Browse by ring system
Murcko scaffolds
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: its rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
- Scaffolds with a page
- 15.8K
- Distinct scaffolds computed
- 545.2K
Scaffolds with the most chemicals
Each scaffold here is shared by at least 3 chemicals with full pages. Very common single rings such as benzene and pyridine are left out.
Showing 2,941 to 3,000 of 15,838 scaffolds
4,5-Diphenyl-1,3-thiazole11 chemicals, 3 rings
O=C(OC1CCNC1)C(c1ccccc1)C1CCCC111 chemicals, 3 rings
O=C(CS(=O)c1ccccc1)Nc1ccccc111 chemicals, 2 rings
2-[[4-(Furan-2-carbonyl)piperazin-1-yl]methyl]-5-phenylmethoxypyran-4-one11 chemicals, 4 rings
C1CCN(C2CCC3CCC4C5CC(N6CCCCC6)CC5CCC4C3C2)CC111 chemicals, 6 rings![Scaffold c1ncc(C2CC2)[nH]1](/scaffold/BNFGUBCFRVUHJH-UHFFFAOYSA-N/structure.svg)
5-Cyclopropyl-1H-imidazole11 chemicals, 2 rings
4-Benzyl-1,3-dihydroquinoxalin-2-one11 chemicals, 3 rings
Pyrido(3,2-d)pyrimidine11 chemicals, 2 rings
O=C(COc1cccc2ccccc12)NN=Cc1ccc(OC(=O)c2ccccc2)cc111 chemicals, 4 rings
N-{2-Oxo-1-azatricyclo[6.3.1.0^{4,12}]dodeca-4,6,8(12)-trien-6-yl}benzamide11 chemicals, 4 rings
O=C(CN(c1ccccc1)S(=O)(=O)c1ccsc1)Nc1ccccc111 chemicals, 3 rings
O=C(NN1CCNCC1)c1ccccc111 chemicals, 2 rings![Scaffold O=C(CN1CCCCC1)c1c[nH]c2ccccc12](/scaffold/CDRQAUBCVZVLOJ-UHFFFAOYSA-N/structure.svg)
1-(1H-Indol-3-yl)-2-(1-piperidinyl)ethanone11 chemicals, 3 rings![Scaffold O=c1c(-c2nc3ccccc3[nH]2)coc2ccccc12](/scaffold/CDTPMSJYRHCMBU-UHFFFAOYSA-N/structure.svg)
O=c1c(-c2nc3ccccc3[nH]2)coc2ccccc1211 chemicals, 4 rings![Scaffold O=C(CSc1ncc[nH]1)c1ccccc1](/scaffold/CEDDMTUHVWGQAC-UHFFFAOYSA-N/structure.svg)
2-(1H-Imidazol-2-ylsulfanyl)-1-phenylethan-1-one11 chemicals, 2 rings![Scaffold O=c1[nH]cnnc1Cc1ccccc1](/scaffold/CHTMFHHNNMMCAN-UHFFFAOYSA-N/structure.svg)
O=c1[nH]cnnc1Cc1ccccc111 chemicals, 2 rings
Benzoic acid biphenyl-4-yl ester11 chemicals, 3 rings
N-(5-Phenyl-1,3,4-oxadiazol-2-yl)-5,6-dihydro-1,4-dioxine-2-carboxamide11 chemicals, 3 rings
O=C(C1=CC(=O)N(Cc2cccnc2)C1c1ccccc1)c1cccs111 chemicals, 4 rings
C(=NN1CCN(c2ccccn2)CC1)c1ccccc111 chemicals, 3 rings
3-(Benzhydryloxy)-8-azabicyclo[3.2.1]octane11 chemicals, 4 rings
O=C(Cc1csc(NC(=O)Nc2ccccc2)n1)Nc1ccccc111 chemicals, 3 rings
2-((1-Oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-phenylacetamide11 chemicals, 3 rings
Thiochroman-4-one11 chemicals, 2 rings![Scaffold C(c1ccc[nH]1)=c1ccc(=C2C=c3ccccc3=N2)[nH]1](/scaffold/DCOGLYOEMFOAMH-UHFFFAOYSA-N/structure.svg)
C(c1ccc[nH]1)=c1ccc(=C2C=c3ccccc3=N2)[nH]111 chemicals, 4 rings
2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide11 chemicals, 4 rings
C(=Cc1ccccc1)CN1CCN(C(c2ccccc2)c2ccccc2)CC111 chemicals, 4 rings
