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Murcko scaffold

1-Phenylpiperazine scaffold

6,403 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
6,403
With full pages
595
Scaffold SMILES

c1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperazine page
Murcko scaffold c1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1,345 to 1,392 of 6,403 chemicals

1-Piperazinebutanoic acid, 4-(2-methoxyphenyl)- chemical structure, C15H22N2O3, CAS 824958-22-7
1-Piperazinebutanoic acid, 4-(2-methoxyphenyl)-
CAS 824958-22-7C15H22N2O3
3-[4-(2-Fluorophenyl)piperazin-1-yl]propane-1-sulfonic acid chemical structure, C13H19FN2O3S, CAS 720698-89-5
3-[4-(2-Fluorophenyl)piperazin-1-yl]propane-1-sulfonic acid
CAS 720698-89-5C13H19FN2O3S
1-(2,4,5-Trifluorophenyl)piperazine chemical structure, C10H11F3N2, CAS 255893-34-6
1-(2,4,5-Trifluorophenyl)piperazine
CAS 255893-34-6C10H11F3N2
3-Bromo-4-(4-methylpiperazin-1-yl)benzaldehyde chemical structure, C12H15BrN2O, CAS 443777-03-5
3-Bromo-4-(4-methylpiperazin-1-yl)benzaldehyde
CAS 443777-03-5C12H15BrN2O
1-Boc-4-(4-Bromo-2-formylphenyl)piperazine chemical structure, C16H21BrN2O3, CAS 628326-05-6
1-Boc-4-(4-Bromo-2-formylphenyl)piperazine
CAS 628326-05-6C16H21BrN2O3
3-Fluoro-5-(piperazin-1-yl)benzonitrile chemical structure, C11H12FN3, CAS 752967-51-4
3-Fluoro-5-(piperazin-1-yl)benzonitrile
CAS 752967-51-4C11H12FN3
1-[3-Fluoro-5-(trifluoromethyl)phenyl]-piperazine chemical structure, C11H12F4N2, CAS 210992-82-8
1-[3-Fluoro-5-(trifluoromethyl)phenyl]-piperazine
CAS 210992-82-8C11H12F4N2
1-Piperazinebutanamine, 4-(3-chloro-2-methoxyphenyl)- chemical structure, C15H24ClN3O, CAS 854411-89-5
1-Piperazinebutanamine, 4-(3-chloro-2-methoxyphenyl)-
CAS 854411-89-5C15H24ClN3O
trans-4-(2,5-Dimethylpiperazin-1-yl)-2-trifluoromethylbenzonitrile chemical structure, C14H16F3N3, CAS 262295-56-7
trans-4-(2,5-Dimethylpiperazin-1-yl)-2-trifluoromethylbenzonitrile
CAS 262295-56-7C14H16F3N3
2-Bromo-5-(4-methyl-piperazin-1-yl)-benzaldehyde chemical structure, C12H15BrN2O, CAS 628325-61-1
2-Bromo-5-(4-methyl-piperazin-1-yl)-benzaldehyde
CAS 628325-61-1C12H15BrN2O
1-(4-Bromophenyl)-4-isopropylpiperazine chemical structure, C13H19BrN2, CAS 844431-60-3
1-(4-Bromophenyl)-4-isopropylpiperazine
CAS 844431-60-3C13H19BrN2
4-Piperazin-1-YL-2-trifluoromethyl-benzonitrile hydrochloride chemical structure, C12H13ClF3N3, CAS 824409-64-5
4-Piperazin-1-YL-2-trifluoromethyl-benzonitrile hydrochloride
CAS 824409-64-5C12H13ClF3N3
4-(Piperazin-1-yl)-2-(trifluoromethyl)benzonitrile chemical structure, C12H12F3N3, CAS 262295-57-8
4-(Piperazin-1-yl)-2-(trifluoromethyl)benzonitrile
CAS 262295-57-8C12H12F3N3
Piperazine, 1-cyano-4-[3-(trifluoromethyl)phenyl]- chemical structure, C12H12F3N3, CAS 827322-76-9
Piperazine, 1-cyano-4-[3-(trifluoromethyl)phenyl]-
CAS 827322-76-9C12H12F3N3
1-(4-Chlorophenyl)-4-(3-chloropropyl)piperazine dihydrochloride chemical structure, C13H20Cl4N2, CAS 875304-69-1
1-(4-Chlorophenyl)-4-(3-chloropropyl)piperazine dihydrochloride
CAS 875304-69-1C13H20Cl4N2
1-(3-Bromo-5-fluorophenyl)piperazine chemical structure, C10H12BrFN2, CAS 852807-43-3
1-(3-Bromo-5-fluorophenyl)piperazine
CAS 852807-43-3C10H12BrFN2
1-(3-Cyanophenyl)piperazine chemical structure, C11H13N3, CAS 178928-58-0
1-(3-Cyanophenyl)piperazine
CAS 178928-58-0C11H13N3
1-[4-(2-Fluoroethoxy)phenyl]piperazine chemical structure, C12H17FN2O, CAS 913734-75-5
1-[4-(2-Fluoroethoxy)phenyl]piperazine
CAS 913734-75-5C12H17FN2O
1-(2,6-Dichlorophenyl)piperazine chemical structure, C10H12Cl2N2, CAS 63386-61-8
1-(2,6-Dichlorophenyl)piperazine
CAS 63386-61-8C10H12Cl2N2
(2R)-1-(3,5-Difluorophenyl)-2-methylpiperazine chemical structure, C11H14F2N2, CAS 845740-74-1
(2R)-1-(3,5-Difluorophenyl)-2-methylpiperazine
CAS 845740-74-1C11H14F2N2
Ethyl 3-(piperazin-1-yl)benzoate chemical structure, C13H18N2O2, CAS 202262-40-6
Ethyl 3-(piperazin-1-yl)benzoate
CAS 202262-40-6C13H18N2O2
tert-Butyl 4-(2-chloro-6-formylphenyl)piperazine-1-carboxylate chemical structure, C16H21ClN2O3, CAS 869478-15-9
tert-Butyl 4-(2-chloro-6-formylphenyl)piperazine-1-carboxylate
CAS 869478-15-9C16H21ClN2O3
1-(4-Bromophenyl)-2,5-dimethylpiperazine chemical structure, C12H17BrN2, CAS 1467861-84-2
1-(4-Bromophenyl)-2,5-dimethylpiperazine
CAS 1467861-84-2C12H17BrN2
tert-Butyl 4-(4-bromo-2-nitrophenyl)piperazine-1-carboxylate chemical structure, C15H20BrN3O4, CAS 474329-57-2
tert-Butyl 4-(4-bromo-2-nitrophenyl)piperazine-1-carboxylate
CAS 474329-57-2C15H20BrN3O4