg)
N-[3-Chloro-4-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]phenyl]acetamide
CAS 898114-80-2C17H24ClN3O2
![{3-Chloro-4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl}amine chemical structure, C15H22ClN3O, CAS 879020-32-3](/s/XFQSSIDQJNTSBH-UHFFFAOYSA-N.svg)
{3-Chloro-4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl}amine
CAS 879020-32-3C15H22ClN3O
![N-[3-Chloro-4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl]-2-methylpropanamide chemical structure, C19H28ClN3O2, CAS 898112-76-0](/s/GERKCCKBAKPCPY-UHFFFAOYSA-N.svg)
N-[3-Chloro-4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl]-2-methylpropanamide
CAS 898112-76-0C19H28ClN3O2
![2-Methyl-N-[4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl]propanamide chemical structure, C19H29N3O2, CAS 895082-69-6](/s/SKRUBGQBBBBRCM-UHFFFAOYSA-N.svg)
2-Methyl-N-[4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl]propanamide
CAS 895082-69-6C19H29N3O2
- 1 suppliers5-Fluoro-2-(4-methylpiperazin-1-yl)aniline869944-01-4C11H16FN3
- 2-[4-(2-Amino-phenyl)-piperazin-1-yl]-ethanol869946-18-9C12H19N3O
- 2-[4-(4-Amino-2-chloro-phenyl)-piperazin-1-yl]-ethanol878046-65-2C12H18ClN3O
- 4-(4-Acetyl-1-piperazinyl)-3-fluorobenzonitrile878620-27-0C13H14FN3O
- 2-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-N-(prop-2-en-1-yl)acetamide903275-00-3C16H22ClN3O
- 4-(3-Chloro-2-methylphenyl)-N,N-dimethylpiperazine-1-sulfonamide825607-66-7C13H20ClN3O2S
- 2 suppliers1-Boc-4-(2-formylphenyl)piperazine174855-57-3C16H22N2O3
- 3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propionic acid732298-45-2C14H20N2O3
- 4-(4-Methylpiperazin-1-yl)-3-(trifluoromethyl)aniline330796-48-0C12H16F3N3
- Ethyl (2E)-2-cyano-3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}prop-2-enoate1025533-14-5C17H18F3N3O2
- 4-Amino-4-[4-(3,4-dichlorophenyl)piperazino]-1,3-butadiene-1,1,3-tricarbonitrile338795-07-6C17H14Cl2N6
- 1-(2,6-Dimethoxyphenyl)piperazine148583-59-9C12H18N2O2
- cis-3,5-Dimethyl-1-(4-nitrophenyl)piperazine153747-81-0C12H17N3O2
- 2-Chloro-1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone75049-21-7C12H15ClN2O2
- 1 supplierstert-Butyl 4-[2-(hydroxymethyl)phenyl]piperazine-1-carboxylate179250-28-3C16H24N2O3
- N,N-Diethyl-4-piperazin-1-yl-benzenesulfonamide886504-23-0C14H23N3O2S
- 3-[4-(4-Fluorophenyl)piperazin-1-yl]propan-1-amine40255-43-4C13H20FN3
- 1-[4-(Propylsulfonyl)phenyl]piperazine886506-18-9C13H20N2O2S
- 1 supplierstert-Butyl 4-{4-[(methylamino)methyl]phenyl}piperazine-1-carboxylate681508-91-8C17H27N3O2
- 1 suppliers3-(4-Methylpiperazin-1-yl)benzonitrile204078-35-3C12H15N3
- N-(2-((4-(2-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)isobutyramide897613-32-0C16H24FN3O3S
- N-(2-((4-(2-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)pivalamide897613-34-2C17H26FN3O3S
- N-(2-((4-Phenylpiperazin-1-yl)sulfonyl)ethyl)propionamide897611-54-0C15H23N3O3S
- N-(2-((4-(2-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)methanesulfonamide897622-09-2C13H20FN3O4S2
Related scaffolds
Same ring framework with different atoms or bond orders
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c1ccc(N2CCOCC2)cc1202 chemicals
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c1ccc(-c2ncccn2)cc1107 chemicals
c1ccc(-c2ccncn2)cc1106 chemicals