O=C(NCC1CCCO1)Nc1ccccc111 chemicals, 2 rings![Scaffold O=c1[nH]cnc2sc(-c3ccccc3)cc12](/scaffold/DOGYRNXYBVJXFA-UHFFFAOYSA-N/structure.svg)
6-Phenyl-3H,4H-thieno[2,3-d]pyrimidin-4-one11 chemicals, 3 rings
O=C(COc1ccccc1)NCCC1=CCCCC111 chemicals, 2 rings![Scaffold O=C(c1ccccc1)c1cn[nH]c1-c1ccccc1](/scaffold/DPVDUFOFGIXNIE-UHFFFAOYSA-N/structure.svg)
O=C(c1ccccc1)c1cn[nH]c1-c1ccccc111 chemicals, 3 rings
N-Benzyl-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide11 chemicals, 3 rings
2,2':6',2''-Terpyridine11 chemicals, 3 rings![Scaffold O=C(Cc1nc2ccccc2[nH]1)c1ccccc1](/scaffold/DROIEDFLBXSKRS-UHFFFAOYSA-N/structure.svg)
2-(1H-Benzoimidazol-2-yl)-1-phenyl-ethanone11 chemicals, 3 rings
N-(Furan-2-ylmethyl)quinazolin-4-amine11 chemicals, 3 rings
O=C(Cn1ncc2ccccc2c1=O)Nc1ccccc111 chemicals, 3 rings
3-Phenoxythiophene11 chemicals, 2 rings
2-(Pyridin-3-yl)pyrimidine11 chemicals, 2 rings
N-Phenyl-2-(phenylmethoxy)benzenemethanamine11 chemicals, 3 rings
8-Oxa-1-azaspiro[4.5]decane11 chemicals, 2 rings![Scaffold [BH2-]1n2cccc2C=C2C=CC=[N+]12](/scaffold/FDIIAZRSDGSTLB-UHFFFAOYSA-N/structure.svg)
[BH2-]1n2cccc2C=C2C=CC=[N+]1211 chemicals, 3 rings
6-Phenylpyrazolo[1,5-a]pyrimidine11 chemicals, 3 rings![Scaffold c1ccc2[nH]c(C3CCCN3)nc2c1](/scaffold/FHGVBMUGKDNVNB-UHFFFAOYSA-N/structure.svg)
2-Pyrrolidin-2-yl-1H-benzoimidazole11 chemicals, 3 rings
C1CC2CCC2N111 chemicals, 2 rings![Scaffold O=C(CSc1ncn[nH]1)NC1CCCCC1](/scaffold/FKSCOZSUODMJCP-UHFFFAOYSA-N/structure.svg)
N-Cyclohexyl-2-(1H-1,2,4-triazol-5-ylsulfanyl)acetamide11 chemicals, 2 rings
O=C1CC(C(=O)Nc2ccccc2)SC(=Nc2ccccc2)N111 chemicals, 3 rings
2-Piperidinobenzothiazole11 chemicals, 3 rings
O=C(OC1CC2C1C=CC1CCCC12)c1ccccc111 chemicals, 4 rings![Scaffold c1ccc2[nH]c(B3OCCO3)cc2c1](/scaffold/FMNRJPMZUWZFSH-UHFFFAOYSA-N/structure.svg)
c1ccc2[nH]c(B3OCCO3)cc2c111 chemicals, 3 rings
(2-(Benzylthio)-4,5-dihydro-1H-imidazol-1-yl)(furan-2-yl)methanone11 chemicals, 3 rings
O=c1c(-c2ccc3c(c2)OCCO3)coc2ccccc1211 chemicals, 4 rings
C1CC(C2CC2)CCO111 chemicals, 2 rings
2,1-Benzisoxazole11 chemicals, 2 rings
2-Isonicotinoyl-N-phenylhydrazinecarbothioamide11 chemicals, 2 rings![Scaffold O=C(c1ccco1)N1CCN(Cc2nc3[nH]c(=O)[nH]c(=O)c3[nH]2)CC1](/scaffold/GDUOYYGSSDLYLH-UHFFFAOYSA-N/structure.svg)
O=C(c1ccco1)N1CCN(Cc2nc3[nH]c(=O)[nH]c(=O)c3[nH]2)CC111 chemicals, 4 rings
Benzylidene-pyridin-2-YL-amine11 chemicals, 2 rings
6-Phenylimidazo(2,1-b)(1,3,4)thiadiazole11 chemicals, 3 rings![Scaffold O=C(NNC(=S)Nc1ccccc1)c1cc[nH]n1](/scaffold/GFTUZBZNWRQYBL-UHFFFAOYSA-N/structure.svg)
O=C(NNC(=S)Nc1ccccc1)c1cc[nH]n111 chemicals, 2 rings
O=C(COc1ccccc1)NC1C(=O)N2CCSC1211 chemicals, 3 rings
O=C(NN=Cc1ccccc1OCc1ccccc1)c1ccccc111 chemicals, 3 rings