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Murcko scaffold

1-Phenylpiperazine scaffold

6,403 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
6,403
With full pages
595
Scaffold SMILES

c1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperazine page
Murcko scaffold c1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1,393 to 1,440 of 6,403 chemicals

Methyl 3-amino-5-(4-methyl-1-piperazinyl)-2-nitrobenzoate chemical structure, C13H18N4O4, CAS 874301-33-4
Methyl 3-amino-5-(4-methyl-1-piperazinyl)-2-nitrobenzoate
CAS 874301-33-4C13H18N4O4
1-(3-Chloropropyl)-4-phenylpiperazine hydrochloride chemical structure, C13H20Cl2N2, CAS 79145-33-8
1-(3-Chloropropyl)-4-phenylpiperazine hydrochloride
CAS 79145-33-8C13H20Cl2N2
1-(2-Chloroethyl)-4-phenylpiperazine dihydrochloride chemical structure, C12H19Cl3N2, CAS 36245-28-0
1-(2-Chloroethyl)-4-phenylpiperazine dihydrochloride
CAS 36245-28-0C12H19Cl3N2
1-[4-(2-Hydroxyphenyl)piperazin-1-yl]-2,2-dimethylpropan-1-one chemical structure, C15H22N2O2, CAS 1027066-16-5
1-[4-(2-Hydroxyphenyl)piperazin-1-yl]-2,2-dimethylpropan-1-one
CAS 1027066-16-5C15H22N2O2
1-(2-Chloroethyl)-4-(4-nitrophenyl)piperazine chemical structure, C12H16ClN3O2, CAS 710272-54-1
1-(2-Chloroethyl)-4-(4-nitrophenyl)piperazine
CAS 710272-54-1C12H16ClN3O2
4-(4-(2-Chloroacetyl)piperazin-1-yl)benzonitrile chemical structure, C13H14ClN3O, CAS 1025873-62-4
4-(4-(2-Chloroacetyl)piperazin-1-yl)benzonitrile
CAS 1025873-62-4C13H14ClN3O
1-(5-Chloro-4-fluoro-2-nitrophenyl)piperazine chemical structure, C10H11ClFN3O2, CAS 212694-68-3
1-(5-Chloro-4-fluoro-2-nitrophenyl)piperazine
CAS 212694-68-3C10H11ClFN3O2
1-(3-Fluorophenyl)-4-methylpiperazine chemical structure, C11H15FN2, CAS 218940-66-0
1-(3-Fluorophenyl)-4-methylpiperazine
CAS 218940-66-0C11H15FN2
1-(3-Bromo-4-nitrophenyl)-4-methylpiperazine chemical structure, C11H14BrN3O2, CAS 166818-85-5
1-(3-Bromo-4-nitrophenyl)-4-methylpiperazine
CAS 166818-85-5C11H14BrN3O2
1-N-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine chemical structure, C16H21N3O6, CAS 183622-36-8
1-N-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine
CAS 183622-36-8C16H21N3O6
1-(3-Chloro-5-fluorophenyl)piperazine chemical structure, C10H12ClFN2, CAS 210992-23-7
1-(3-Chloro-5-fluorophenyl)piperazine
CAS 210992-23-7C10H12ClFN2
1-(4-Bromophenyl)-4-methylpiperazine chemical structure, C11H15BrN2, CAS 130307-08-3
1-(4-Bromophenyl)-4-methylpiperazine
CAS 130307-08-3C11H15BrN2
tert-Butyl 4-(4-bromophenyl)piperazine-1-carboxylate chemical structure, C15H21BrN2O2, CAS 352437-09-3
tert-Butyl 4-(4-bromophenyl)piperazine-1-carboxylate
CAS 352437-09-3C15H21BrN2O2
1-(2-Methoxy-4-nitrophenyl)-4-methylpiperazine chemical structure, C12H17N3O3, CAS 209482-01-9
1-(2-Methoxy-4-nitrophenyl)-4-methylpiperazine
CAS 209482-01-9C12H17N3O3
3-Methoxy-4-(4-methylpiperazin-1-yl)aniline chemical structure, C12H19N3O, CAS 156428-85-2
3-Methoxy-4-(4-methylpiperazin-1-yl)aniline
CAS 156428-85-2C12H19N3O
1-(3-Chlorophenyl)piperazine dihydrochloride chemical structure, C10H15Cl3N2, CAS 51639-49-7
1-(3-Chlorophenyl)piperazine dihydrochloride
CAS 51639-49-7C10H15Cl3N2
4-(4-Fluorophenyl)-alpha-methylpiperazine-1-propylamine chemical structure, C14H22FN3, CAS 27367-89-1
4-(4-Fluorophenyl)-alpha-methylpiperazine-1-propylamine
CAS 27367-89-1C14H22FN3
1-Piperazineethanol, alpha-(((1-methylethyl)amino)methyl)-4-phenyl-, hydrochloride chemical structure, C16H28ClN3O, CAS 104317-88-6
1-Piperazineethanol, alpha-(((1-methylethyl)amino)methyl)-4-phenyl-, hydrochloride
CAS 104317-88-6C16H28ClN3O
4-[3-(Trifluoromethoxy)phenyl]-1-piperazineethanol chemical structure, C13H17F3N2O2, CAS 51941-11-8
4-[3-(Trifluoromethoxy)phenyl]-1-piperazineethanol
CAS 51941-11-8C13H17F3N2O2
4-(4-Methyl-1-piperazinyl)benzeneethanol chemical structure, C13H20N2O, CAS 1368970-72-2
4-(4-Methyl-1-piperazinyl)benzeneethanol
CAS 1368970-72-2C13H20N2O
1-(2-Bromophenyl)-4-methylpiperazine chemical structure, C11H15BrN2, CAS 250383-81-4
1-(2-Bromophenyl)-4-methylpiperazine
CAS 250383-81-4C11H15BrN2
1-(2-Chloroethyl)-4-(3,4-dichlorophenyl)piperazine chemical structure, C12H15Cl3N2, CAS 199617-03-3
1-(2-Chloroethyl)-4-(3,4-dichlorophenyl)piperazine
CAS 199617-03-3C12H15Cl3N2
1-(4-Methoxyphenyl)-3-methylpiperazine chemical structure, C12H18N2O, CAS 482308-72-5
1-(4-Methoxyphenyl)-3-methylpiperazine
CAS 482308-72-5C12H18N2O
(3R,5S)-1-(3-Methoxyphenyl)-3,5-dimethylpiperazine chemical structure, C13H20N2O, CAS 482308-77-0
(3R,5S)-1-(3-Methoxyphenyl)-3,5-dimethylpiperazine
CAS 482308-77-0C13H20N2O