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Murcko scaffold

1-Phenylpiperazine scaffold

6,403 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
6,403
With full pages
595
Scaffold SMILES

c1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperazine page
Murcko scaffold c1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1,441 to 1,488 of 6,403 chemicals

N-(3-Methoxyphenyl)piperazine hydrochloride chemical structure, C11H17ClN2O, CAS 16015-70-6
N-(3-Methoxyphenyl)piperazine hydrochloride
CAS 16015-70-6C11H17ClN2O
4-Phenylpiperazine-1-carbonitrile chemical structure, C11H13N3, CAS 77464-04-1
4-Phenylpiperazine-1-carbonitrile
CAS 77464-04-1C11H13N3
2-Amino-6-(4-methylpiperazin-1-yl)benzonitrile chemical structure, C12H16N4, CAS 63365-17-3
2-Amino-6-(4-methylpiperazin-1-yl)benzonitrile
CAS 63365-17-3C12H16N4
Acetic acid, 2-[[2-cyano-3-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxo-, ethyl ester, hydrochloride (1:1) chemical structure, C16H21ClN4O3, CAS 63365-18-4
Acetic acid, 2-[[2-cyano-3-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxo-, ethyl ester, hydrochloride (1:1)
CAS 63365-18-4C16H21ClN4O3
2-(4-Methylpiperazin-1-yl)-6-nitrobenzonitrile chemical structure, C12H14N4O2, CAS 63365-16-2
2-(4-Methylpiperazin-1-yl)-6-nitrobenzonitrile
CAS 63365-16-2C12H14N4O2
2-(4-(3-Chlorophenyl)piperazin-1-yl)ethan-1-amine chemical structure, C12H18ClN3, CAS 21103-30-0
2-(4-(3-Chlorophenyl)piperazin-1-yl)ethan-1-amine
CAS 21103-30-0C12H18ClN3
3-[4-(3-Chlorophenyl)piperazin-1-yl]propanenitrile chemical structure, C13H16ClN3, CAS 48167-19-7
3-[4-(3-Chlorophenyl)piperazin-1-yl]propanenitrile
CAS 48167-19-7C13H16ClN3
3-[4-(4-Chlorophenyl)piperazin-1-yl]propanenitrile chemical structure, C13H16ClN3, CAS 79322-92-2
3-[4-(4-Chlorophenyl)piperazin-1-yl]propanenitrile
CAS 79322-92-2C13H16ClN3
4-(3-Methylphenyl)-1-piperazinepropanamine chemical structure, C14H23N3, CAS 20529-22-0
4-(3-Methylphenyl)-1-piperazinepropanamine
CAS 20529-22-0C14H23N3
{3-[4-(4-Methylphenyl)piperazin-1-yl]propyl}amine chemical structure, C14H23N3, CAS 40255-47-8
{3-[4-(4-Methylphenyl)piperazin-1-yl]propyl}amine
CAS 40255-47-8C14H23N3
3-[4-(2-Chlorophenyl)piperazin-1-yl]propan-1-amine chemical structure, C13H20ClN3, CAS 55931-64-1
3-[4-(2-Chlorophenyl)piperazin-1-yl]propan-1-amine
CAS 55931-64-1C13H20ClN3
1-Amino-3-[4-(4-chlorophenyl)-1-piperazinyl]propane chemical structure, C13H20ClN3, CAS 79322-93-3
1-Amino-3-[4-(4-chlorophenyl)-1-piperazinyl]propane
CAS 79322-93-3C13H20ClN3
3-(4-Acetyl-piperazin-1-yl)-4-fluoroaniline chemical structure, C12H16FN3O, CAS 75001-84-2
3-(4-Acetyl-piperazin-1-yl)-4-fluoroaniline
CAS 75001-84-2C12H16FN3O
4-Phenylpiperazin-1-amine chemical structure, C10H15N3, CAS 14340-32-0
4-Phenylpiperazin-1-amine
CAS 14340-32-0C10H15N3
4-[4-(3-Chloropropyl)-1-piperazinyl]benzonitrile chemical structure, C14H18ClN3, CAS 79144-83-5
4-[4-(3-Chloropropyl)-1-piperazinyl]benzonitrile
CAS 79144-83-5C14H18ClN3
1-(2,5-Dichlorophenyl)piperazine hydrochloride chemical structure, C10H13Cl3N2, CAS 119438-13-0
1-(2,5-Dichlorophenyl)piperazine hydrochloride
CAS 119438-13-0C10H13Cl3N2
4-(3-Chlorophenyl)-1-piperazinepropanoic acid hydrazide chemical structure, C13H19ClN4O, CAS 72822-17-4
4-(3-Chlorophenyl)-1-piperazinepropanoic acid hydrazide
CAS 72822-17-4C13H19ClN4O
Ethyl 1-(2-cyano-4-nitrophenyl)-4-methyl-2-piperazinecarboxylate chemical structure, C15H18N4O4, CAS 85147-16-6
Ethyl 1-(2-cyano-4-nitrophenyl)-4-methyl-2-piperazinecarboxylate
CAS 85147-16-6C15H18N4O4
1-(3,4-Dimethoxyphenyl)piperazine hydrochloride chemical structure, C12H19ClN2O2, CAS 16015-72-8
1-(3,4-Dimethoxyphenyl)piperazine hydrochloride
CAS 16015-72-8C12H19ClN2O2
4-[4-(3-Chlorophenyl)piperazin-1-yl]butan-1-amine chemical structure, C14H22ClN3, CAS 116331-14-7
4-[4-(3-Chlorophenyl)piperazin-1-yl]butan-1-amine
CAS 116331-14-7C14H22ClN3
1-(4-Methoxyphenyl)-4-propylpiperazine chemical structure, C14H22N2O, CAS 79072-41-6
1-(4-Methoxyphenyl)-4-propylpiperazine
CAS 79072-41-6C14H22N2O
1-(4-Methoxyphenyl)-4-(propan-2-yl)piperazine chemical structure, C14H22N2O, CAS 84499-46-7
1-(4-Methoxyphenyl)-4-(propan-2-yl)piperazine
CAS 84499-46-7C14H22N2O
1-(3-Hydroxyphenyl)-4-ethoxycarbonyl-piperazine chemical structure, C13H18N2O3, CAS 67915-01-9
1-(3-Hydroxyphenyl)-4-ethoxycarbonyl-piperazine
CAS 67915-01-9C13H18N2O3
1-Acetyl-4-(3-hydroxyphenyl)piperazine chemical structure, C12H16N2O2, CAS 67915-02-0
1-Acetyl-4-(3-hydroxyphenyl)piperazine
CAS 67915-02-0C12H16N2O2