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Murcko scaffold

1-Phenylpiperazine scaffold

6,403 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
6,403
With full pages
595
Scaffold SMILES

c1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperazine page
Murcko scaffold c1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1,537 to 1,584 of 6,403 chemicals

4-[4-(4-Fluorophenyl)piperazin-1-yl]butanoic acid chemical structure, C14H19FN2O2, CAS 130933-46-9
4-[4-(4-Fluorophenyl)piperazin-1-yl]butanoic acid
CAS 130933-46-9C14H19FN2O2
2-(4-Phenylpiperazin-1-yl)ethyl 3-oxobutanoate chemical structure, C16H22N2O3, CAS 90096-28-9
2-(4-Phenylpiperazin-1-yl)ethyl 3-oxobutanoate
CAS 90096-28-9C16H22N2O3
2-[4-(2-Methylphenyl)piperazin-1-yl]ethyl 3-oxobutanoate chemical structure, C17H24N2O3, CAS 90096-27-8
2-[4-(2-Methylphenyl)piperazin-1-yl]ethyl 3-oxobutanoate
CAS 90096-27-8C17H24N2O3
2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl 3-oxobutanoate chemical structure, C16H21ClN2O3, CAS 90096-26-7
2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl 3-oxobutanoate
CAS 90096-26-7C16H21ClN2O3
1-(2-Methoxyphenyl)-2-methylpiperazine chemical structure, C12H18N2O, CAS 893750-19-1
1-(2-Methoxyphenyl)-2-methylpiperazine
CAS 893750-19-1C12H18N2O
Piperazine, 1-(3-chlorophenyl)-4-methyl- chemical structure, C11H15ClN2, CAS 20011-11-4
Piperazine, 1-(3-chlorophenyl)-4-methyl-
CAS 20011-11-4C11H15ClN2
1-(3-Chlorophenyl)-4-propylpiperazine chemical structure, C13H19ClN2, CAS 144146-59-8
1-(3-Chlorophenyl)-4-propylpiperazine
CAS 144146-59-8C13H19ClN2
1-(3-Chlorophenyl)-4-octylpiperazine chemical structure, C18H29ClN2, CAS 141510-99-8
1-(3-Chlorophenyl)-4-octylpiperazine
CAS 141510-99-8C18H29ClN2
3-Methoxy-4-(piperazin-1-yl)phenol chemical structure, C11H16N2O2, CAS 129338-90-5
3-Methoxy-4-(piperazin-1-yl)phenol
CAS 129338-90-5C11H16N2O2
4-(2-Ethoxyphenyl)-1-piperazineethanol chemical structure, C14H22N2O2, CAS 40004-30-6
4-(2-Ethoxyphenyl)-1-piperazineethanol
CAS 40004-30-6C14H22N2O2
tert-Butyl 4-(4-fluorophenyl)piperazine-1-carboxylate chemical structure, C15H21FN2O2, CAS 141940-39-8
tert-Butyl 4-(4-fluorophenyl)piperazine-1-carboxylate
CAS 141940-39-8C15H21FN2O2
5-{4-[(tert-Butoxy)carbonyl]piperazin-1-yl}-2-fluorobenzoic acid chemical structure, C16H21FN2O4, CAS 141940-35-4
5-{4-[(tert-Butoxy)carbonyl]piperazin-1-yl}-2-fluorobenzoic acid
CAS 141940-35-4C16H21FN2O4
4-(4-Acetylpiperazin-1-yl)phenyl acetate chemical structure, C14H18N2O3, CAS 133345-21-8
4-(4-Acetylpiperazin-1-yl)phenyl acetate
CAS 133345-21-8C14H18N2O3
4-(4-Hydroxyphenyl)piperazine-1-carbaldehyde chemical structure, C11H14N2O2, CAS 112190-13-3
4-(4-Hydroxyphenyl)piperazine-1-carbaldehyde
CAS 112190-13-3C11H14N2O2
1-(2-Chloro-3-methylphenyl)piperazine chemical structure, C11H15ClN2, CAS 129722-29-8
1-(2-Chloro-3-methylphenyl)piperazine
CAS 129722-29-8C11H15ClN2
1-(2-Bromo-3-methylphenyl)piperazine chemical structure, C11H15BrN2, CAS 129722-31-2
1-(2-Bromo-3-methylphenyl)piperazine
CAS 129722-31-2C11H15BrN2
4-(2-Methoxy-5-trifluoromethyl-phenyl)-piperazine chemical structure, C12H15F3N2O, CAS 178974-29-3
4-(2-Methoxy-5-trifluoromethyl-phenyl)-piperazine
CAS 178974-29-3C12H15F3N2O
1-(3-Bromopropyl)-4-(3-chlorophenyl)piperazine chemical structure, C13H18BrClN2, CAS 142944-48-7
1-(3-Bromopropyl)-4-(3-chlorophenyl)piperazine
CAS 142944-48-7C13H18BrClN2
4-[4-(4-Chlorophenyl)piperazin-1-yl]butan-1-amine chemical structure, C14H22ClN3, CAS 92328-97-7
4-[4-(4-Chlorophenyl)piperazin-1-yl]butan-1-amine
CAS 92328-97-7C14H22ClN3
3-{4-[3-(Trifluoromethyl)phenyl]piperazin-1-yl}propan-1-amine chemical structure, C14H20F3N3, CAS 20529-25-3
3-{4-[3-(Trifluoromethyl)phenyl]piperazin-1-yl}propan-1-amine
CAS 20529-25-3C14H20F3N3
4-(2-Methylphenyl)piperazin-1-amine chemical structure, C11H17N3, CAS 184034-77-3
4-(2-Methylphenyl)piperazin-1-amine
CAS 184034-77-3C11H17N3
4-(4-Methylphenyl)piperazin-1-amine chemical structure, C11H17N3, CAS 184034-78-4
4-(4-Methylphenyl)piperazin-1-amine
CAS 184034-78-4C11H17N3
1-(5-Methyl-2-nitrophenyl)piperazine chemical structure, C11H15N3O2, CAS 192441-83-1
1-(5-Methyl-2-nitrophenyl)piperazine
CAS 192441-83-1C11H15N3O2
1-(3-Methyl-4-nitrophenyl)piperazine chemical structure, C11H15N3O2, CAS 192441-84-2
1-(3-Methyl-4-nitrophenyl)piperazine
CAS 192441-84-2C11H15N3O2