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Murcko scaffold

1-Phenylpiperazine scaffold

6,403 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
6,403
With full pages
595
Scaffold SMILES

c1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperazine page
Murcko scaffold c1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1,297 to 1,344 of 6,403 chemicals

tert-Butyl 4-(3-bromophenyl)piperazine-1-carboxylate chemical structure, C15H21BrN2O2, CAS 327030-39-7
tert-Butyl 4-(3-bromophenyl)piperazine-1-carboxylate
CAS 327030-39-7C15H21BrN2O2
Ethanone, 1-[2,5-difluoro-4-(3-methyl-1-piperazinyl)phenyl]- chemical structure, C13H16F2N2O, CAS 144647-64-3
Ethanone, 1-[2,5-difluoro-4-(3-methyl-1-piperazinyl)phenyl]-
CAS 144647-64-3C13H16F2N2O
1-(2,6-Difluorophenyl)piperazine chemical structure, C10H12F2N2, CAS 255893-56-2
1-(2,6-Difluorophenyl)piperazine
CAS 255893-56-2C10H12F2N2
Methyl 2-(piperazin-1-yl)benzoate chemical structure, C12H16N2O2, CAS 159974-63-7
Methyl 2-(piperazin-1-yl)benzoate
CAS 159974-63-7C12H16N2O2
tert-Butyl 4-(4-methoxyphenyl)piperazine-1-carboxylate chemical structure, C16H24N2O3, CAS 185460-26-8
tert-Butyl 4-(4-methoxyphenyl)piperazine-1-carboxylate
CAS 185460-26-8C16H24N2O3
1-[2-(Propan-2-yloxy)phenyl]piperazine chemical structure, C13H20N2O, CAS 54013-91-1
1-[2-(Propan-2-yloxy)phenyl]piperazine
CAS 54013-91-1C13H20N2O
1-(5-Chloro-2-fluoro-4-nitrophenyl)piperazine chemical structure, C10H11ClFN3O2, CAS 212694-66-1
1-(5-Chloro-2-fluoro-4-nitrophenyl)piperazine
CAS 212694-66-1C10H11ClFN3O2
Piperazine, 1-(4-fluorophenyl)-4-methyl- chemical structure, C11H15FN2, CAS 218940-68-2
Piperazine, 1-(4-fluorophenyl)-4-methyl-
CAS 218940-68-2C11H15FN2
1-Piperazineethanamine, 4-(2-chlorophenyl)- chemical structure, C12H18ClN3, CAS 55931-63-0
1-Piperazineethanamine, 4-(2-chlorophenyl)-
CAS 55931-63-0C12H18ClN3
1-(3-Methoxyphenyl)-4-methyl-piperazine chemical structure, C12H18N2O, CAS 57318-64-6
1-(3-Methoxyphenyl)-4-methyl-piperazine
CAS 57318-64-6C12H18N2O
4-(4-Propylpiperazin-1-yl)benzoic acid chemical structure, C14H20N2O2, CAS 85469-68-7
4-(4-Propylpiperazin-1-yl)benzoic acid
CAS 85469-68-7C14H20N2O2
1-(3,5-Difluorophenyl)piperazine chemical structure, C10H12F2N2, CAS 180698-14-0
1-(3,5-Difluorophenyl)piperazine
CAS 180698-14-0C10H12F2N2
1-(4-Aminobutyl)-4-(2-methoxyphenyl)piperazine chemical structure, C15H25N3O, CAS 21103-33-3
1-(4-Aminobutyl)-4-(2-methoxyphenyl)piperazine
CAS 21103-33-3C15H25N3O
2-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamine chemical structure, C12H18FN3, CAS 112822-55-6
2-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamine
CAS 112822-55-6C12H18FN3
4-[4-(2-Fluoroethyl)-1-piperazinyl]benzenamine chemical structure, C12H18FN3, CAS 630419-22-6
4-[4-(2-Fluoroethyl)-1-piperazinyl]benzenamine
CAS 630419-22-6C12H18FN3
tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate chemical structure, C15H23N3O2, CAS 170911-92-9
tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate
CAS 170911-92-9C15H23N3O2
3-(4-Methylpiperazin-1-yl)phenol chemical structure, C11H16N2O, CAS 177489-10-0
3-(4-Methylpiperazin-1-yl)phenol
CAS 177489-10-0C11H16N2O
(4-Piperazin-1-ylphenyl)acetonitrile chemical structure, C12H15N3, CAS 868244-47-7
(4-Piperazin-1-ylphenyl)acetonitrile
CAS 868244-47-7C12H15N3
4-(4-Ethylpiperazino)benzonitrile chemical structure, C13H17N3, CAS 186650-78-2
4-(4-Ethylpiperazino)benzonitrile
CAS 186650-78-2C13H17N3
[2-(Piperazin-1-yl)phenyl]methanamine chemical structure, C11H17N3, CAS 190017-89-1
[2-(Piperazin-1-yl)phenyl]methanamine
CAS 190017-89-1C11H17N3
Piperazine, 1-methyl-4-[3-(trifluoromethyl)phenyl]- chemical structure, C12H15F3N2, CAS 74418-11-4
Piperazine, 1-methyl-4-[3-(trifluoromethyl)phenyl]-
CAS 74418-11-4C12H15F3N2
1-[4-(3-Nitrophenyl)piperazin-1-yl]ethan-1-one chemical structure, C12H15N3O3, CAS 314061-17-1
1-[4-(3-Nitrophenyl)piperazin-1-yl]ethan-1-one
CAS 314061-17-1C12H15N3O3
3-Methyl-1-(4-methylphenyl)piperazine chemical structure, C12H18N2, CAS 180622-24-6
3-Methyl-1-(4-methylphenyl)piperazine
CAS 180622-24-6C12H18N2
N-(3-Piperazin-1-ylphenyl)methanesulfonamide chemical structure, C11H17N3O2S, CAS 500882-30-4
N-(3-Piperazin-1-ylphenyl)methanesulfonamide
CAS 500882-30-4C11H17N3O2S