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Murcko scaffold

1-Phenylpiperazine scaffold

6,403 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
6,403
With full pages
595
Scaffold SMILES

c1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperazine page
Murcko scaffold c1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1,489 to 1,536 of 6,403 chemicals

1-(4-Chlorophenyl)-4-{2-[(trimethylsilyl)oxy]ethyl}piperazine chemical structure, C15H25ClN2OSi, CAS 89841-33-8
1-(4-Chlorophenyl)-4-{2-[(trimethylsilyl)oxy]ethyl}piperazine
CAS 89841-33-8C15H25ClN2OSi
1-(3-Chlorophenyl)-4-{2-[(trimethylsilyl)oxy]ethyl}piperazine chemical structure, C15H25ClN2OSi, CAS 89841-34-9
1-(3-Chlorophenyl)-4-{2-[(trimethylsilyl)oxy]ethyl}piperazine
CAS 89841-34-9C15H25ClN2OSi
1-(2-Methylphenyl)-4-{2-[(trimethylsilyl)oxy]ethyl}piperazine chemical structure, C16H28N2OSi, CAS 89871-88-5
1-(2-Methylphenyl)-4-{2-[(trimethylsilyl)oxy]ethyl}piperazine
CAS 89871-88-5C16H28N2OSi
1-Phenyl-4-{2-[(trimethylsilyl)oxy]ethyl}piperazine chemical structure, C15H26N2OSi, CAS 89841-35-0
1-Phenyl-4-{2-[(trimethylsilyl)oxy]ethyl}piperazine
CAS 89841-35-0C15H26N2OSi
1-(3-Chloro-4-fluorophenyl)-4-(3-chloropropyl)piperazine chemical structure, C13H17Cl2FN2, CAS 91532-32-0
1-(3-Chloro-4-fluorophenyl)-4-(3-chloropropyl)piperazine
CAS 91532-32-0C13H17Cl2FN2
4-[4-(3-Methylphenyl)piperazin-1-yl]butan-1-amine chemical structure, C15H25N3, CAS 90931-05-8
4-[4-(3-Methylphenyl)piperazin-1-yl]butan-1-amine
CAS 90931-05-8C15H25N3
4-(Piperazin-1-yl)benzene-1,2-diamine chemical structure, C10H16N4, CAS 96103-60-5
4-(Piperazin-1-yl)benzene-1,2-diamine
CAS 96103-60-5C10H16N4
Phosphonochloridic acid, [4-(2-chlorophenyl)-1-piperazinyl]-, ethyl ester chemical structure, C12H17Cl2N2O2P, CAS 98156-28-6
Phosphonochloridic acid, [4-(2-chlorophenyl)-1-piperazinyl]-, ethyl ester
CAS 98156-28-6C12H17Cl2N2O2P
4-(4-Iodophenyl)-1-piperazinecarboximidamide chemical structure, C11H15IN4, CAS 96530-60-8
4-(4-Iodophenyl)-1-piperazinecarboximidamide
CAS 96530-60-8C11H15IN4
2-(4-(4-Fluorophenyl)piperazin-1-yl)ethan-1-ol chemical structure, C12H17FN2O, CAS 90096-38-1
2-(4-(4-Fluorophenyl)piperazin-1-yl)ethan-1-ol
CAS 90096-38-1C12H17FN2O
2-Fluoro-6-(4-methylpiperazinyl)benzonitrile chemical structure, C12H14FN3, CAS 96783-86-7
2-Fluoro-6-(4-methylpiperazinyl)benzonitrile
CAS 96783-86-7C12H14FN3
tert-Butyl 4-(2-methoxyphenyl)piperazine-1-carboxylate chemical structure, C16H24N2O3, CAS 95520-98-2
tert-Butyl 4-(2-methoxyphenyl)piperazine-1-carboxylate
CAS 95520-98-2C16H24N2O3
1-Piperazinecarboxylic acid, 4-(2-methoxyphenyl)-, 1,1-dimethylethyl ester, 4-oxide chemical structure, C16H24N2O4, CAS 95520-99-3
1-Piperazinecarboxylic acid, 4-(2-methoxyphenyl)-, 1,1-dimethylethyl ester, 4-oxide
CAS 95520-99-3C16H24N2O4
1-(2-Methoxyphenyl)-1-oxo-1lambda~5~-piperazine chemical structure, C11H16N2O2, CAS 62845-28-7
1-(2-Methoxyphenyl)-1-oxo-1lambda~5~-piperazine
CAS 62845-28-7C11H16N2O2
4-(4-Methylpiperazin-1-yl)benzenethiol chemical structure, C11H16N2S, CAS 106365-89-3
4-(4-Methylpiperazin-1-yl)benzenethiol
CAS 106365-89-3C11H16N2S
3-Chloro-4-(piperazin-1-yl)phenol chemical structure, C10H13ClN2O, CAS 1484808-34-5
3-Chloro-4-(piperazin-1-yl)phenol
CAS 1484808-34-5C10H13ClN2O
3-(4-Methylpiperazin-1-yl)-5-nitrobenzenamine chemical structure, C11H16N4O2, CAS 106050-89-9
3-(4-Methylpiperazin-1-yl)-5-nitrobenzenamine
CAS 106050-89-9C11H16N4O2
4-Piperazin-1-ylbenzaldehyde chemical structure, C11H14N2O, CAS 27913-98-0
4-Piperazin-1-ylbenzaldehyde
CAS 27913-98-0C11H14N2O
1-(4-Isothiocyanatophenyl)-4-methylpiperazine chemical structure, C12H15N3S, CAS 23861-85-0
1-(4-Isothiocyanatophenyl)-4-methylpiperazine
CAS 23861-85-0C12H15N3S
1-Isobutyl-4-(4-iodophenyl)piperazine chemical structure, C14H21IN2, CAS 1014987-50-8
1-Isobutyl-4-(4-iodophenyl)piperazine
CAS 1014987-50-8C14H21IN2
4-(2-Methoxyphenyl)piperazin-1-amine chemical structure, C11H17N3O, CAS 19351-48-5
4-(2-Methoxyphenyl)piperazin-1-amine
CAS 19351-48-5C11H17N3O
4-(2-Methylpiperazin-1-yl)phenol chemical structure, C11H16N2O, CAS 733699-84-8
4-(2-Methylpiperazin-1-yl)phenol
CAS 733699-84-8C11H16N2O
1-(2-Fluoroethyl)-4-phenylpiperazine chemical structure, C12H17FN2, CAS 106114-50-5
1-(2-Fluoroethyl)-4-phenylpiperazine
CAS 106114-50-5C12H17FN2
Ethyl 3-[4-(3-methoxyphenyl)piperazin-1-yl]propanoate chemical structure, C16H24N2O3, CAS 63854-03-5
Ethyl 3-[4-(3-methoxyphenyl)piperazin-1-yl]propanoate
CAS 63854-03-5C16H24N2O3