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Murcko scaffold

1-Phenylpiperazine scaffold

6,403 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
6,403
With full pages
595
Scaffold SMILES

c1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperazine page
Murcko scaffold c1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1,249 to 1,296 of 6,403 chemicals

4-(3-Hydroxyphenyl)-1,1-dimethylpiperazinium chemical structure, C12H19N2O+, CAS 777049-59-9
4-(3-Hydroxyphenyl)-1,1-dimethylpiperazinium
CAS 777049-59-9C12H19N2O+
4-Methoxy-3-(4-methyl-1-piperazinyl)benzoic acid chemical structure, C13H18N2O3, CAS 847871-76-5
4-Methoxy-3-(4-methyl-1-piperazinyl)benzoic acid
CAS 847871-76-5C13H18N2O3
1-(2-Chloroethyl)-4-(3-chlorophenyl)piperazine chemical structure, C12H16Cl2N2, CAS 63377-88-8
1-(2-Chloroethyl)-4-(3-chlorophenyl)piperazine
CAS 63377-88-8C12H16Cl2N2
4-Methoxy-3-(4-methyl-piperazin-1-yl)-benzoic acid methyl ester chemical structure, C14H20N2O3, CAS 148672-70-2
4-Methoxy-3-(4-methyl-piperazin-1-yl)-benzoic acid methyl ester
CAS 148672-70-2C14H20N2O3
2-Chloro-1-[4-(2-nitrophenyl)piperazin-1-yl]ethan-1-one chemical structure, C12H14ClN3O3, CAS 1000930-18-6
2-Chloro-1-[4-(2-nitrophenyl)piperazin-1-yl]ethan-1-one
CAS 1000930-18-6C12H14ClN3O3
Piperazine, 1-(2-chloroethyl)-4-(2-chlorophenyl)- chemical structure, C12H16Cl2N2, CAS 63377-89-9
Piperazine, 1-(2-chloroethyl)-4-(2-chlorophenyl)-
CAS 63377-89-9C12H16Cl2N2
Piperazine, 1-heptyl-4-phenyl- chemical structure, C17H28N2, CAS 112898-90-5
Piperazine, 1-heptyl-4-phenyl-
CAS 112898-90-5C17H28N2
(2R)-N-[2-Chloro-4-ethylsulfonyl-3-(4-methylpiperazin-1-yl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide chemical structure, C17H23ClF3N3O4S, CAS 500577-21-9
(2R)-N-[2-Chloro-4-ethylsulfonyl-3-(4-methylpiperazin-1-yl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide
CAS 500577-21-9C17H23ClF3N3O4S
(2S)-3-(1-Oxido-4-phenylpiperazin-1-ium-1-yl)propane-1,2-diol chemical structure, C13H20N2O3, CAS 152237-40-6
(2S)-3-(1-Oxido-4-phenylpiperazin-1-ium-1-yl)propane-1,2-diol
CAS 152237-40-6C13H20N2O3
1-Hexyl-4-phenylpiperazine chemical structure, C16H26N2, CAS 104393-81-9
1-Hexyl-4-phenylpiperazine
CAS 104393-81-9C16H26N2
4-Methoxy-3-(4-methylpiperazin-1-yl)aniline chemical structure, C12H19N3O, CAS 148546-78-5
4-Methoxy-3-(4-methylpiperazin-1-yl)aniline
CAS 148546-78-5C12H19N3O
1-Butyl-4-(2-methoxy-phenyl)-piperazine chemical structure, C15H24N2O, CAS 93151-61-2
1-Butyl-4-(2-methoxy-phenyl)-piperazine
CAS 93151-61-2C15H24N2O
3-(4-Acetyl-piperazin-1-yl)-4-chloroaniline chemical structure, C12H16ClN3O, CAS 144514-38-5
3-(4-Acetyl-piperazin-1-yl)-4-chloroaniline
CAS 144514-38-5C12H16ClN3O
Piperazine, 1-pentyl-4-phenyl- chemical structure, C15H24N2, CAS 105746-14-3
Piperazine, 1-pentyl-4-phenyl-
CAS 105746-14-3C15H24N2
1-(2-Aminoethyl)-4-(2-methoxyphenyl)piperazine chemical structure, C13H21N3O, CAS 40255-48-9
1-(2-Aminoethyl)-4-(2-methoxyphenyl)piperazine
CAS 40255-48-9C13H21N3O
2-Chloro-1-[4-(2-cyanophenyl)piperazin-1-yl]ethanone chemical structure, C13H14ClN3O, CAS 177488-98-1
2-Chloro-1-[4-(2-cyanophenyl)piperazin-1-yl]ethanone
CAS 177488-98-1C13H14ClN3O
2-Chloro-4-(1-piperazinyl)phenol chemical structure, C10H13ClN2O, CAS 85474-76-6
2-Chloro-4-(1-piperazinyl)phenol
CAS 85474-76-6C10H13ClN2O
1-(2-Methoxy-5-nitrophenyl)-4-methylpiperazine chemical structure, C12H17N3O3, CAS 148547-50-6
1-(2-Methoxy-5-nitrophenyl)-4-methylpiperazine
CAS 148547-50-6C12H17N3O3
1-(3-Aminopropyl)-4-(2-methoxyphenyl)piperazine chemical structure, C14H23N3O, CAS 20529-23-1
1-(3-Aminopropyl)-4-(2-methoxyphenyl)piperazine
CAS 20529-23-1C14H23N3O
1-(2-Methoxy-4-methylphenyl)piperazine chemical structure, C12H18N2O, CAS 178672-02-1
1-(2-Methoxy-4-methylphenyl)piperazine
CAS 178672-02-1C12H18N2O
1-(4-Fluoro-2-methoxyphenyl)piperazine chemical structure, C11H15FN2O, CAS 102392-11-0
1-(4-Fluoro-2-methoxyphenyl)piperazine
CAS 102392-11-0C11H15FN2O
(S)-1-(3-Chlorophenyl)-3-methylpiperazine chemical structure, C11H15ClN2, CAS 203393-16-2
(S)-1-(3-Chlorophenyl)-3-methylpiperazine
CAS 203393-16-2C11H15ClN2
1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine chemical structure, C12H15F3N2O, CAS 178671-99-3
1-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazine
CAS 178671-99-3C12H15F3N2O
1-Piperazinepentanamide, 4-(2-methoxyphenyl)- chemical structure, C16H25N3O2, CAS 188708-21-6
1-Piperazinepentanamide, 4-(2-methoxyphenyl)-
CAS 188708-21-6C16H25N3O2